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Zhaeintan, Parisa, Nickfarjam, Abolfazl, Shams, Ali, Abdollahi-Dehkordi, Sepideh, Hamzian, Nima. (1401). Radioprotective Effect of Rosmarinus officinalis L (Rosemary) Essential Oil on Apoptosis, Necrosis and Mitotic Death of Human Peripheral Lymphocytes (PBMCs). سامانه مدیریت نشریات علمی, 12(3), 245-256. doi: 10.31661/jbpe.v0i0.2105-1333
Parisa Zhaeintan; Abolfazl Nickfarjam; Ali Shams; Sepideh Abdollahi-Dehkordi; Nima Hamzian. "Radioprotective Effect of Rosmarinus officinalis L (Rosemary) Essential Oil on Apoptosis, Necrosis and Mitotic Death of Human Peripheral Lymphocytes (PBMCs)". سامانه مدیریت نشریات علمی, 12, 3, 1401, 245-256. doi: 10.31661/jbpe.v0i0.2105-1333
Zhaeintan, Parisa, Nickfarjam, Abolfazl, Shams, Ali, Abdollahi-Dehkordi, Sepideh, Hamzian, Nima. (1401). 'Radioprotective Effect of Rosmarinus officinalis L (Rosemary) Essential Oil on Apoptosis, Necrosis and Mitotic Death of Human Peripheral Lymphocytes (PBMCs)', سامانه مدیریت نشریات علمی, 12(3), pp. 245-256. doi: 10.31661/jbpe.v0i0.2105-1333
Zhaeintan, Parisa, Nickfarjam, Abolfazl, Shams, Ali, Abdollahi-Dehkordi, Sepideh, Hamzian, Nima. Radioprotective Effect of Rosmarinus officinalis L (Rosemary) Essential Oil on Apoptosis, Necrosis and Mitotic Death of Human Peripheral Lymphocytes (PBMCs). سامانه مدیریت نشریات علمی, 1401; 12(3): 245-256. doi: 10.31661/jbpe.v0i0.2105-1333

Radioprotective Effect of Rosmarinus officinalis L (Rosemary) Essential Oil on Apoptosis, Necrosis and Mitotic Death of Human Peripheral Lymphocytes (PBMCs)

Journal of Biomedical Physics and Engineering
مقاله 4، دوره 12، شماره 3، شهریور 2022، صفحه 245-256    اصل مقاله (1.58 M)
نوع مقاله: Original Research
شناسه دیجیتال (DOI): 10.31661/jbpe.v0i0.2105-1333
نویسندگان
Parisa Zhaeintan1؛ Abolfazl Nickfarjam2؛ Ali Shams3؛ Sepideh Abdollahi-Dehkordi4؛ Nima Hamzian* 2
1MSc, Department of Medical Physics, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
2PhD, Department of Medical Physics, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
3PhD, Department of Immunology, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
4PhD Candidate, Department of Medical Physics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
چکیده
Background: Rosemary plant, with phenolic compounds, is known as an antioxidant herb and able to scavenge free radical agents in the biological environment; therefore, it is expected that the rosemary essential oil (R-EO) shows the radioprotective effect to protect individuals who are physically in contact with ionizing radiation.
Objective: This study aimed to assess the radioprotective effect of R-EO on human peripheral blood mononuclear cells (PBMCs).
Material and Methods: In this experimental study, the toxicity of the rosemary essential oil on PBMCs was assessed by the 3-(4, 5-dimethylthiazolyl-2)-2, 5-diphenyltetrazolium bromide (MTT) assay. The cells were irradiated at 0. 25 and 200 cGy using a 6 MV X-ray linear accelerator. The survival, apoptosis, necrosis, and survival enhancement factors of cells were analyzed by MTT and flow cytometry analyses with a non-toxic concentration of the rosemary essential oil (IC10).
Results: Irradiation of cells in the presence of R-EO caused a significant increase in cell survival compared with the control in both 25 and 200 cGy radiation doses. Also, the percentages of apoptosis and necrosis of cells showed a significant decrease compared with the control.
