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The Effect of Combined Exercise Training with Zataria Multiflora on RBP- 4 and Resistin Levels in Sedentary Women: a Randomized Double-blind Clinical Trial | ||
Women’s Health Bulletin | ||
مقاله 4، دوره 9، شماره 1 - شماره پیاپی 32، فروردین 2022، صفحه 24-33 اصل مقاله (610.85 K) | ||
نوع مقاله: Research Article | ||
شناسه دیجیتال (DOI): 10.30476/whb.2022.93579.1153 | ||
نویسندگان | ||
Forough Darabi؛ Mandana Gholami* ؛ Hossein Abed Natanzi | ||
Department of Physical Education and Sport Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran | ||
چکیده | ||
Background: Exercise training and zataria multiflora exert anti-inflammatory effects alone and together; these anti-inflammatory effects are partly related to modulating adipokines secretion from adipose tissue. This research aimed to investigate the effect of combined training (aerobic-resistance) and zataria multiflora supplementation on serum resistin and retinol binding protein 4 (RBP-4) in sedentary women. Methods: The present randomized clinical trial, under the registration number IRCT20200812048388N1, was conducted in the winter and spring of 2021. The participants included 40 overweight and obese women who were assigned in four groups (10 women in each group), namely combined training with zataria multiflora (TZ), combined training (T), zataria multiflora (Z), and placebo (C) groups. Each combined training session consisted of 30 min of aerobic exercise, followed by 30 min of resistance exercise. Zataria multiflora supplement was also consumed at 500 mg daily. We carried out blood sampling before and after (48 hours after the last training session) the intervention period and measured the serum levels of RBP-4 and resistin via ELISA method. For data analysis, the SPSS software version 24, and analysis of covariance (ANCOVA) with Bonferroni post-hoc tests were used. Results: We observed a significant decrease in RBP-4 levels of T compared to that of C group (P=0.045), and in TZ compared to C and Z groups (p <0.001). In addition, the obtained findings indicated a significant decrease in resistin of T compared to that of C group (P=0.046), and in TZ group compared to C and Z groups (p <0.001). In addition, there was a significant decrease in HOMA-IR of T and TZ groups compared to that of C and Z groups (p <0.05). Conclusion: According to the results, Zataria multiflora supplementation amplified the anti-inflammatory properties of combined training and combined training effect in insulin resistance improvement. Furthermore, it was found to have a synergistic effect along with combined training. | ||
کلیدواژهها | ||
Exercise training؛ Adipokines؛ Inflammation؛ Resistin | ||
مراجع | ||
1. Withrow D, Alter DA. The economic burden of obesity worldwide: a systematic review of the direct costs of obesity. Obes Rev. 2011;12(2):131-41. doi: 10.1111/j.1467-789X.2009.00712.x. PubMed PMID: 20122135. ## 2. Włodarczyk M, Nowicka G. Obesity, DNA damage, and development of obesity-related diseases. Int J Mol Sci. 2019;20(5):1146. doi: 10.3390/ijms20051146. PubMed PMID: 30845725; PubMed Central PMCID: PMC6429223. ## 3. de Oliveira Leal V, Mafra D. Adipokines in obesity. Clin Chim Acta. 2013;419:87-94. doi: 10.1016/j.cca.2013.02.003. PubMed PMID: 23422739. ## 4. Maury E, Brichard SM. Adipokine dysregulation, adipose tissue inflammation and metabolic syndrome. Mol Cell Endocrinol. 