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Mohamed, Asmaa, Harb, Ola, Hemeda, Rehab, Sharafedeen, Mahmoud, Abd-Elhady, Waleed, Ali, Ramadan. (1401). Prognostic Performance of High Expression of KIF23 and Loss of c-CBL in Gastric Cancer Patients: An Immunohistochemical Study. سامانه مدیریت نشریات علمی, 13(3), 393-403. doi: 10.30476/mejc.2022.87766.1434
Asmaa Hussein Mohamed; Ola A. Harb; Rehab Hemeda; Mahmoud Sharafedeen; Waleed A. Abd-Elhady; Ramadan M. Ali. "Prognostic Performance of High Expression of KIF23 and Loss of c-CBL in Gastric Cancer Patients: An Immunohistochemical Study". سامانه مدیریت نشریات علمی, 13, 3, 1401, 393-403. doi: 10.30476/mejc.2022.87766.1434
Mohamed, Asmaa, Harb, Ola, Hemeda, Rehab, Sharafedeen, Mahmoud, Abd-Elhady, Waleed, Ali, Ramadan. (1401). 'Prognostic Performance of High Expression of KIF23 and Loss of c-CBL in Gastric Cancer Patients: An Immunohistochemical Study', سامانه مدیریت نشریات علمی, 13(3), pp. 393-403. doi: 10.30476/mejc.2022.87766.1434
Mohamed, Asmaa, Harb, Ola, Hemeda, Rehab, Sharafedeen, Mahmoud, Abd-Elhady, Waleed, Ali, Ramadan. Prognostic Performance of High Expression of KIF23 and Loss of c-CBL in Gastric Cancer Patients: An Immunohistochemical Study. سامانه مدیریت نشریات علمی, 1401; 13(3): 393-403. doi: 10.30476/mejc.2022.87766.1434

Prognostic Performance of High Expression of KIF23 and Loss of c-CBL in Gastric Cancer Patients: An Immunohistochemical Study

Middle East Journal of Cancer
مقاله 2، دوره 13، شماره 3 - شماره پیاپی 51، مهر 2022، صفحه 393-403    اصل مقاله (16.38 M)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/mejc.2022.87766.1434
نویسندگان
Asmaa Hussein Mohamed1؛ Ola A. Harb* 1؛ Rehab Hemeda2؛ Mahmoud Sharafedeen3؛ Waleed A. Abd-Elhady4؛ Ramadan M. Ali4
1Department of Pathology, Faculty of Medicine, Zagazig University, Zagazig, Egypt
2Department of Clinical Oncology and Nuclear Medicine, Faculty of Medicine, Zagazig University, Zagazig, Egypt
3Department of Internal Medicine, Faculty of Medicine, Zagazig University, Zagazig, Egypt
4Department of General Surgery, Faculty of Medicine, Zagazig University, Zagazig, Egypt
چکیده
Background: Kinesin family member 23 (KIF23) has an important role in mitosis of cytoplasmic separation process. Casitas B-lineage lymphoma (c-Cbl) is a protein ligase E3 ubiquitin in tyrosine kinase pathways, involved in numerous cell types.
The current study aimed to evaluate the tissue expression of KIF23 and c-Cbl in gastric cancer (GC) tissues and normal gastric mucosa using immunohistochemistry and to investigate the correlation among their expressions, clinicopathological parameters, and the prognosis of patients in order to detect their role in the progression of GC and patientsi prognosis.
Method: We conducted this prospective study on 120 samples retrieved from 120 patients; 80 samples were taken from GC patients and 40 from normal gastric mucosa. We assed tissue protein expression of KIF23 and c-Cbl using immunohistochemistry. We evaluated the correlations between KIF23 and C-Cbl expression with clinicopathological and prognostic parameters of patients.
Results: KIF23 expression level in GC tissues was positively correlated with high pTNM stage (P = 0.001), larger tumor size (P = 0.010), high tumor grade (P = 0.006), poor overall survival (P < 0.001), disease-free survival rates (P = 0.003), and tumor recurrence after therapy (P = 0.004). c-Cbl expression level in GC tissues was positively correlated with early pTNM stage (P = 0.003), lower tumor grade (P = 0.005), the absence of lymph node metastasis (P = 0.023), good response to therapy (P = 0.002), and the absence of tumor recurrence after the therapy (P = 0.004).
Conclusion: The high KIF23 expression and low c-Cbl expression in GC tissues were attributed to progression and poor prognosis in gastric cancer patients.
کلیدواژه‌ها
Stomach neoplasms؛ KIF23؛ C-Cbl؛ Immunohistochemistry؛ Prognosis
اصل مقاله

How to cite this article:

Mohamed AH, Harb OA, Hemeda R, Sharafedeen M, Abd-Elhady WA, Ali RM. Prognostic performance of high expression of KIF23 and loss of c-CBL in gastric cancer patients: An immunohistochemical study. Middle East J Cancer. 2022;13(3):393-403. doi: 10.30476/mejc.2022.87766.1434.

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