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Ahmadloo, Niloofar, Kameli, Parisa, Ansari, Mansour, Mosalaei, Ahmad, Omidvari, Shapour, Nasrollahi, Hamid, Hamedi, Seyed Hassan, Mohammadianpanah, Mohammad. (1401). Effect of Zinc Sulfate on Overall Survival and Progression-Free Survival in Patients with Glioblastoma Multiforme, a Phase II Study. سامانه مدیریت نشریات علمی, 14(1), 113-118. doi: 10.30476/mejc.2021.90568.1583
Niloofar Ahmadloo; Parisa Kameli; Mansour Ansari; Ahmad Mosalaei; Shapour Omidvari; Hamid Nasrollahi; Seyed Hassan Hamedi; Mohammad Mohammadianpanah. "Effect of Zinc Sulfate on Overall Survival and Progression-Free Survival in Patients with Glioblastoma Multiforme, a Phase II Study". سامانه مدیریت نشریات علمی, 14, 1, 1401, 113-118. doi: 10.30476/mejc.2021.90568.1583
Ahmadloo, Niloofar, Kameli, Parisa, Ansari, Mansour, Mosalaei, Ahmad, Omidvari, Shapour, Nasrollahi, Hamid, Hamedi, Seyed Hassan, Mohammadianpanah, Mohammad. (1401). 'Effect of Zinc Sulfate on Overall Survival and Progression-Free Survival in Patients with Glioblastoma Multiforme, a Phase II Study', سامانه مدیریت نشریات علمی, 14(1), pp. 113-118. doi: 10.30476/mejc.2021.90568.1583
Ahmadloo, Niloofar, Kameli, Parisa, Ansari, Mansour, Mosalaei, Ahmad, Omidvari, Shapour, Nasrollahi, Hamid, Hamedi, Seyed Hassan, Mohammadianpanah, Mohammad. Effect of Zinc Sulfate on Overall Survival and Progression-Free Survival in Patients with Glioblastoma Multiforme, a Phase II Study. سامانه مدیریت نشریات علمی, 1401; 14(1): 113-118. doi: 10.30476/mejc.2021.90568.1583

Effect of Zinc Sulfate on Overall Survival and Progression-Free Survival in Patients with Glioblastoma Multiforme, a Phase II Study

Middle East Journal of Cancer
مقاله 11، دوره 14، شماره 1 - شماره پیاپی 53، فروردین 2023، صفحه 113-118    اصل مقاله (247.41 K)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/mejc.2021.90568.1583
نویسندگان
Niloofar Ahmadloo1؛ Parisa Kameli1؛ Mansour Ansari2؛ Ahmad Mosalaei1؛ Shapour Omidvari2؛ Hamid Nasrollahi* 1؛ Seyed Hassan Hamedi1؛ Mohammad Mohammadianpanah3
1Radiation Oncology Department, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
2Breast Diseases Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
3Colorectal Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Background: Glioblastoma is the most prevalent and aggressive adult glial tumor. Patients who receive standard treatment have a mean survival of 12-14 months. Zinc is a micronutrient that has shown to have anticancerous effects. In the in vitro studies zinc had antineoplastic effects on gliobalstoma cells.
Method: This is a phase II randomized trial in which 60 patients in two groups were evaluated. The zinc group (29 patients) received zinc sulfate supplement 50 mg orally twice a day and the control group (31 patients) who were selected from historical case sreceived no supplements.
Results: Mean overall survival in the case and control groups were 9.93 (± 3.29) and 9.0 (± 3.56) months. In the case and control groups, the mean disease-free survival were 9.62 (SD ± 3.37) and 8.26 (SD ± 3.47) months. These differences were not statistically significant. Although overall survival and recurrence-free survival in patients in the case group was higher than the control group, there was no statistically significant difference (P = 0.485).
Conclusion: Zinc consumption was associated with better survival, but these differences were not statistically significant, necessitating further studies.
کلیدواژه‌ها
Glioblastoma multiforme؛ Chemotherapy؛ Radiotherapy؛ Zinc sulfate
مراجع
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