2010;314(1):1-6 doi: 10.1016/j.mce.2009.07.031. PubMed PMID: 19682539. ## 5. Trayhurn P, Wood IS. Adipokines: inflammation and the pleiotropic role of white adipose tissue. Br J Nutr. 2004;92(3):347-55. doi: 10.1079/bjn20041213. PubMed PMID: 15469638. ## 6. Gnacińska M, Małgorzewicz S, Stojek M, Łysiak-Szydłowska W, Sworczak K. Role of adipokines in complications related to obesity. a review. Adv Med Sci. 2009;54(2):150-7. doi: 10.2478/v10039-009-0035-2. PubMed PMID: 19875356. ## 7. Zabetian-Targhi F, Mahmoudi MJ, Rezaei N, Mahmoudi M. Retinol binding protein 4 in relation to diet, inflammation, immunity, and cardiovascular diseases. Adv Nutr. 2015;6(6):748-62. doi: 10.3945/an.115.008292. PubMed PMID: 26567199; PubMed Central PMCID: PMC4642414. ## 8. Klöting N, Graham TE, Berndt J, Kralisch S, Kovacs P, Wason CJ, et al. Serum retinol-binding protein is more highly expressed in visceral than in subcutaneous adipose tissue and is a marker of intra-abdominal fat mass. Cell Metabol. 2007;6(1):79-87. doi: 10.1016/j.cmet.2007.06.002. PubMed PMID: 17618858. ## 9. Balagopal P, Graham TE, Kahn BB, Altomare A, Funanage V, George D. Reduction of elevated serum retinol binding protein in obese children by lifestyle intervention: association with subclinical inflammation. J Clin Endocrinol Metab. 2007;92(5):1971-4. doi: 10.1210/jc.2006-2712. PubMed PMID: 17341558. ## 10. Bokarewa M, Nagaev I, Dahlberg L, Smith U, Tarkowski A. Resistin, an adipokine with potent proinflammatory properties. J Immunol. 2005;174(9):5789-95. doi: 10.4049/jimmunol.174. 9.5789. PubMed PMID: 15843582. ## 11. Badoer E, Kosari S, Stebbing MJ. Resistin, an adipokine with non-generalized actions on sympathetic nerve activity. Front Physiol. 2015; 6:321. doi: 10.3389/fphys.2015.00321. PubMed PMID: 26617526; PubMed Central PMCID: PMC4639629. ## 12. Schwartz DR, Lazar MA. Human resistin: found in translation from mouse to man. Trends Endocrinol. Metab. 2011;22(7):259-65. doi: 10.1016/j.tem.2011.03.005. PubMed PMID: 21497511; PubMed Central PMCID: PMC3130099. ## 13. Chen N, Zhou L, Zhang Z, Xu J, Wan Z, Qin L. Resistin induces lipolysis and suppresses adiponectin secretion in cultured human visceral adipose tissue. Regul Pept. 2014;194-195:49-54. doi: 10.1016/j.regpep.2014.10.001. PubMed PMID: 25454366. ## 14. Liu Y, Wang Q, Pan YB, Gao ZJ, Liu YF, Chen SH. Effects of over-expressing resistin on glucose and lipid metabolism in mice. J Zhejiang Univ Sci B. 2008;9(1):44-50. doi: 10.1631/jzus. B071479. PubMed PMID: 18196612; PubMed Central PMCID: PMC2170468. ## 15. Kim HS, Sung HY, Kim MS, Kim JL, Kang MK, Gong JH, et al. Oleanolic acid suppresses resistin induction in adipocytes by modulating Tyk-STAT signaling. Nutr Res. 2013;33(2):144-53. doi: 10.1016/j.nutres.2012.12.006. PubMed PMID: 23399665. ## 16. Biddle SJ, Bengoechea EG, Pedisic Z, Bennie J, Vergeer I, Wiesner G. Screen time, other sedentary behaviours, and obesity risk in adults: a review of reviews. Curr Obes Rep. 2017;6(2):134-147. doi: 10.1007/s13679-017-0256-9. PubMed PMID: 28421472. ## 17. Soltani N, Marandi SM, Kazemi M, Esmaeil N. The exercise training modulatory effects on the obesity-induced immunometabolic dysfunctions. Diabetes Metab Syndr Obes. 2020;13:785-810. doi: 10.2147/DMSO.S234992. PubMed PMID: 32256095; PubMed Central PMCID: PMC7090203. ## 18. Khazdair MR, Ghorani V, Alavinezhad A, Boskabady MH. Pharmacological effects of Zataria multiflora Boiss L. and its constituents focus on their anti‐inflammatory, antioxidant, and immunomodulatory effects. Fundam Clin Pharmacol. 