پیوندهای مفید
آمار
| تعداد نشریات | 20 |
| تعداد شماره‌ها | 1,095 |
| تعداد مقالات | 10,041 |
| تعداد مشاهده مقاله | 28,021,276 |
| تعداد دریافت فایل اصل مقاله | 7,814,575 |
Clinical and Radiographic Evaluation of Applying Atorvastatin 1.2% Bio Adhesive with Plasma Rich in Growth Factor (PRGF) for Treatment of Mandibular Class II Furcation Defects: a Randomized Clinical Trial | ||
| Journal of Dentistry | ||
| مقاله 2، دوره 23، شماره 2 - شماره پیاپی 75، 2022، صفحه 86-94 اصل مقاله (455.98 K) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.30476/dentjods.2021.84581.1090 | ||
| نویسندگان | ||
| Niloofar Jenabian1؛ Sakine Mohammadpour* 2؛ Sina Haghanifar3؛ Sohrab Kazemi4؛ Mahmod Hajiahmadi5 | ||
| 1Oral Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran. | ||
| 2Dept. of Periodontics, North Khorasan University of Medical Sciences, Bojnurd, Iran. | ||
| 3Oral Health Research Center, Health Research Institute, Oral and Maxillofacial Radiology, Babol University of Medical Sciences, Babol, Iran. | ||
| 4Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran. | ||
| 5Dept. of Biostatistics and Epidemiology, Babol University of Medical Sciences, Babol, Iran. | ||
| چکیده | ||
| Statement of the Problem: Molar teeth with furcation involvement are one of the most common problems in patients with periodontal disease. Regeneration methods are of the most controversial treatment strategies for these lesions. Purpose: The purpose of this study was to determine the effect of plasma rich in growth factors (PRGF) with 1.2% Atorvastatin (ATV) in the treatment of furcation involvement of mandibular molars. Materials and Method: The present randomized clinical trial was conducted on 15 patients with moderate periodontitis and class II furcation involvements; 24 defects were located in four groups of six, including debridement, ATV1.2%, PRGF, PRGF with ATV1.2%. The parameters of vertical probing depth (VPD), vertical clinical attachment level (VCAL), gingival index (GI), horizontal probing depth (HPD) and gingival recession (GR) were measured at baseline (T0), immediately before surgery (T1), 3 (T2), and 6 (T3) months after surgery. Moreover, the bone conditions were evaluated by digital subtraction radiography before and six months after surgery. Data were analyzed using SPSS23 software. Results:No significant difference in radiographic parameters was observed among the groups (p= 0.08). There was no significant difference in the mean levels of VPD, VCAL and HPD among the groups at different times (p<0.05). Comparison of clinical parameters of VPD, VCAL and GI in the treatment groups compared to the baseline showed a significant improvement in each group (p< 0.05) but there was no significant difference among different groups (p< 0.05). Conclusion: The use ofPRGF with ATV 1.2% in grade II furcation involvement in mandi-bular molars was effective in the improvement of clinical and radiographic parameters six months after treatment, but this effect revealed no difference in comparison with the other groups. | ||
| کلیدواژه‌ها | ||
| Furcation defect؛ Growth factors؛ Atorvastatin | ||
|
سایر فایل های مرتبط با مقاله
|
||
| مراجع | ||
|
[1] Mehta DB, Deshpande NC, Dandekar SA. Comparative evaluation of platelet-rich fibrin membrane and collagen membrane along with demineralized freeze-dried bone allograft in Grade II furcation defects: A randomized controlled study. J Indian Soc Periodontol. 2018; 22: 322-327.
[2] Najim U, Slotte C, Norderyd O. Prevalence of furcation‐involved molars in a Swedish adult population. A radiographic epidemiological study. Clin Exp Dent Res. 2016; 2: 104-111.
[3] Newman MG, Takei H, Klokkevold PR, Carranza FA. Newman and Carranza's Clinical Periodontology E-Book. 13th ed. Elsevier Health Sciences: Philadelphia; 2019. p. 2134-2135.
[4] Troiano G, Laino L, Dioguardi M, Giannatempo G, Lo Muzio L, Lo Russo L. Mandibular Class II Furcation Defect Treatment: Effects of the Addition of Platelet Concentrates to Open Flap: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. J Periodontol. 2016; 87: 1030-1038.
