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More Evidence of the Link of Interleukin-6 and Interleukin-10 with Critical COVID-19: A Report in Mexican Patients | ||
| Iranian Journal of Immunology | ||
| دوره 18، شماره 4، اسفند 2021، صفحه 331-337 اصل مقاله (463.34 K) | ||
| نوع مقاله: Short Communication | ||
| شناسه دیجیتال (DOI): 10.22034/iji.2021.89905.1978 | ||
| نویسندگان | ||
| German Reynaldo Jiménez-Gastélum1؛ Arely Monserrant Espinoza-Ortega2؛ Rosalío Ramos-Payán3؛ Maribel Aguilar-Medina3؛ Jorge López-Gutiérrez4؛ Carlos Villegas-Mercado5؛ Luis Antonio Ochoa-Ramirez6؛ Horacio Rendón-Aguilar6؛ Juan Fidel Osuna-Ramos7؛ Juan José Ríos-Tostado8؛ Jesús Salvador Velarde-Félix* 9 | ||
| 1Facultad de Biología, Universidad Autónoma de Sinaloa (UAS), Culiacán, Sinaloa, México. | ||
| 2Hospital General de Culiacán, “Bernardo J Gastélum”, Servicios de Salud de Sinaloa, Culiacán, Sinaloa, México | ||
| 3Facultad de Ciencias Químico Biológicas, UAS, Culiacán, Sinaloa, México. | ||
| 4Facultad de Biología, UAS, Culiacán, Sinaloa, México. | ||
| 5Facultad de Odontología, UAS, Culiacán, Sinaloa, México. | ||
| 6Hospital General de Culiacán, “Bernardo J Gastélum”, Servicios de Salud de Sinaloa, Culiacán, Sinaloa, México. | ||
| 7Departamento de Infectómica y Patogénesis Molecular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV-IPN), Ciudad de México, México. | ||
| 8Facultad de Biología, UAS, Culiacán, Sinaloa, México; Hospital General de Culiacán, “Bernardo J Gastélum”, Servicios de Salud de Sinaloa, Culiacán, Sinaloa, México. | ||
| 9Facultad de Biología, UAS; Hospital General de Culiacán, “Bernardo J Gastélum”, Servicios de Salud de Sinaloa, Culiacán, Sinaloa, México. | ||
| چکیده | ||
| Background: According to the World Health Organization, Mexico presents one of the highest mortality rates due to coronavirus disease 2019 (COVID-19). The "cytokine storm" phenomenon has been proposed as a pathological hallmark of severe COVID-19. Objective: To determine the association of serum cytokine levels with COVID-19 severity. Methods: We studied the cytokines IL-2, IL-4, IL-6, IL-10, TNF-α, and the IFN-γ serum levels through flow cytometry in 56 COVID-19 patients (24 critical and 32 non-critical) from Northwest Mexico. Results: We observed a significant increase in the IL-6 and the IL-10 levels in the sera of critical patients. These cytokines were also associated with mechanical ventilation necessity and death, IL-6 showing AUC values above 0.7 for both variables; and correlated with Na+, creatinine, and platelet levels. On the other hand, no association was found between IL-2, IL-4, TNF-α, and IFN-γ with tested variables. Conclusion: Our results corroborate previous observations regarding IL-6 and IL-10 involvement in the severity of COVID-19. | ||
| کلیدواژه‌ها | ||
| COVID-19؛ Cytokine؛ IL-6؛ IL-10؛ Mechanic Ventilation | ||
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