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Askari, Mehdi, Khezri, Mehrdad, Zoghi, Ghazal. (1401). Introducing a Novel Combination Therapy with Macrolides for the Treatment of Chronic Rhinosinusitis: A Randomized Controlled Trial. سامانه مدیریت نشریات علمی, 47(6), 533-540. doi: 10.30476/ijms.2021.91813.2303
Mehdi Askari; Mehrdad Khezri; Ghazal Zoghi. "Introducing a Novel Combination Therapy with Macrolides for the Treatment of Chronic Rhinosinusitis: A Randomized Controlled Trial". سامانه مدیریت نشریات علمی, 47, 6, 1401, 533-540. doi: 10.30476/ijms.2021.91813.2303
Askari, Mehdi, Khezri, Mehrdad, Zoghi, Ghazal. (1401). 'Introducing a Novel Combination Therapy with Macrolides for the Treatment of Chronic Rhinosinusitis: A Randomized Controlled Trial', سامانه مدیریت نشریات علمی, 47(6), pp. 533-540. doi: 10.30476/ijms.2021.91813.2303
Askari, Mehdi, Khezri, Mehrdad, Zoghi, Ghazal. Introducing a Novel Combination Therapy with Macrolides for the Treatment of Chronic Rhinosinusitis: A Randomized Controlled Trial. سامانه مدیریت نشریات علمی, 1401; 47(6): 533-540. doi: 10.30476/ijms.2021.91813.2303

Introducing a Novel Combination Therapy with Macrolides for the Treatment of Chronic Rhinosinusitis: A Randomized Controlled Trial

Iranian Journal of Medical Sciences
مقاله 4، دوره 47، شماره 6، بهمن 2022، صفحه 533-540    اصل مقاله (342.89 K)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/ijms.2021.91813.2303
نویسندگان
Mehdi Askari* 1؛ Mehrdad Khezri2؛ Ghazal Zoghi3
1Department of Otorhinolaryngology, School of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
2Department of Radiology, School of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
3Endocrinology and Metabolism Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
چکیده
Background: Macrolides have shown beneficial effects in the treatment of chronic rhinosinusitis (CRS). This study aimed to compare the effect of azithromycin and clarithromycin in combination with conventional therapies for the treatment of CRS.
Methods: This single-blind randomized controlled trial was conducted during 2018-2019 at the Otorhinolaryngology Clinic of Shahid Mohammadi Hospital, Bandar Abbas, Iran. Out of 102 selected patients, 90 were included in the analysis. Patients were selected through convenience sampling and randomly assigned to two equal groups. In addition to conventional therapies (nasal irrigation, betamethasone injection, oxymetazoline and fluticasone spray, guaifenesin syrup, and steam inhalation), the patients in the clarithromycin group received clarithromycin 500 mg tablets twice daily for four weeks. The other group received azithromycin 500 mg tablets daily for four weeks. Patients’ symptoms were evaluated pre- and post-intervention, and the Lund-Mackay (LM) scoring system was used for the staging of CRS based on computed tomography scan findings. Data were analyzed using SPSS software, and P<0.05 was considered statistically significant.
Results: Patients in both groups were comparable in terms of age and sex. Complete resolution of symptoms was significantly higher in the azithromycin group than the clarithromycin group (71.1% vs. 24.4%, P<0.001). Baseline LM scores did not differ significantly between the groups (P=0.120). However, post-intervention, LM scores reduced considerably in both groups, but the change was significantly higher in the azithromycin group (P<0.001). 
Conclusion: In combination with conventional therapies for CRS in adults, a four-week course of treatment with azithromycin is more effective than clarithromycin.
Trial Registration Number: IRCT20201209049661N1.
کلیدواژه‌ها
Azithromycin؛ Chronic sinusitis؛ Clarithromycin؛ Drug therapy؛ Combination؛ Macrolides
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