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Firouzabadi, Negar, Javdani, Kimia, Dehshahri, Ali. (1401). Interleukin-33 and Soluble ST2 as Potential Biomarkers of Cancer in Opium Users: A Nested Case-Control Study. سامانه مدیریت نشریات علمی, 47(6), 541-548. doi: 10.30476/ijms.2021.92335.2360
Negar Firouzabadi; Kimia Javdani; Ali Dehshahri. "Interleukin-33 and Soluble ST2 as Potential Biomarkers of Cancer in Opium Users: A Nested Case-Control Study". سامانه مدیریت نشریات علمی, 47, 6, 1401, 541-548. doi: 10.30476/ijms.2021.92335.2360
Firouzabadi, Negar, Javdani, Kimia, Dehshahri, Ali. (1401). 'Interleukin-33 and Soluble ST2 as Potential Biomarkers of Cancer in Opium Users: A Nested Case-Control Study', سامانه مدیریت نشریات علمی, 47(6), pp. 541-548. doi: 10.30476/ijms.2021.92335.2360
Firouzabadi, Negar, Javdani, Kimia, Dehshahri, Ali. Interleukin-33 and Soluble ST2 as Potential Biomarkers of Cancer in Opium Users: A Nested Case-Control Study. سامانه مدیریت نشریات علمی, 1401; 47(6): 541-548. doi: 10.30476/ijms.2021.92335.2360

Interleukin-33 and Soluble ST2 as Potential Biomarkers of Cancer in Opium Users: A Nested Case-Control Study

Iranian Journal of Medical Sciences
مقاله 5، دوره 47، شماره 6، بهمن 2022، صفحه 541-548    اصل مقاله (268.61 K)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/ijms.2021.92335.2360
نویسندگان
Negar Firouzabadi* 1، 2، 3؛ Kimia Javdani4؛ Ali Dehshahri5
1Department of Pharmacology and Toxicology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
2Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
3Non-Communicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran
4Department of Pharmacology and Toxicology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
5Department of Pharmaceutical Biotechnology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Background: Opium abuse is one of the social hazards in the Middle Eastern countries. Opium consumption attributes to various malignancies. However, the exact molecular mechanism of this correlation still remains unclear. Cancer and inflammation are closely correlated. Interleukin-33 (IL-33) and its receptors, transmembrane ST2 (ST2L) and soluble ST2 (sST2), have been significantly associated with tumorigenicity. The present study aimed to investigate whether IL-33 and sST2 levels serve as cancer biomarkers in opium users.
Methods: Serum samples were collected from 100 opium users and 100 healthy non-opium users in a nested case-control design. The subjects with over five years of history of opium abuse were enrolled. To assess the incidence of malignancies, the opium users were followed up from 2014 to 2019. Serum levels of IL-33 and sST2 were measured using an ELISA kit. For comparison of IL-33 and sST2 levels between the groups, two-tailed Student’s t test and Mann–Whitney U test were utilized, accordingly. Logistic regression analysis was performed to evaluate the influence of confounders on the incidence of cancer.
Results: During the five-year follow-up, eight opium users were diagnosed with cancer. Cancer was developed by 9.3 folds in the individuals abusing opium compared to that in the non-opium users (P=0.040, OR=9.3; 95%CI [1.1-79.4]). Serum levels of IL-33 were found to be significantly higher in the opium users than those in the healthy control group (P=0.001). The sST2 levels were significantly lower in the opium users (P=0.001). The opium users with cancer exhibited significantly higher levels of IL-33 and lower levels of sST2 than the cancer-free ones (P=0.001). 
Conclusion: Decline in sST2 levels and rise in the level of IL-33 are valuable biomarkers in predicting cancers. Regarding the significant alterations in the levels of these biomarkers in the opium users, as well as those in the opium users diagnosed with cancer, IL-33 and sST2 may serve as potential biomarkers in the early prediction of cancer.
کلیدواژه‌ها
Opium؛ Opium dependence؛ Interleukin-33؛ Neoplasms؛ Inflammation؛ Biomarkers؛ Tumor
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