2018;32(1):26-50. doi: 10.1111/fcp.12331. PubMed PMID: 29125648. ## 19. Mohammadi A, Gholamhoseinian A, Fallah H. Zataria multiflora increases insulin sensitivity and PPARγ gene expression in high fructose fed insulin resistant rats. Iran J Basic Med Sci. 2014;17(4):263-70. PubMed PMID: 24904719; PubMed Central PMCID: PMC4046234. ## 20. Tayebi SM, Hasannezhad P, Saeidi A, Fadaei MR. Intense circuit resistance training along with Zataria multiflora supplementation reduced plasma retinol binding protein-4 and tumor necrosis factor-α in postmenopausal females. Jundishapur J Nat Pharm Prod. 2018;13(2):e38578. doi: 10.17795/jjnpp.38578. ## 21. Schroeder EC, Franke WD, Sharp RL, Lee DC. Comparative effectiveness of aerobic, resistance, and combined training on cardiovascular disease risk factors: A randomized controlled trial. PloS One. 2019;14(1):e0210292. doi: 10.1371/journal.pone.0210292. PubMed PMID: 30615666; PubMed Central PMCID: PMC6322789. ## 22. Duft RG, Castro A, Bonfante IL, Lopes WA, da Silva LR, Chacon-Mikahil MP, et al. Altered metabolomic profiling of overweight and obese adolescents after combined training is associated with reduced insulin resistance. Sci Rep. 2020;10(1):16880. doi: 10.1038/s41598-020-73943-y. PubMed PMID: 33037261; PubMed Central PMCID: PMC7547065. ## 23. Gholaman M, Gholami M, Azarbayjani MA, Abed Natanzi H. High and Moderate Intensity Aerobic Training Effects on Galectin-3, Pentraxin-3, and Several Inflammatory Mediators Levels in Type 2 Diabetic Women, a Randomized Clinical Trial. Women Health Bull. 2021;8(4):238-246. doi: 10.30476/WHB.2021.91832.1134. ## 24. Ghanbari-Niaki A, Saeidi A, Ahmadian M, Gharahcholo L, Naghavi N, Fazelzadeh M, et al. The combination of exercise training and Zataria multiflora supplementation increase serum irisin levels in postmenopausal women. Integr Med Res. 2018;7(1):44-52. doi: 10.1016/j.imr. 2018.01.007. PubMed PMID: 29629290; PubMed Central PMCID: PMC5884011. ## 25. Rezai N, Abedi B, Fatolahi H. Effect of Eight Weeks of Aerobic Aquatic and Land Exercise Training on Leptin, Resistin, and Insulin Resistance in Obese Women. Research on Medicine. 2019;43(2):83-89. Persian. ## 26. Kazemi A, Rostami R, Koushkie Jahromi M, Tahmasebi S. Does Pilates Exercise Change the Memory, Attention and Balance in Women with Lymphedema after Modified Mastectomy? Women Health Bull. 2021;8(1):56-62. doi: 10.30476/WHB.2021.88043.1083. ## 27. Seo DI, So WY, Ha S, Yoo EJ, Kim D, Singh H, et al. Effects of 12 weeks of combined exercise training on visfatin and metabolic syndrome factors in obese middle-aged women. J Sports Sci Med. 2011;10(1):222-6. PubMed PMID: 24149317; PubMed Central PMCID: PMC3737906. ## 28. Azizi M, Tadibi V, Behpour N. The effect of aerobic exercise training on β-cell function and circulating levels of adipsin in community of obese women with type 2 diabetes mellitus. International Journal of Diabetes in Developing Countries. 2017;37(3):298-304. doi: 10.1007/s13410-016-0504-7. ## 29. Christou GA, Tselepis AD, Kiortsis DN. The metabolic role of retinol binding protein 4: an update. Horm Metab Res. 2012;44(01):6-14. doi: 10.1055/s-0031-1295491. ## 30. Babaei Bonab S, Tofighi A, Tolouei Azar J. The effect of 12 weeks of Aqua training on RBP4, insulin resistance, and liver enzymes in women with type 2 diabetes. Stud Med Sci. 2019;30(4):290-299. Persian. ## 31. Hosseini SA, Shadmehri S, Rahimi Bazkhaneh Z, Rahmani M, Kazemi N. The Effect of Eight Weeks of Combined Exercise on Retinol Binding Protein 4, Fatty Acid Binding Protein and Lipocalin-2 in Type 2 Diabetic Women (Clinical Trial). Thrita. 2018;7(2):e84879. doi: 10.5812/thrita.84879. ## 32. Tschoner A, Sturm W, Engl J, Kaser S, Laimer M, Laimer E, et al. Retinol‐binding protein 4, visceral fat, and the metabolic syndrome: effects of weight loss. Obesity. 2008;16(11):2439-44. doi: 10.1038/oby.2008.391. PubMed PMID: 18719670. ## 33. Tayebi SM, Saeidi A, Fashi M, Pouya S, Khosravi A, Shirvani H, et al. Plasma retinol-binding protein-4 and tumor necrosis factor-α are reduced in postmenopausal women after combination of different intensities of circuit resistance training and Zataria supplementation. Sport Sci Health. 