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NG, Devadath, VL, Ashoka Babu, BV, Basavaraj, Azamthulla, Mohammad. (1400). Floating Microballoons of Rhynchosia densiflora Leaf Extract for the Treatment of Peptic Ulcer. سامانه مدیریت نشریات علمی, 8(1), 25-36. doi: 10.30476/tips.2021.93365.1124
Devadath NG; Ashoka Babu VL; Basavaraj BV; Mohammad Azamthulla. "Floating Microballoons of Rhynchosia densiflora Leaf Extract for the Treatment of Peptic Ulcer". سامانه مدیریت نشریات علمی, 8, 1, 1400, 25-36. doi: 10.30476/tips.2021.93365.1124
NG, Devadath, VL, Ashoka Babu, BV, Basavaraj, Azamthulla, Mohammad. (1400). 'Floating Microballoons of Rhynchosia densiflora Leaf Extract for the Treatment of Peptic Ulcer', سامانه مدیریت نشریات علمی, 8(1), pp. 25-36. doi: 10.30476/tips.2021.93365.1124
NG, Devadath, VL, Ashoka Babu, BV, Basavaraj, Azamthulla, Mohammad. Floating Microballoons of Rhynchosia densiflora Leaf Extract for the Treatment of Peptic Ulcer. سامانه مدیریت نشریات علمی, 1400; 8(1): 25-36. doi: 10.30476/tips.2021.93365.1124

Floating Microballoons of Rhynchosia densiflora Leaf Extract for the Treatment of Peptic Ulcer

Trends in Pharmaceutical Sciences
مقاله 4، دوره 8، شماره 1، خرداد 2022، صفحه 25-36    اصل مقاله (1.17 M)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.30476/tips.2021.93365.1124
نویسندگان
Devadath NG1؛ Ashoka Babu VL2؛ Basavaraj BV3؛ Mohammad Azamthulla* 1
1Department of Pharmacology, Faculty of Pharmacy, M S Ramaiah University of Applied Sciences, Bengaluru-560054, India.
2Department of Pharmacognosy, Faculty of Pharmacy, M S Ramaiah University of Applied Sciences, Bengaluru-560054, India.
3Department of Pharmaceutics, Faculty of Pharmacy, M S Ramaiah University of Applied Sciences, Bengaluru-560054, India.
چکیده
Peptic ulcer is one of the most common gastrointestinal problems diagnosed all over the world. The aim of the present study is to develop floating microballoons of Rhynchosia densiflora (Roth) DC leaf extract and to evaluate its peptic ulcer activity. An ethanolic extract of R. densiflora (Roth) DC leaves was prepared by Soxhlet extraction and subjected to phytochemical analysis. Microballoons loaded with ethanolic extract of R. densiflora leaf were developed by solvent evaporation method and characterized by optical microscopy, floating time, and release characteristics. Acute oral toxicity study of microballons was carried out following OECD guidelines 423 and antiulcer activity was performed by pylorus ligation, indomethacin and cystamine induced duodenal ulcer methods. R. densiflora extract was found to contain glycosides, proteins, flavonoids, phenolic compounds, tannins and saponins. The particle size of microballoons of R. densiflora extract was found to be in the range of 300 μm. Acute toxicity studies of microballoons did not produce any toxic symptoms and mortality in animals, hence 100 and 200 mg/kg concentrations were selected to screen antiulcer activity. Both the doses showed significant gastric ulcer healing effect and gastric antisecretory effect in pylorus ligated rats, gastric cytoprotective effect in indomethacin induced gastric ulcer and also produced a significant reduction in duodenal ulcers. Dose of 200 mg/kg showed highly significant antiulcer activity than 100 mg/kg. Thus, it is concluded that floating microballoons loaded with R. densiflora extract significantly reduced gastric acid secretion, increased healing of gastric ulcers and also prevent the duodenal ulcers in rats.
Please cite this article as: Devadath NG, Ashoka Babu VL, Basavaraj BV, Mohammad Azamthulla. Floating Microballoons for the treatment of Peptic Ulcer. Trends in Pharmaceutical Sciences. 2022;8(1):25-36.
doi: 10.30476/TIPS.2021.93365.1124
کلیدواژه‌ها
Peptic Ulcer؛ Microspheres؛ Rhynchosia densiflora (Roth) DC؛ Pylorus Ligation؛ Gastric acid؛ Antiulcer agents
مراجع
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