LinkedIn

 آمار

تعداد نشریات20
تعداد شماره‌ها1,141
تعداد مقالات10,461
تعداد مشاهده مقاله44,820,643
تعداد دریافت فایل اصل مقاله10,657,159
Omidvari, Shapour, Eskandari, Zahra, Nasrollahi, Hamid, Ahmadloo, Niloofar, Ansari, Mansour, Hamedi, Seyed Hassan, Khanjani, Nezhat, Kadkhodaei, Behnam, Mosalaei, Ahmad, Mohammadianpanah, Mohammad. (1401). The Investigation of Prophylactic Effect of StrataXRT Gel on Radiation-Induced Dermatitis in Breast Cancer Patients: A Randomized Clinical Trial. سامانه مدیریت نشریات علمی, 13(2), 293-298. doi: 10.30476/mejc.2021.86775.1372
Shapour Omidvari; Zahra Eskandari; Hamid Nasrollahi; Niloofar Ahmadloo; Mansour Ansari; Seyed Hassan Hamedi; Nezhat Khanjani; Behnam Kadkhodaei; Ahmad Mosalaei; Mohammad Mohammadianpanah. "The Investigation of Prophylactic Effect of StrataXRT Gel on Radiation-Induced Dermatitis in Breast Cancer Patients: A Randomized Clinical Trial". سامانه مدیریت نشریات علمی, 13, 2, 1401, 293-298. doi: 10.30476/mejc.2021.86775.1372
Omidvari, Shapour, Eskandari, Zahra, Nasrollahi, Hamid, Ahmadloo, Niloofar, Ansari, Mansour, Hamedi, Seyed Hassan, Khanjani, Nezhat, Kadkhodaei, Behnam, Mosalaei, Ahmad, Mohammadianpanah, Mohammad. (1401). 'The Investigation of Prophylactic Effect of StrataXRT Gel on Radiation-Induced Dermatitis in Breast Cancer Patients: A Randomized Clinical Trial', سامانه مدیریت نشریات علمی, 13(2), pp. 293-298. doi: 10.30476/mejc.2021.86775.1372
Omidvari, Shapour, Eskandari, Zahra, Nasrollahi, Hamid, Ahmadloo, Niloofar, Ansari, Mansour, Hamedi, Seyed Hassan, Khanjani, Nezhat, Kadkhodaei, Behnam, Mosalaei, Ahmad, Mohammadianpanah, Mohammad. The Investigation of Prophylactic Effect of StrataXRT Gel on Radiation-Induced Dermatitis in Breast Cancer Patients: A Randomized Clinical Trial. سامانه مدیریت نشریات علمی, 1401; 13(2): 293-298. doi: 10.30476/mejc.2021.86775.1372

The Investigation of Prophylactic Effect of StrataXRT Gel on Radiation-Induced Dermatitis in Breast Cancer Patients: A Randomized Clinical Trial

Middle East Journal of Cancer
مقاله 10، دوره 13، شماره 2 - شماره پیاپی 50، تیر 2022، صفحه 293-298    اصل مقاله (109.55 K)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/mejc.2021.86775.1372
نویسندگان
Shapour Omidvari1؛ Zahra Eskandari2؛ Hamid Nasrollahi* 2؛ Niloofar Ahmadloo1؛ Mansour Ansari1؛ Seyed Hassan Hamedi2؛ Nezhat Khanjani2؛ Behnam Kadkhodaei2؛ Ahmad Mosalaei2؛ Mohammad Mohammadianpanah3
1Breast Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
2Radiation Oncology Department, Shiraz University of Medical Sciences, Shiraz, Iran
3Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Background: Breast cancer is among the most prevalent cancers in women. Radiotherapy is an important part in treatment of breast cancer, associated with some side-effects, including skin dermatitis. Dermatitis may be severe and impair quality of life. Multiple agents have been studied, but no standard treatment is yet available. Silicone based gel (StrataXRT) was promising in some studies in reducing skin inflammation and also radiotherapy-induced dermatitis.
Method: This was a randomized trial on 100 women with breast cancer who had undergone quadrantectomy for breast cancer. They received StrataXRT gel or best supportive care during radiotherapy. Dermatitis area and grade of dermatitis were measured.
Results: Regarding the mean size of radiation-induced dermatitis area, there was a significant difference between the intervention (36.88 cm2 ± 69.93) and control (83.83 cm2 ± 79.34) groups (P = 0.002). During radiotherapy, except in the fourth week, dermatitis was significantly more severe in the control group.
Conclusion: It seems that StrataXRT is helpful in decreasing radiotherapy-induced dermatitis.
کلیدواژه‌ها
Breast neoplasms؛ Radiotherapy؛ Dermatitis
اصل مقاله

How to cite this article:

Omidvari S, Eskandari Z, Nasrollahi H, Ahmadloo N, Ansari M, Hamedi SH, et al. The investigation of prophylactic effect of StrataXRT gel on radiation-induced dermatitis in breast cancer patients: a randomized clinical trial. Middle East J Cancer. 2022;13(2):293-8. doi: 10.30 476/mejc.2021.86775.1372.