[5] Inamdar MNK, Khan S, Ali SA, Ahmad E. Management of Class-II Furcation Complicated with Endodontic involvement using Two Different Regenerative Materials. J Int Oral Health. 2015; 7: 82-84.
[6] Mansouri SS, Ghasemi M, Darmian SS, Pourseyediyan T. Treatment of mandibular molar class II furcation defects in humans with bovine porous bone mineral in combination with plasma rich in growth factors. J Dent (Tehran). 2012; 9: 41-49.
[7] Jenabian N, Haghanifar S, Ehsani H, Zahedi E, Haghpanah M. Guided tissue regeneration and platelet rich growth factor for the treatment of Grade II furcation defects: a randomized double-blinded clinical trial- a pilot study. Dent Res J (Isfahan). 2017; 14: 363-369.
[8] Lafzi A, Shirmohammadi A, Faramarzi M, Jabali S, Shayan A. Clinical Comparison of Autogenous Bone Graft with and without Plasma Rich in Growth Factors in the Treatment of Grade II Furcation Involvement of Mandibular Molars. J Dent Res Dent Clin Dent Prospects. 2013; 7: 22-29.
[9] Camelo M, Nevins M. Treatment of Class II Furcations with Autogenous Bone Grafts and e-PTFE Membranes. Int J Periodontics Restorative Dent. 2000; 20: 233-243.
[10] Upadhyay P, Blaggana V, Tripathi P, Jindal M. Treatment of furcation involvement using autogenous tooth graft with 1‐year follow‐up: a case series. Clin Adv Periodontics. 2019; 9: 4-8.
[11] Khanna D, Malhotra S, Naidu DV. Treatment of grade II furcation involvement using resorbable guided tissue regeneration membrane: A six-month study. J Indian Soc Periodontol. 2012; 16: 404-410.
[12] Christgau M, Moder D, Wagner J, Glassl M, Hiller KA, Wenzel A, et al. Influence of autologous platelet concentrate on healing in intra-bony defects following guided tissue regeneration therapy: a randomized prospective clinical split-mouth study. J Clin Periodontol. 2006; 33: 908-921.
[13] Asimuddin S, Koduganti RR, Panthula VNR, Jammula SP, Dasari R, Gireddy H. Effect of autologous platelet rich fibrin in human mandibular molar grade II furcation defects- a randomized clinical trial. J Clin Diagn Res. 2017; 11: ZC73-ZC7.
[14] Tarallo F, Mancini L, Pitzurra L, Bizzarro S, Tepedino M, Marchetti E. Use of platelet-rich fibrin in the treatment of grade 2 furcation defects: systematic review and meta-analysis. J Clin Med. 2020; 9: 1-18.
[15] Bajaj P, Pradeep AR, Agarwal E, Rao NS, Naik SB, Priyanka N, et al. Comparative evaluation of autologous platelet-rich fibrin and platelet-rich plasma in the treatment of mandibular degree II furcation defects: a randomized controlled clinical trial. J Periodontal Res. 2013; 48: 573-581.
[16] Anitua E, Sanchez M, Orive G. Potential of endogenous regenerative technology for in situ regenerative medicine. Adv Drug Deliv Rev. 2010; 62: 741-752.
[17] Verma PK, Srivastava R, Gupta K, Chaturvedi T. Treatment strategy for guided tissue regeneration in various class II furcation defect: Case series. Dent Res J (Isfahan). 2013; 10: 689-694.
[18] Biswas S, Sambashivaiah S, Kulal R, Bilichodmath S, Kurtzman GM. Comparative Evaluation of Bioactive Glass (Putty) and Platelet Rich Fibrin in Treating Furcation Defects. J Oral Implantol. 2016; 42: 411-415.
[19] Panda S, Karanxha L, Goker F, Satpathy A, Taschieri S, Francetti L, et al. Autologous Platelet Concentrates in Treatment of Furcation Defects-A Systematic Review and Meta-Analysis. Int J Mol Sci. 2019; 20: 1347.
[20] Mehta D, Deshpande N, Dave D, Modi B, Bharwani A. Platelet rich fibrin: New treatment modality in Grade II furcation defects. J Oral Dis Marker. 2016; 1: 1-5.
[21] Garg S, Pradeep AR. 1.2% Rosuvastatin and 1.2% atorvastatin gel local drug delivery and redelivery in the treatment of class II furcation defects: a randomized controlled clinical trial. J Periodontol. 2017; 88: 259-265.