Conclusion: Rosemary essential oil as a natural and non-toxic compound could show favorable radioprotective effects in such a way that significantly increases the survival rate and decreases the percentage of apoptosis and necrosis of PBMCs.
کلیدواژه‌ها
Ionizing Radiation؛ Radioprotective Agent؛ Rosemary Plant؛ Apoptosis and Necrosis؛ Peripheral Lymphocyte
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مراجع
  1. Islamian JP, Farajollahi A, Mehrali H, Hatamian M. Radioprotective effects of amifostine and lycopene on human peripheral blood lymphocytes in vitro. J Med Imaging Radiat Sci. 2016;47(1):49-54. doi: 10.1016/j.jmir.2015.10.006. PubMed PMID: 31047163.
  2. Hall EJ, Giaccia AJ. Radiobiology for the Radiologist. 6rd ed. Philadelphia: Lippincott Williams & Wilkins; 2006.
  3. Fardid R, Ghorbani Z, Haddadi G, Behzad-Behbahani A, Arabsolghar R, Kazemi E, et al. Effects of hesperidin as a radio-protector on apoptosis in rat peripheral blood lymphocytes after gamma radiation. J Biomed Phys Eng. 2016;6(4):217-28. PubMed PMID: 28144590. PubMed PMCID: PMC5219572.
  4. Jagetia GC. Radioprotective potential of plants and herbs against the effects of ionizing radiation. J Clin Biochem Nutr. 2007;40(2):74-81. doi: 10.3164/jcbn.40.74. PubMed PMID: 18188408. PubMed PMCID: PMC2127223.
  5. Hamzian N, Hashemi M, Ghorbani M, Bahreyni Toosi M H, Ramezani M. Preparation, Optimization and Toxicity Evaluation of (SPION-PLGA) ±PEG Nanoparticles Loaded with Gemcitabine as a Multifunctional Nanoparticle for Therapeutic and Diagnostic Applications. Iran J Pharm Res. 2017;16(1):8-21. PubMed PMID: 28496458. PubMed PMCID: PMC5423230
  6. Hamzian N, Hashemi M, Ghorbani M, Aledavood SA, Ramezani M, Bahreyni Toosi MH. In-vitro Study of Multifunctional PLGA-SPION Nanoparticles Loaded with Gemcitabine as Radiosensitizer Used in Radiotherapy. Iran J Pharm Res. 2019;18(4):1694-703. doi: 10.22037/ijpr.2019.14050.12131. PubMed PMID: 32184839. PubMed PMCID: PMC7059059.
  7. Cheki M, Mihandoost E, Shirazi A, Mahmoudzadeh A. Prophylactic role of some plants and phytochemicals against radio-genotoxicity in human lymphocytes. J Can Res Ther. 2016;12(4):1234-42. doi: 10.4103/0973-1482.172131. PubMed PMID: 28169233.
  8. Turner ND, Braby LA, Ford J, Lupton JR. Opportunities for nutritional amelioration of radiation-induced cellular damage. Nutrition. 2002;18(10):904-12. doi: 10.1016/s0899-9007(02)00945-0. PubMed PMID: 12361786.
  9. Maurya DK, Devasagayam T, Nair CKK. Some novel approaches for radioprotection and the beneficial effect of natural products. Indian J Exp Biol. 2006;44(2):93-114. PubMed PMID: 16480175.
  10. Hosseinimehr SJ. Trends in the development of radioprotective agents. Drug Discov Today. 2007;12(19-20):794-805. doi: 10.1016/j.drudis.2007.07.017. PubMed PMID: 17933679.
  11. Brewer M. Natural antioxidants: sources, compounds, mechanisms of action, and potential applications. Compr Rev Food Sci F. 2011;10(4):221-47. doi: 10.1111/j.1541-4337.2011.00156.x.