مراجع
  1. Geara FB, Eid T, Zouain N, Thebian R, Andraos T, Chehab C, et al. Randomized, prospective, open-label phase III trial comparing mebo ointment with biafine cream for the management of acute dermatitis during radiotherapy for breast cancer. Am J Clin Oncol. 2018;41(12):1257-62. doi: 10.1097/COC.0000000000000460.
  2. Mosalaei A, Nasrolahi H, Shafizad A, Ahmadloo N, Ansari M, Mosleh-Shirazi MA, et al. Effect of oral zinc sulphate in prevention of radiation induced oropharyngeal mucositis during and after radiotherapy in patients with head and neck cancers. Middle East J Cancer. 2010;1(2):69-76.
  3. Ahmadloo N, Kadkhodaei B, Omidvari S, Mosalaei A, Ansari M, Nasrollahi H, et al. Lack of prophylactic effects of aloe vera gel on radiation induced dermatitis in breast cancer patients. Asian Pac J Cancer Prev. 2017;18(4):1139-43. doi:10.22034/APJCP.2017.18.4.1139.
  4. Salvo N, Barnes E, van Draanen J, Stacey E, Mitera G, Breen D, et al. Prophylaxis and management of acute radiation-induced skin reactions: a systematic review of the literature. Curr Oncol. 2010;17(4):94-112. doi: 10.3747/co.v17i4.493.
  5. Chan RJ, Blades R, Jones L, Downer TR, Peet SC, Button E, et al. A single-blind, randomised controlled trial of StrataXRT(R) - A silicone-based film-forming gel dressing for prophylaxis and management of radiation dermatitis in patients with head and neck cancer. Radiother Oncol. 2019;139:72-8. doi:10.1016/j.radonc.2019.07.014.
  6. Ahn S, Sung K, Kim HJ, Choi YE, Lee YK, Kim JS, et al. Reducing radiation dermatitis using a filmforming silicone gel during breast radiotherapy: A pilot randomized-controlled trial. In Vivo. 2020;34(1):413-22. doi: 10.21873/invivo.11790.
  7. Ulff E, Maroti M, Serup J, Nilsson M, Falkmer U. Prophylactic treatment with a potent corticosteroid cream ameliorates radiodermatitis, independent of radiation schedule: A randomized double blinded study. Radiother Oncol. 2017;122(1):50-3. doi:10.1016/j.radonc.2016.11.013.
  8. Pinnix C, Perkins GH, Strom EA, Tereffe W, Woodward W, Oh JL, et al. Topical hyaluronic acid vs. standard of care for the prevention of radiation dermatitis after adjuvant radiotherapy for breast cancer: single-blind randomized phase III clinical trial. Int J Radiat Oncol Biol Phys. 2012;83(4):1089-94. doi:10.1016/j.ijrobp.2011.09.021.
  9. Gu J, Zhu S, Li X, Wu H, Li Y, Hua F. Effect of amifostine in head and neck cancer patients treated with radiotherapy: a systematic review and meta-analysis based on randomized controlled trials. PLoS One. 2014;9(5):e95968. doi: 10.1371/journal.pone.
  10. Wells M, Macmillan M, Raab G, MacBride S, Bell N, MacKinnon K, et al. Does aqueous or sucralfate cream affect the severity of erythematous radiation skin reactions? A randomised controlled trial. Radiother Oncol. 2004;73(2):153-62. doi: 10.1371/journal.
    0095968.
  11. Fisher J, Scott C, Stevens R, Marconi B, Champion L, Freedman GM, et al. Randomized phase III study comparing Best Supportive Care to Biafine as a prophylactic agent for radiation-induced skin toxicity for women undergoing breast irradiation: Radiation
    Therapy Oncology Group (RTOG) 97-13. Int J Radiat Oncol Biol Phys. 2000;48(5):1307-10. doi: 10.1016/s0360-3016(00)00782-3.
آمار
تعداد مشاهده مقاله: 3,932
تعداد دریافت فایل اصل مقاله: 3,269


سامانه مدیریت نشریات علمی. قدرت گرفته از سیناوب