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Li, Wei, Li, Lin, He, Lin, Du, Yun, Fu, Hai-Dong, Peng, Zhao-Yang, Xiang, Wen-Qing, Mao, Jian-Hua. (1400). Cytokine Gene Polymorphisms in Chinese Children with Idiopathic Nephrotic Syndrome. سامانه مدیریت نشریات علمی, 19(1), 102-109. doi: 10.22034/iji.2022.92367.2146
Wei Li; Lin Li; Lin He; Yun Du; Hai-Dong Fu; Zhao-Yang Peng; Wen-Qing Xiang; Jian-Hua Mao. "Cytokine Gene Polymorphisms in Chinese Children with Idiopathic Nephrotic Syndrome". سامانه مدیریت نشریات علمی, 19, 1, 1400, 102-109. doi: 10.22034/iji.2022.92367.2146
Li, Wei, Li, Lin, He, Lin, Du, Yun, Fu, Hai-Dong, Peng, Zhao-Yang, Xiang, Wen-Qing, Mao, Jian-Hua. (1400). 'Cytokine Gene Polymorphisms in Chinese Children with Idiopathic Nephrotic Syndrome', سامانه مدیریت نشریات علمی, 19(1), pp. 102-109. doi: 10.22034/iji.2022.92367.2146
Li, Wei, Li, Lin, He, Lin, Du, Yun, Fu, Hai-Dong, Peng, Zhao-Yang, Xiang, Wen-Qing, Mao, Jian-Hua. Cytokine Gene Polymorphisms in Chinese Children with Idiopathic Nephrotic Syndrome. سامانه مدیریت نشریات علمی, 1400; 19(1): 102-109. doi: 10.22034/iji.2022.92367.2146

Cytokine Gene Polymorphisms in Chinese Children with Idiopathic Nephrotic Syndrome

Iranian Journal of Immunology
دوره 19، شماره 1، خرداد 2022، صفحه 102-109    اصل مقاله (2.19 M)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22034/iji.2022.92367.2146
نویسندگان
Wei Li1؛ Lin Li1؛ Lin He1؛ Yun Du2؛ Hai-Dong Fu3؛ Zhao-Yang Peng1؛ Wen-Qing Xiang1؛ Jian-Hua Mao* 3
1Department of Clinical Laboratory, The Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health. Hangzhou 310052, PR China.
2Department of Respiratory Medicine, Jiangxi Provincial Children’s Hospital, PR China.
3Department of Nephrology, The Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou 310052, PR China.
چکیده
Background: Cytokines play a role in the progression of idiopathic-nephrotic syndrome (INS). Objectives: To investigate the association of different cytokine genes polymorphisms with INS incidence and response to steroid therapy in Chinese children. Methods: 182 children with INS and 100 healthy controls were enrolled in this study. Blood genomic DNAs were used to analyze20 single nucleotide polymorphisms (SNPs) in 8 cytokine genes includingIL-21, IL-18, IL-6, IFN-γ, IL-4, IL-10, IL-17F, IL-17A d by multi-PCR with next-generation sequencing. Results: Among 182 children with INS, 89 (48.6%) were steroid-sensitive (SS), 73 (39.9%) were steroid-dependent (SD) and 21 (11.5%) were steroid-resistant (SR). In 20 SNPs, IL-4-rs2243283 exhibited a significantly different genotype distribution between INS and the healthy controls (CC is a risk genotype: 66.5% of INS VS 51% of the control; OR=1.91, p=0.012). Patients carrying AG genotype (rs2275913, IL-17A) had a significantly higher risk of steroid-dependent response (69.1% of SD VS 46.4% of SS; OR=2.58, p=0.014). Similarly, patients carrying A allele of IL-10-rs1800872 (39.0% of SD VS 26.7% of SS; OR=1.76, p=0.018) and C allele of IL-10-rs1800896 (12.3% of SD VS 3.9% of SS; OR=3.44, p=0.004) had a higher risk of steroid-dependent response. However, none of these 20 SNPs showed a significant difference between SS group and SR group. Conclusion: Among the 20 cytokine gene SNPs, IL-4-rs2243283 might increase the susceptibility to INS in Chinese children; rs2275913 of IL-17A, rs1180972, and rs1800896 of IL-10 show association with the steroid -response in Chinese INS children.
کلیدواژه‌ها
Cytokine؛ Gene؛ Idiopathic-nephrotic؛ Syndrome؛ Polymorphisms
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