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Comprehensive Analysis of the HLA Class I and the HLA class II Alleles in Patients with Takayasu Arteritis: Relationship with Clinical Patterns and Prognosis | ||
| Iranian Journal of Immunology | ||
| دوره 18، شماره 4، اسفند 2021، صفحه 354-365 اصل مقاله (438.59 K) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.22034/iji.2021.88846.1911 | ||
| نویسندگان | ||
| Maja Stojanovic* 1؛ Zorana Andric2؛ Dusan Popadic3؛ Marija Stankovic Stanojevic4؛ Rada Miskovic1؛ Dragana Jovanovic5؛ Aleksandra Peric Popadic1؛ Jasna Bolpacic1؛ Vesna Tomic-Spiric1؛ Sanvila Raskovic1 | ||
| 1Clinic of Allergy and Immunology, Clinical Center of Serbia, Belgrade, Serbia, Faculty of Medicine, University of Belgrade, Belgrade, Serbia. | ||
| 2Tissue Typing Department, Blood Transfusion Institute of Serbia, Belgrade, Serbia. | ||
| 3Institute of Microbiology and Immunology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia. | ||
| 4Department of Pathophysiology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia. | ||
| 5Clinic of Allergy and Immunology Clinical Center of Serbia, Belgrade, Serbia. | ||
| چکیده | ||
| Background: Takayasu arteritis (TA) is a systemic vasculitis, affecting mainly the aorta and its branches. Objective: To analyze the HLA class I and class II alleles in patients with TA and explore their relationship with clinical and demographic characteristics, and potential significance in prognosis. Methods: Twenty-five, unrelated TA patients were genotyped for HLA-A, HLA-B, HLA-C, HLA-DRB1, and the HLA-DQB1 loci. The frequencies of the HLA-A, HLA-B, and the HLA-DRB1 were compared with a control group of 1992, while the HLA-C and the HLA-DQB1 were compared with a group of 159 healthy, unrelated individuals. Results: Among TA patients, 5/25 (20%) were identified as the HLA-B*52 carriers. There was a significant difference in the HLA-B*52 allele frequency in the TA patients (10%) compared with the healthy controls (1.2%). Moreover, presence of the HLA-B*52 was associated with significantly earlier disease onset, more severe clinical presentations, and a poorer response to treatment. The HLA-C*03 was detected in 32% of patients and was present exclusively in those with a clinically mild form of the TA, indicating a putative protective effect. Conclusion: These findings indicate that the HLA-B*52 allele contributes to a higher susceptibility to the TA whereas the HLA-C*03, can be a protective factor in the TA. | ||
| کلیدواژه‌ها | ||
| Biomarkers؛ HLA؛ Immunogenetics؛ Takayasu arteritis؛ Vasculitis | ||
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آمار تعداد مشاهده مقاله: 1,020 تعداد دریافت فایل اصل مقاله: 648 |
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