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Evaluation of nootropic activity of standardized Epipremnum aureum extract against scopolamine-induced amnesia in experimental animals | ||
| Journal of Advanced Medical Sciences and Applied Technologies | ||
| دوره 6، شماره 1، اسفند 2021، صفحه 64-71 اصل مقاله (523.79 K) | ||
| نوع مقاله: Original Articles | ||
| شناسه دیجیتال (DOI): 10.30476/jamsat.2021.48386 | ||
| نویسندگان | ||
| Sreemoy Kanti das1؛ G. S Chakraborthy2؛ Tulika Chakrabarti3؛ Prasun Chakrabarti4؛ Mohammad Javad Gholamzadeh* 5؛ Mohammad Nami6، 7، 8، 9 | ||
| 1Lecturer, Faculty of Pharmacy, Lincoln University College, Selangor, Malaysia | ||
| 2Principal and Professor, Parul Institute of Pharmacy & Research, Gujarat, India | ||
| 3Department of Chemistry, Sir Padampat Singhania University, Udaipur 313601, Rajasthan, India | ||
| 4Provost and Institute Endowed Distinguished Senior Chair Professor, Techno India NJR Institute of Technology, Udaipur 313003, Rajasthan, India | ||
| 5Students’ Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| 6Department of Neuroscience, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| 7Neuroscience laboratory-NSL (Brain, Cognition, and Behavior), School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| 8Neuroscience Center, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP), City of Knowledge, Panama | ||
| 9Dana Brain Health Institute, Iranian Neuroscience Society, Fars Chapter, Shiraz, Iran | ||
| چکیده | ||
| Introduction: Various plant species of genus Epipremnum have already been reported to have different types of pharmacological activities. However, another plant of the same genus Epipremnum aureum has not been scientifically exposed to a significant extent to date. Although it contains many bioactives, it has only been studied for antidepressant activity. The present study aims to evaluate the nootropic potential of standardized extract of Epipremnum aureum against scopolamine-induced amnesia in experimental animals. Method: The nootropic potential of Epipremnum aureum was evaluated using an elevated plus maze and Morris water maze apparatus. A dose of 400mg/kg and 600mg/kg was used to access the nootropic activity. Scopolamine (0.4 mg/kg) was used to induce amnesia in mice. Additionally, the anti-acetylcholinesterase activity of the extract was evaluated by measuring the level of acetylcholinesterase in the mice brain. Result: Epipremnum aureum was found to increase memory and reverse the amnesic action of scopolamine in a dose-dependent manner. In elevated plus maze and Morris water maze, Epipremnum aureum decreased the transfer latency as compared to the control group. Further biochemical investigation revealed an increased level of acetylcholine and decreased level of TBARS resulting in reversing the effect of scopolamine in amnesic mice. Conclusion: Epipremnum aureum showed positive results in reversing the amnesia action of scopolamine which may be the probable mechanism for its memory retention activity. Based on the experimental outcome, the present study provides a piece of scientific evidence for the nootropic potential of Epipremnum aureum in experimental animals. | ||
| کلیدواژه‌ها | ||
| Acetyl-cholinesterase؛ Morris water maze؛ Elevated plus maze؛ thin-layer chromatography | ||
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