  12. Hassani FV, Shirani K, Hosseinzadeh H. Rosemary (Rosmarinus officinalis) as a potential therapeutic plant in metabolic syndrome: a review. Naunyn Schmiedebergs Arch Pharmacol. 2016;389(9):931-49. doi: 10.1007/s00210-016-1256-0. PubMed PMID: 27178264.
  13. Andrade JM, Faustino C, Garcia C, Ladeiras D, Reis CP, Rijo P. Rosmarinus officinalis L.: an update review of its phytochemistry and biological activity. Future Sci OA. 2018;4(4):FSO283. doi: 10.4155/fsoa-2017-0124. PubMed PMID: 29682318. PubMed PMCID: PMC5905578.
  14. Miraj S. An evidence-based review on herbal remedies of Rosmarinus officinalis. Der Pharmacia Lettre. 2016;8(19):426-36.
  15. Rao BR, Kaul P, Syamasundar K, Ramesh S. Chemical profiles of primary and secondary essential oils of palmarosa (Cymbopogon martinii (Roxb.) Wats var. motia Burk.). Ind Crop Prod. 2005;21(1):121-7. doi: 10.1016/j.indcrop.2004.02.002.
  16. Reisz JA, Bansal N, Qian J, Zhao W, Furdui CM. Effects of ionizing radiation on biological molecules--mechanisms of damage and emerging methods of detection. Antioxid Redox Signal. 2014;21(2):260-92. doi: 10.1089/ars.2013.5489. PubMed PMID: 24382094. PubMed PMCID: PMC4060780.
  17. Xu D-P, Li Y, Meng X, Zhou T, Zhou Y, Zheng J, et al. Natural antioxidants in foods and medicinal plants: Extraction, assessment and resources. Int J Mol Sci. 2017;18(1):96. doi: 10.3390/ijms18010096. PubMed PMID: 28067795. PubMed PMCID: PMC5297730.
  18. Konopacka M, Rogoliński J. Thiamine prevents X-ray induction of genetic changes in human lymphocytes in vitro. Acta Biochim Pol. 2004;51(3):839-43. PubMed PMID: 15448744.
  19. Haliwell B. Are polyphenols antioxidants or pro-oxidants? What do we learn from cell culture and in vivostudies? Arch Biochem Biophys. 2008; 476(2):107-12. doi: 10.1016/j.abb.2008.01.028. PubMed PMID: 18284912.
  20. Bonner WM. Low-dose radiation: thresholds, bystander effects, and adaptive responses. Proc Natl Acad Sci U S A. 2003;100(9):4973-5. doi: 10.1073/pnas.1031538100. PubMed PMID: 12704228. PubMed PMCID: PMC154280.
  21. Mettler Jr FA, Huda W, Yoshizumi TT, Mahesh M. Effective doses in radiology and diagnostic nuclear medicine: a catalog. Radiology. 2008;248(1):254-63. doi: 10.1148/radiol.2481071451. PubMed PMID: 18566177.
  22. Bahreyni-Toossi MT, Sankian M, Azimian H, Najafi-Amiri M, et al. In vivo study of interferon-γ, transforming growth factor-β, and interleukin-4 gene expression induced by radioadaptive response. J Cancer Res Ther. 2021;17(2):537-42. doi: 10.4103/jcrt.JCRT_71_19. PubMed PMID: 34121704.
  23. Hamzian N, Afereydoon S, Ghorbani M, Abrisham SMJ, Roozmand Z, et al. Equivalent Dose and Risk of Exposure Induced Cancer Death of Different Organs due to Various Image Techniques of EOS Imaging System. J Biomed Phys Eng. 2021;11(3):289-96. doi: 10.31661/jbpe.v0i0.2012-1242. PubMed PMID: 34189117. PubMed PMCID: PMC8236105.
  24. Nieto G, Ros G, Castillo J. Antioxidant and antimicrobial properties of rosemary (Rosmarinus officinalis, L.): A Review. Medicines (Basel). 2018;5(3):98. doi: 10.3390/medicines5030098. PubMed PMID: 30181448. PubMed PMCID: PMC6165352.
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