2019;15(3):551-558. doi: 10.1007/s11332-019-00544-2. PubMed PMID: 31885723; PubMed Central PMCID: PMC6934256. ## 34. Moghadasi M, Nuri R, Ahmadi N. Effects of 8 weeks high intensity aerobic exercise on serum retinol binding protein 4 levels in female athletes. Brazilian Journal of Biomotricity. 2013;7(1):37-42. ## 35. Janke J, Engeli S, Boschmann M, Adams F, Böhnke J, Luft FC, et al. Retinol-binding protein 4 in human obesity. Diabetes. 2006;55(10):2805-10. doi: 10.2337/db06-0616. PubMed PMID: 17003346. ## 36. Vaisbuch E, Mazaki-Tovi S, Kusanovic JP, Erez O, Than NG, Kim S, et al. Retinol binding protein 4: An adipokine associated with intra-amniotic infection/inflammation. J Matern Fetal Neonatal Med. 2010;23(2):111–9. doi: 10.3109/14767050902994739. PubMed PMID: 19900011; PubMed Central PMCID: PMC3578505. ## 37. Kanoriya D, Pradeep AR, Mallika A, Singhal S, Garg V. Correlation of crevicular fluid and serum levels of retinol-binding protein 4 and leptin in chronic periodontitis and obesity. Clin Oral Investig. 2017;21(7):2319-2325. doi: 10.1007/s00784-016-2025-7. PubMed PMID: 27933445. ## 38. Kadoglou NP, Perrea D, Iliadis F, Angelopoulou N, Liapis C, Alevizos M. Exercise reduces resistin and inflammatory cytokines in patients with type 2 diabetes. Diabetes Care. 2007;30(3):719-21. doi: 10.2337/dc06-1149. PubMed PMID: 17327348. ## 39. McTernan PG, McTernan CL, Chetty R, Jenner K, Fisher FM, Lauer MN, et al. Increased resistin gene and protein expression in human abdominal adipose tissue. J Clin Endocrinol Metab. 2002;87(5):2407. doi: 10.1210/jcem.87.5.8627. PubMed PMID: 11994397. ## 40. Afshounpour MT, Habibi A, Ranjbar R. Impact of combined exercise training on plasma concentration of Apelin, resistin and insulin resistance in patients with type 2 diabetics’ male. Bimonthly Journal of Hormozgan University of Medical Sciences. 2016;20(3):158-69. ## 41. Lopes WA, Leite N, da Silva LR, Brunelli DT, Gáspari AF, Radominski RB, et al. Effects of 12 weeks of combined training without caloric restriction on inflammatory markers in overweight girls. J Sports Sci. 2016;34(20):1902-12. doi: 10.1080/02640414.2016.1142107. PubMed PMID: 26852885. ## 42. Sadashiv ST, Paul BN, Kumar S, Chandra A, Dhananjai S, Negi MP. Over expression of resistin in adipose tissue of the obese induces insulin resistance. World J Diabetes. 2012;3(7):135-41. doi: 10.4239/wjd. v3.i7.135. PubMed PMID: 22816026; PubMed Central PMCID: PMC3399912. ## 43. Saeidi A, Jabbour G, Ahmadian M, Abbassi-Daloii A, Malekian F, Hackney AC, et al. Independent and Combined Effects of Antioxidant Supplementation and Circuit Resistance Training on Selected Adipokines in Postmenopausal Women. Front Physiol. 2019;10:484. doi: 10.3389/fphys.2019.00484. PubMed PMID: 31105587; PubMed Central PMCID: PMC6499001. ## 44. Farinha JB, Steckling FM, Stefanello ST, Cardoso MS, Nunes LS, Barcelos RP, et al. Response of oxidative stress and inflammatory biomarkers to a 12-week aerobic exercise training in women with metabolic syndrome. Sports Med Open. 2015;1(1):19. doi: 10.1186/s40798-015-0011-2. PubMed PMID: 26284160; PubMed Central PMCID: PMC5005613. ## 45. Kawanishi N, Yano H, Yokogawa Y, Suzuki K. Exercise training inhibits inflammation in adipose tissue via both suppression of macrophage infiltration and acceleration of phenotypic switching from M1 to M2 macrophages in high-fat-diet-induced obese mice. Exerc Immunol Rev. 2010;16:105-18. PubMed PMID: 20839495. ## | ||
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