[22] Pradeep AR, Karvekar S, Nagpal K, Patnaik K, Raju A, Singh P. Rosuvastatin 1.2 mg In Situ Gel Combined With 1:1 Mixture of Autologous Platelet-Rich Fibrin and Porous Hydroxyapatite Bone Graft in Surgical Treatment of Mandibular Class II Furcation Defects: A Randomized Clinical Control Trial. J Periodontol. 2016; 87: 5-13.
[23] Anitua E. Plasma rich in growth factors: preliminary results of use in the preparation of future sites for implants. Int J Oral Maxillofac Implants. 1999; 14: 529-535.
[24] Panda S, Purkayastha A, Mohanty R, Nayak R, Satpathy A, Das AC, et al. Plasma rich in growth factors (PRGF) in non-surgical periodontal therapy: a randomized clinical trial. Braz Oral Res. 2020; 34: 1-10.
[25] Shirke PY, Kolte AP, Kolte RA, Bawanakar PV. Evaluation of the clinical efficacy of 1.2% atorvastatin in the treatment of periodontal intraosseous defects by CBCT: A randomized controlled clinical trial. J Dent Res Dent Clin Dent Prospects. 2019; 13: 183-191.
[26] Kanoriya D, Bajaj N, Pradeep A. 1.2% rosuvastatin gel as a local drug delivery agent in smokers with chronic periodontitis: a randomized controlled clinical trial. JCRI. 2019; 6: 110-115.
[27] Cao R, Li Q, Chen Y, Yao M, Wu Q, Zhou H. Efficacy of locally-delivered statins adjunct to non-surgical periodontal therapy for chronic periodontitis: a Bayesian network analysis. BMC Oral Health. 2019; 19: 105.
[28] Bojarpour M, Jenabian N, Haghanifar S, Khafri S. The effect of plasma rich in growth factors (PRGF) in the treatment of periodontal three-walled intrabony defects. Caspian J Dent Res. 2018; 7: 14-20.
[29] Löe H. The Gingival Index, the Plaque Index and the Retention Index Systems. J Periodontol. 1967; 38: Suppl: 610-616.
[30] Anitua E. The use of plasma-rich growth factors (PRGF) in oral surgery. Pract Proced Aesthet Dent. 2001; 13: 487-493.
[31] Kumar K, Dhawan N, Sharma H, Vaidya S, Vaidya B. Bioadhesive polymers: novel tool for drug delivery. Artif Cells Nanomed Biotechnol. 2014; 42: 274-283.
[32] Hashemi M, Ramezani V, Seyedabadi M, Ranjbar AM, Jafari H, Honarvar M, et al. Formulation and Optimization of Oral Mucoadhesive Patches of Myrtus Communis by Box Behnken Design. Adv Pharm Bull. 2017; 7: 441-450.
[33] Pradeep AR, Pai S, Garg G, Devi P, Shetty SK. A randomized clinical trial of autologous platelet-rich plasma in the treatment of mandibular degree II furcation defects. J Clin Periodontol. 2009; 36: 581-588.
[34] Martande SS, Kumari M, Pradeep AR, Singh SP, Suke DK, Guruprasad CN. Platelet-Rich Fibrin Combined With 1.2% Atorvastatin for Treatment of Intrabony Defects in Chronic Periodontitis: A Randomized Controlled Clinical Trial. J Periodontol. 2016; 87: 1039-1046.
[35] Akram Z, Vohra F, Javed F. Efficacy of statin delivery as an adjunct to scaling and root planing in the treatment of chronic periodontitis: A meta-analysis. J Investig Clin Dent. 2018; 9: e12304.
[36] Sinjab K, Zimmo N, Lin GH, Chung MP, Shaikh L, Wang HL. The Effect of Locally Delivered Statins on Treating Periodontal Intrabony Defects: A Systematic Review and Meta-Analysis. J Periodontol. 2017; 88: 357-367.
[37] Pradeep AR, Kumari M, Rao NS, Martande SS, Naik SB. Clinical efficacy of subgingivally delivered 1.2% atorvastatin in chronic periodontitis: a randomized controlled clinical trial. J Periodontol. 2013; 84: 871-879. | ||
|
آمار تعداد مشاهده مقاله: 1,309 تعداد دریافت فایل اصل مقاله: 1,077 |
||
