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Clinical and Radiographic Evaluation of Applying Atorvastatin 1.2% Bio Adhesive with Plasma Rich in Growth Factor (PRGF) for Treatment of Mandibular Class II Furcation Defects: a Randomized Clinical Trial | ||
| Journal of Dentistry | ||
| مقاله 2، دوره 23، شماره 2 - شماره پیاپی 75، 2022، صفحه 86-94 اصل مقاله (455.98 K) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.30476/dentjods.2021.84581.1090 | ||
| نویسندگان | ||
| Niloofar Jenabian1؛ Sakine Mohammadpour* 2؛ Sina Haghanifar3؛ Sohrab Kazemi4؛ Mahmod Hajiahmadi5 | ||
| 1Oral Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran. | ||
| 2Dept. of Periodontics, North Khorasan University of Medical Sciences, Bojnurd, Iran. | ||
| 3Oral Health Research Center, Health Research Institute, Oral and Maxillofacial Radiology, Babol University of Medical Sciences, Babol, Iran. | ||
| 4Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran. | ||
| 5Dept. of Biostatistics and Epidemiology, Babol University of Medical Sciences, Babol, Iran. | ||
| چکیده | ||
| Statement of the Problem: Molar teeth with furcation involvement are one of the most common problems in patients with periodontal disease. Regeneration methods are of the most controversial treatment strategies for these lesions. Purpose: The purpose of this study was to determine the effect of plasma rich in growth factors (PRGF) with 1.2% Atorvastatin (ATV) in the treatment of furcation involvement of mandibular molars. Materials and Method: The present randomized clinical trial was conducted on 15 patients with moderate periodontitis and class II furcation involvements; 24 defects were located in four groups of six, including debridement, ATV1.2%, PRGF, PRGF with ATV1.2%. The parameters of vertical probing depth (VPD), vertical clinical attachment level (VCAL), gingival index (GI), horizontal probing depth (HPD) and gingival recession (GR) were measured at baseline (T0), immediately before surgery (T1), 3 (T2), and 6 (T3) months after surgery. Moreover, the bone conditions were evaluated by digital subtraction radiography before and six months after surgery. Data were analyzed using SPSS23 software. Results:No significant difference in radiographic parameters was observed among the groups (p= 0.08). There was no significant difference in the mean levels of VPD, VCAL and HPD among the groups at different times (p<0.05). Comparison of clinical parameters of VPD, VCAL and GI in the treatment groups compared to the baseline showed a significant improvement in each group (p< 0.05) but there was no significant difference among different groups (p< 0.05). Conclusion: The use ofPRGF with ATV 1.2% in grade II furcation involvement in mandi-bular molars was effective in the improvement of clinical and radiographic parameters six months after treatment, but this effect revealed no difference in comparison with the other groups. | ||
| کلیدواژه‌ها | ||
| Furcation defect؛ Growth factors؛ Atorvastatin | ||
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| مراجع | ||
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