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Challenges Associated with Convalescent Plasma Infusion Therapy During Pregnancy, a Case Report | ||
| Women’s Health Bulletin | ||
| مقاله 8، دوره 9، شماره 2 - شماره پیاپی 33، تیر 2022، صفحه 118-121 اصل مقاله (206 K) | ||
| نوع مقاله: Case Report | ||
| شناسه دیجیتال (DOI): 10.30476/whb.2021.93429.1151 | ||
| نویسندگان | ||
| Antonio Mastroianni* 1؛ Sonia Greco1؛ Luciana Chidichimo1؛ Maria Vittoria Mauro2؛ Francesca Greco2؛ Filippo Urso3؛ Valeria Vangeli1 | ||
| 1Infectious and Tropical Diseases Unit, “Annunziata” Hospital, Azienda Ospedaliera di Cosenza, Cosenza, Italy | ||
| 2Microbiology and Virology Unit, “Annunziata” Hospital, Azienda Ospedaliera di Cosenza, Cosenza, Italy | ||
| 3Hospital Pharmacy, “Annunziata” Hospital, Azienda Ospedaliera di Cosenza, Cosenza, Italy | ||
| چکیده | ||
| Introduction: The Covid-19 pandemic has so far been characterized by significant morbidity and a high mortality rate worldwide. People who are frail due to age and / or the presence of comorbidities, including pregnant women, are exposed to a greater risk of developing a very serious disease. However, only recently, certain experimental studies have focused on the role of anti- Covid-19 drugs during pregnancy. Convalescent plasma (CP), derived from the people who recover from Covid-19, can represent an interesting therapeutic option for improving the antiviral immune response, owing to its specific neutralizing content and different immune mediators against SarsCov-2. It can also improve the survival of the patients who are diagnosed with the disease early and treated in the primary stages of the disease. Case Presentation: We reported the case of a pregnant patient safely treated with CP at our hospital and conducted a comprehensive literature search using extensive database for similar case reports published from February 12, 2020 to May 31, 2021. Conclusions: An extensive literature search documented the publication of a limited number of case reports concerning Covid-19 hyperimmune plasma treatment (CPT) during pregnancy. The available results are not homogeneous; however, a very early use of CPT may possibly be effective in pregnancy. The evolution of Covid-19-related pneumonia, due to a reduction in both viremia and the concentration of proinflammatory cytokines, can be positively influenced by CPT, together with the standards of care treatment. | ||
| کلیدواژه‌ها | ||
| COVID-19؛ Plasma؛ Pregnancy؛ Pneumonia | ||
| مراجع | ||
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