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Adekunle, Yemi, Samuel, Babatunde, Emmanuel, Toluwanimi, Adeniji, Johnson, Ogbole, Omonike. (1400). Cytotoxicity Analysis of Nineteen Medicinal Plants Extracts on Breast Adenocarcinoma (MCF-7) and Rhabdomyosarcoma (RD) Cancer Cell Lines. سامانه مدیریت نشریات علمی, 8(1), 57-64. doi: 10.30476/tips.2022.94313.1136
Yemi Adekunle; Babatunde Samuel; Toluwanimi Emmanuel; Johnson Adeniji; Omonike Ogbole. "Cytotoxicity Analysis of Nineteen Medicinal Plants Extracts on Breast Adenocarcinoma (MCF-7) and Rhabdomyosarcoma (RD) Cancer Cell Lines". سامانه مدیریت نشریات علمی, 8, 1, 1400, 57-64. doi: 10.30476/tips.2022.94313.1136
Adekunle, Yemi, Samuel, Babatunde, Emmanuel, Toluwanimi, Adeniji, Johnson, Ogbole, Omonike. (1400). 'Cytotoxicity Analysis of Nineteen Medicinal Plants Extracts on Breast Adenocarcinoma (MCF-7) and Rhabdomyosarcoma (RD) Cancer Cell Lines', سامانه مدیریت نشریات علمی, 8(1), pp. 57-64. doi: 10.30476/tips.2022.94313.1136
Adekunle, Yemi, Samuel, Babatunde, Emmanuel, Toluwanimi, Adeniji, Johnson, Ogbole, Omonike. Cytotoxicity Analysis of Nineteen Medicinal Plants Extracts on Breast Adenocarcinoma (MCF-7) and Rhabdomyosarcoma (RD) Cancer Cell Lines. سامانه مدیریت نشریات علمی, 1400; 8(1): 57-64. doi: 10.30476/tips.2022.94313.1136

Cytotoxicity Analysis of Nineteen Medicinal Plants Extracts on Breast Adenocarcinoma (MCF-7) and Rhabdomyosarcoma (RD) Cancer Cell Lines

Trends in Pharmaceutical Sciences
دوره 8، شماره 1، خرداد 2022، صفحه 57-64    اصل مقاله (429.37 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.30476/tips.2022.94313.1136
نویسندگان
Yemi Adekunle1؛ Babatunde Samuel* 1؛ Toluwanimi Emmanuel2؛ Johnson Adeniji3؛ Omonike Ogbole2
1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ibadan University, Nigeria.
2Department of Pharmacognosy, Faculty of Pharmacy, Ibadan University, Nigeria.
3WHO Polio Laboratory, Department of Virology, College of Medicine, badan University, Nigeria.
چکیده
The burden of cancer is alarmingly great on humans. However, the relevance of plants in combating cancer cannot be undermine. We joined the global search for anticancer agents from plants by screening nineteen (19) medicinal plant extracts on human breast carcinoma (MCF-7) and rhabdomyosarcoma (RD) cell lines using the 3- [4, 5-dimethylthiazol–2-yl]-2,5-diphenyltetrazolium bromide (MTT) assay. Vincristine was used as the positive reference. Results were presented as mean IC50±standard error of the mean using GraphPad Prism (6.0). One-way ANOVA was used to establish the level of statistical significance. The results showed that twelve of the extracts were moderately cytotoxic on MCF-7 while seven were moderately active on RD (IC50, 30-100 µg/mL). Two of the extracts, Afzelia africana stem and Anogeissus leiocarpus root, showed significant activity on MCF-7 while seven had significant activity on RD (IC50  
Please cite this article as: Yemi A. Adekunle, Babatunde B. Samuel*, Toluwanimi E Akinleye, Adekunle J. Adeniji, Omonike O. Ogbole. Cytotoxicity Analysis of Nineteen Medicinal Plants Extracts on Breast Adenocarcinoma (MCF-7) and Rhabdomyosarcoma (RD) Cancer Cell Lines. Trends in Pharmaceutical Sciences. 2022;8(1):57-64 .doi: 10.30476/TIPS.2022.94313.1136
کلیدواژه‌ها
Cytotoxicity؛ Medicinal Plants؛ Breast Cancer؛ Rhabdomyosarcoma
مراجع
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