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Elevated IL-37 Serum Levels in Patients with Transitional Cell Carcinoma of Bladder | ||
| Iranian Journal of Immunology | ||
| دوره 18، شماره 4، اسفند 2021، صفحه 346-353 اصل مقاله (538.04 K) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.22034/iji.2021.92669.2167 | ||
| نویسندگان | ||
| Mohammad Reza Haghshenas1؛ Seyed Reza Hosseini1؛ Mohammad Javad Fattahi1؛ Mahyar Malekzadeh1؛ Ali Ariafar2؛ Abbas Ghaderi* 3 | ||
| 1Shiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. | ||
| 2Urology-Oncology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| 3Shiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| چکیده | ||
| Background: Interleukin-37 (IL-37) is a recently described cytokine that emerges as a natural inhibitor of inflammatory and immune responses. However, IL-37 has not yet been investigated in bladder cancer, and its biological role is unknown. Objective: The purpose of this study was to investigate IL-37 serum levels in patients with bladder cancer and determine whether they were linked to the patients' pathological characteristics. Methods: IL-37 serum levels were measured using a commercial ELISA kit in 60 patients with transitional cell carcinoma (TCC) of the bladder (mean age: 64.55±12.93) and 50 healthy controls (mean age: 62.94±12.69). Non-parametric tests were used for statistical comparisons, and the Cohen's d effect size was calculated to evaluate the practical and clinical significance of the results. Results: Our findings indicated an increasing trend in IL-37 serum levels in patients with TCC (42.77±3.36 pg/ml) in comparison with controls (40.51±7.32 pg/ml, p=0.09). However, IL-37 serum levels were found to be significantly higher in male patients (44.72±3.81 pg/ml) and patients aged ≥70 (46.92±6.77 pg/ml) in comparison with male controls (29.96±3.30 pg/ml, p=0.026) and controls aged ≥70 (23.62±4.43 pg/ml, p=0.009). In comparison to similar controls, Cohen's d effect size for patients aged ≥70 years was found to be 0.90. Conclusion: The findings reveal a higher serum level of IL-37 in patients with TCC, which might be clinically associated with immunosuppression and tumor growth. However, this is a preliminary study, and more research on the biological role of IL-37 and its potential therapeutic effects in bladder cancer is required. | ||
| کلیدواژه‌ها | ||
| Bladder Cancer؛ Interleukin-37 (IL-37)؛ Serum | ||
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آمار تعداد مشاهده مقاله: 1,160 تعداد دریافت فایل اصل مقاله: 762 |
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