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Noroozi, Mehran, Khalkhali, Hamid Reza, Bahadori, Robabeh, Omidi, Tahereh, Ghazizadeh, Farid, Hejazi, Sasan, Mahdi-Akhgar, Masoumeh, Valizadeh, Rohollah. (1401). The Survival of Childhood Acute Lymphoblastic Leukemia and its Related Factors Using Competing Risks Model: A Retrospective Study from 2011 to 2019 in Northwestern Iran. سامانه مدیریت نشریات علمی, 13(3), 531-542. doi: 10.30476/mejc.2022.88069.1455
Mehran Noroozi; Hamid Reza Khalkhali; Robabeh Bahadori; Tahereh Omidi; Farid Ghazizadeh; Sasan Hejazi; Masoumeh Mahdi-Akhgar; Rohollah Valizadeh. "The Survival of Childhood Acute Lymphoblastic Leukemia and its Related Factors Using Competing Risks Model: A Retrospective Study from 2011 to 2019 in Northwestern Iran". سامانه مدیریت نشریات علمی, 13, 3, 1401, 531-542. doi: 10.30476/mejc.2022.88069.1455
Noroozi, Mehran, Khalkhali, Hamid Reza, Bahadori, Robabeh, Omidi, Tahereh, Ghazizadeh, Farid, Hejazi, Sasan, Mahdi-Akhgar, Masoumeh, Valizadeh, Rohollah. (1401). 'The Survival of Childhood Acute Lymphoblastic Leukemia and its Related Factors Using Competing Risks Model: A Retrospective Study from 2011 to 2019 in Northwestern Iran', سامانه مدیریت نشریات علمی, 13(3), pp. 531-542. doi: 10.30476/mejc.2022.88069.1455
Noroozi, Mehran, Khalkhali, Hamid Reza, Bahadori, Robabeh, Omidi, Tahereh, Ghazizadeh, Farid, Hejazi, Sasan, Mahdi-Akhgar, Masoumeh, Valizadeh, Rohollah. The Survival of Childhood Acute Lymphoblastic Leukemia and its Related Factors Using Competing Risks Model: A Retrospective Study from 2011 to 2019 in Northwestern Iran. سامانه مدیریت نشریات علمی, 1401; 13(3): 531-542. doi: 10.30476/mejc.2022.88069.1455

The Survival of Childhood Acute Lymphoblastic Leukemia and its Related Factors Using Competing Risks Model: A Retrospective Study from 2011 to 2019 in Northwestern Iran

Middle East Journal of Cancer
مقاله 18، دوره 13، شماره 3 - شماره پیاپی 51، مهر 2022، صفحه 531-542    اصل مقاله (938.96 K)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/mejc.2022.88069.1455
نویسندگان
Mehran Noroozi1؛ Hamid Reza Khalkhali2؛ Robabeh Bahadori3؛ Tahereh Omidi4؛ Farid Ghazizadeh5؛ Sasan Hejazi1؛ Masoumeh Mahdi-Akhgar* 5؛ Rohollah Valizadeh6، 7
1Department of Pediatric Hematology, Motahari Hospital, Urmia University of Medical Sciences, Urmia, Iran
2Department of Biostatistics, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran
3Department of Pediatric, Urmia University of Medical Sciences, Urmia, Iran
4Department of Biostatistics, Hamadan University of Medical Sciences, Hamadan, Iran
5Solid Tumor Research center, Urmia University of Medical Sciences, Urmia, Iran
6Department of Epidemiology, Student Research Committee, School of Public Health, Iran University of Medical Science, Tehran, Iran
7Minimally Invasive Surgery Research Center, Iran University of Medical Sciences, Tehran, Iran
چکیده
Background: We aimed to evaluate the survival rate and define the prognostic factors in children with acute lymphoblastic leukemia (ALL).
Method: In this retrospective study, the data were extracted from the medical records of 176 children with ALL who referred to Motahari Hospital in Urmia from 2011 to 2019. Endpoints of overall survival study were event-free survival, disease-free survival, and recurrent mortality. Overall survival and disease-free survival were the time from diagnosis to death of any cause or recurrence. Event-free survival time was calculated as the distance from the date of diagnosis to the date of the last prevention with the first event. Non-recurrent mortality included all non-recurrent deaths. Data analysis was performed using a cause-specific hazard model.
Results: The mean age of the patients was 5.61 ± 3.56 years and the median of diagnosis of ALL to death was 3.47 ± 2.61 years. The 1-year, 3- year and 5-year probability of survival were 83.1%, 75.10%, and 68%, respectively. Sex, hemoglobin level, and hepatosplenomegaly were significant in univariate and multivariate analysis (P < 0.05).
Conclusion: The competing risks model was applied to identify the risk factors for all causes of death. The factors affecting the survival rate of patients in the model can be employed in making clinical decisions and proposing therapeutic protocols. Furthermore, it reduces the duration of response to therapy, thereby decreasing the rate of mortality in children.
کلیدواژه‌ها
Leukemia؛ Lymphoid؛ Cause-specific hazards؛ Neoplasms؛ Childhood؛ Competing risk
اصل مقاله

How to cite this article:

Noroozi M, Khalkhali HR, Bahadori R, Omidi T, Ghazizadeh F, Hejazi S, et al. The survival of childhood acute lymphoblastic leukemia and its related factors using competing risks model: A retrospective study from 2011 to 2019 in northwestern Iran. Middle East J Cancer. 2022;13(3):531-42. doi: 10.30476/mejc.2022.88069.1455.

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