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Sadeghian, Sara, Gholami, Ahmad, Khabnadideh, Soghra, Razmi, Razieh, Sadeghian, Issa, Ghasemi, Younes, Rezaei, Zahra. (1401). Evaluation of Antibacterial and Anticandidal Activities of Some Imidazole, Benzimidazole and Benztriazole Derivatives. سامانه مدیریت نشریات علمی, 8(2), 75-84. doi: 10.30476/tips.2022.93637.1126
Sara Sadeghian; Ahmad Gholami; Soghra Khabnadideh; Razieh Razmi; Issa Sadeghian; Younes Ghasemi; Zahra Rezaei. "Evaluation of Antibacterial and Anticandidal Activities of Some Imidazole, Benzimidazole and Benztriazole Derivatives". سامانه مدیریت نشریات علمی, 8, 2, 1401, 75-84. doi: 10.30476/tips.2022.93637.1126
Sadeghian, Sara, Gholami, Ahmad, Khabnadideh, Soghra, Razmi, Razieh, Sadeghian, Issa, Ghasemi, Younes, Rezaei, Zahra. (1401). 'Evaluation of Antibacterial and Anticandidal Activities of Some Imidazole, Benzimidazole and Benztriazole Derivatives', سامانه مدیریت نشریات علمی, 8(2), pp. 75-84. doi: 10.30476/tips.2022.93637.1126
Sadeghian, Sara, Gholami, Ahmad, Khabnadideh, Soghra, Razmi, Razieh, Sadeghian, Issa, Ghasemi, Younes, Rezaei, Zahra. Evaluation of Antibacterial and Anticandidal Activities of Some Imidazole, Benzimidazole and Benztriazole Derivatives. سامانه مدیریت نشریات علمی, 1401; 8(2): 75-84. doi: 10.30476/tips.2022.93637.1126

Evaluation of Antibacterial and Anticandidal Activities of Some Imidazole, Benzimidazole and Benztriazole Derivatives

Trends in Pharmaceutical Sciences
مقاله 4، دوره 8، شماره 2، شهریور 2022، صفحه 75-84    اصل مقاله (623.28 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.30476/tips.2022.93637.1126
نویسندگان
Sara Sadeghian1؛ Ahmad Gholami2، 3؛ Soghra Khabnadideh4، 3؛ Razieh Razmi1؛ Issa Sadeghian3؛ Younes Ghasemi* 3، 5؛ Zahra Rezaei* 1، 3
1Department of Medicinal Chemistry, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
2Biotechnology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
3Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
4Department of Medicinal Chemistry, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
5Department of Pharmaceutical Biotechnology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
In recent years, resistance to conventional antimicrobial drugs has become a serious concern in the clinic. Hence, the discovery of novel and effective antimicrobial agents with improved properties is of great value. In this study, the antibacterial and anticandidal activities of some imidazole, benzimidazole and benztriazole derivatives (C1-C8) against several species of Gram-positive and Gram-negative bacteria, including Staphylococcus aureus, Streptococcus pyogenes, Escherichia coli and Salmonella typhi as well as one species of fungi including Candida albicans, were evaluated using Clinical & Laboratory Standards Institute (CLSI) method. Antimicrobial evaluation revealed that among the tested compounds, imidazole derivative (C5) indicated the highest activity against bacterial strains and Candida albicans. It was found that compound C5 is more potent than ampicillin against S. aureus strain (MIC =2-16 µg/mL) and possessed excellent anticandidal activity (MIC =1 µg/mL) which was comparable to Amphotericin B as the positive control. In addition, cytotoxic activity of the tested compounds was investigated using MTT assay. The results of MTT assay demonstrated that the toxicity of the tested compounds was less than 35%.  
Please cite this article as: Sara Sadeghian, Ahmad Gholami, Soghra Khabnadideh, Razieh Razmi, Issa Sadeghain, Younes Ghasemi & Zahra Rezaei. Evaluation of Antibacterial and Anticandidal Activities of Some Imidazole, Benzimidazole and Benztriazole Derivatives. Trends in Pharmaceutical Sciences. 2022;8(2):75-84  .doi: 10.30476/TIPS.2022.93637.1126
کلیدواژه‌ها
Azoles؛ Antimicrobial effect؛ Antifungal activity؛ MTT
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