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Sivandzadeh, Gholam Reza, Mehrabi, Manoosh, Safarpour, Ali Reza, Ashrafizadeh, Hadis, Keshtkar, Abbas Ali, Shojaei-Zarghani, Sara. (1400). Does the inflammatory bowel disease activity alter following liver transplantation? A protocol for systematic review and meta-analysis. سامانه مدیریت نشریات علمی, 9(4), 144-148. doi: 10.30476/acrr.2022.93175.1118
Gholam Reza Sivandzadeh; Manoosh Mehrabi; Ali Reza Safarpour; Hadis Ashrafizadeh; Abbas Ali Keshtkar; Sara Shojaei-Zarghani. "Does the inflammatory bowel disease activity alter following liver transplantation? A protocol for systematic review and meta-analysis". سامانه مدیریت نشریات علمی, 9, 4, 1400, 144-148. doi: 10.30476/acrr.2022.93175.1118
Sivandzadeh, Gholam Reza, Mehrabi, Manoosh, Safarpour, Ali Reza, Ashrafizadeh, Hadis, Keshtkar, Abbas Ali, Shojaei-Zarghani, Sara. (1400). 'Does the inflammatory bowel disease activity alter following liver transplantation? A protocol for systematic review and meta-analysis', سامانه مدیریت نشریات علمی, 9(4), pp. 144-148. doi: 10.30476/acrr.2022.93175.1118
Sivandzadeh, Gholam Reza, Mehrabi, Manoosh, Safarpour, Ali Reza, Ashrafizadeh, Hadis, Keshtkar, Abbas Ali, Shojaei-Zarghani, Sara. Does the inflammatory bowel disease activity alter following liver transplantation? A protocol for systematic review and meta-analysis. سامانه مدیریت نشریات علمی, 1400; 9(4): 144-148. doi: 10.30476/acrr.2022.93175.1118

Does the inflammatory bowel disease activity alter following liver transplantation? A protocol for systematic review and meta-analysis

Iranian Journal of Colorectal Research
مقاله 2، دوره 9، شماره 4، اسفند 2021، صفحه 144-148    اصل مقاله (654.5 K)
نوع مقاله: Protocol
شناسه دیجیتال (DOI): 10.30476/acrr.2022.93175.1118
نویسندگان
Gholam Reza Sivandzadeh1؛ Manoosh Mehrabi2؛ Ali Reza Safarpour* 1؛ Hadis Ashrafizadeh3؛ Abbas Ali Keshtkar4؛ Sara Shojaei-Zarghani1
1Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
2Department of E-Learning, Virtual school, Shiraz University of Medical Sciences, Shiraz, Iran
3Department of Nursing, School of Nursing and Midwifery, Student Research Committee, Ahvaz Jundishapur University of Medical Science, Ahvaz, Iran
4Department of Health Sciences Education Development, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
چکیده
Background& Aims: Inflammatory bowel disease (IBD) is closely associated with primary sclerosing cholangitis (PSC), an uncommon chronic and progressive cholestatic liver disease. Liver transplantation (LT) is the only therapeutic strategy for PSC that may also affect the IBD course. Considering the lack of any systematic review and pursuing debate on the alterations in the clinical course of IBD after LT compared to before, we aim to systematically assess the frequencies of patients with "improved", "unchanged", or "aggravated" IBD course following LT and conduct a meta-analysis.
Methods: In this systematic review, PubMed/MEDLINE, Scopus, WoS (Clarivate Analytics), and Embase will be searched. Our search strategy (i.e. the eligibility criteria) covers prospective and retrospective observational studies evaluating the clinical course of ulcerative colitis or/and Crohn’s disease after LT, with no language limitation, published between 01.01.1970 and 30.12.2020. The selection phase, data extraction, and quality assessment will be independently implemented by two authors. In case of any disagreement between the authors, the issue will be resolved by consensus; if not resolved, the opinion of a third expert person will be asked. If there are sufficient studies, the pooled frequencies (%) of patients with "improved", "unchanged", or "exacerbated" IBD activity following LT will be calculated using random-effects meta-analysis due to the expected heterogeneity. Forest plots will show the separated and combined frequencies and their corresponding 95% CIs. Statistical heterogeneity will be evaluated by the Q-statistic test and I2 statistics. The funnel plot for assessing the potential reporting bias, Begg's and Egger's tests for meaningful results of the publication bias, and the Fill & Trim method for corrected publication bias will be used.
کلیدواژه‌ها
Liver Transplantation؛ Inflammatory bowel disease, Primary Sclerosing Cholangitis؛ Crohn’s Disease؛ Ulcerative Colitis
مراجع
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تعداد مشاهده مقاله: 318
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