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Upregulation of Interleukin-6 in HPV-Positive Breast Cancer Patients | ||
| Iranian Journal of Immunology | ||
| دوره 18، شماره 4، اسفند 2021، صفحه 315-330 اصل مقاله (1.15 M) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.22034/iji.2021.89107.1930 | ||
| نویسندگان | ||
| Javad Charostad1؛ Azarakhsh Azaran2؛ Mohsen Nakhaei2؛ Akram Astani3؛ Gholam Abbas Kaydani4؛ Azim Motamedfar5؛ manoochehr makvandi* 2 | ||
| 1Cancer Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran, Department of Medical Virology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran | ||
| 2Department of Virology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran | ||
| 3Department of Microbiology, Shahid Sadoghi University of Medical Science, Yazd, Iran | ||
| 4Department of Laboratory Sciences, School of Allied Health Sciences, Ahvaz Jundishapur University of Medical sciences Ahvaz, Iran | ||
| 5Department of Nuclear Medicine, School of Medicine, Golestan Hospital, Ahvaz Jundishapur University of Medical sciences,Ahvaz, Iran | ||
| چکیده | ||
| Background: Interleukin-6 (IL-6) is a well-known proinflammatory cytokine with tumor promoting capacity in various forms of malignancies including breast cancer (BC). Data highlighted the substantial role of HPV in the pathogenesis of BC. Compelling evidence suggests the contribution of HPV in carcinogenesis through triggering inflammatory cytokines such as IL-6. Objective: Here, we assessed the correlation between the presence of HPV infection and the status of IL-6 expression and serum level in BC. Methods: 72 tissue specimens including tumoral (Case; n=36) and their adjacent normal tissues (Control; n=36) were used. Nested-PCR and Real-Time PCR were employed to identify HPV DNA and assess the expression of IL-6, respectively. In addition, 72 sera samples from BC patients (n=36) and an age-matched healthy control group (n=36) were taken to measure the IL-6 serum level by ELISA. Results: Overall, the HPV DNA was detected in 19.4% (14/72) of samples. 33.33% (12/36) of cases and 5.5% (2/36) of the controls were found to be positive for HPV (P=0.003). The overexpression of IL-6 was observed in HPV+ samples compared to HPV- samples (P=0.05). However, the concentration of IL-6 serum level was remarkably different between patients and normal controls (P=0.0001). Intriguingly, IL-6 serum level was connected to the advanced clinical stage (III/IV), high grade (II/III), metastasis and, ER+ status of patients. Conclusions: Our finding indicated that the overexpression of the IL-6 may be connected to HPV infection in BC. Furthermore, the results reinforced the clinical significance and prognostic value of the serum IL-6 in BC patients. | ||
| کلیدواژه‌ها | ||
| Breast Neoplasm؛ Human Papillomavirus؛ Inflammation؛ Interleukin-6 | ||
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آمار تعداد مشاهده مقاله: 1,537 تعداد دریافت فایل اصل مقاله: 1,040 |
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