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Elaidy, Noha, Abdelbary, Eman, Hegazy, Mohamed, Elwan, Amira. (1401). Prognostic Significance of PD-L1 and PTEN Expression in Prostatic Cancer. سامانه مدیریت نشریات علمی, 13(2), 247-254. doi: 10.30476/mejc.2021.87068.1393
Noha F. Elaidy; Eman H. Abdelbary; Mohamed W. Hegazy; Amira Elwan. "Prognostic Significance of PD-L1 and PTEN Expression in Prostatic Cancer". سامانه مدیریت نشریات علمی, 13, 2, 1401, 247-254. doi: 10.30476/mejc.2021.87068.1393
Elaidy, Noha, Abdelbary, Eman, Hegazy, Mohamed, Elwan, Amira. (1401). 'Prognostic Significance of PD-L1 and PTEN Expression in Prostatic Cancer', سامانه مدیریت نشریات علمی, 13(2), pp. 247-254. doi: 10.30476/mejc.2021.87068.1393
Elaidy, Noha, Abdelbary, Eman, Hegazy, Mohamed, Elwan, Amira. Prognostic Significance of PD-L1 and PTEN Expression in Prostatic Cancer. سامانه مدیریت نشریات علمی, 1401; 13(2): 247-254. doi: 10.30476/mejc.2021.87068.1393

Prognostic Significance of PD-L1 and PTEN Expression in Prostatic Cancer

Middle East Journal of Cancer
مقاله 5، دوره 13، شماره 2 - شماره پیاپی 50، تیر 2022، صفحه 247-254    اصل مقاله (2.92 M)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/mejc.2021.87068.1393
نویسندگان
Noha F. Elaidy1؛ Eman H. Abdelbary1؛ Mohamed W. Hegazy* 2؛ Amira Elwan2
1Department of Pathology, School of Medicine, Zagazig University, Zagazig, Egypt
2Department of Clinical Oncology and Nuclear Medicine, School of Medicine, Zagazig University, Zagazig, Egypt
چکیده
Background: Programmed death- ligand 1(PD-L1) acts as an immune checkpoint inhibitor. Phosphatase and tensin homolog (PTEN) is a somatically mutated tumor suppressor gene in numerous types of human cancer. The current study aimed to assess the prognostic value of PD-L1 and PTEN expression in prostatic cancer patients, as well as their relationship with the clinicopathological features of the disease.
Method: A total of 55 needle biopsy specimens were retrospectively diagnosed as prostatic adenocarcinoma. Immunohistochemical staining with PD-L1 and PTEN were evaluated in all the cases. The patients were followed up for 5 years in order to detect disease recurrence and survival.
Results: PD-L1 expression in Prostate cancer was positively correlated with high prostatic specific antigen (PSA), higher Gleason score, advanced stage, higher tumor relapse, and worse disease-free and overall survival (P < 0.001). PTEN loss was significantly associated with high PSA, higher Gleason score < 7, advanced tumor stage, tumor relapse, and worse disease-free and overall survival (P < 0.001). We observed a significant negative correlation between PTEN and PD-L1.
Conclusion: PDL-1 and PTEN are prognostic markers for prostate cancer, which can differentiate between the patients who are at a high risk of disease progression and may successively provide novel targeted therapies.
کلیدواژه‌ها
Prostatic neoplasms؛ PD-L1؛ PTEN؛ Immunohistochemistry؛ Prognosis
اصل مقاله

How to cite this article:

Elaidy NF, Abdelbary EH, Hegazy MW, Elwan A. Prognostic significance of PD-L1 and PTEN expression in prostatic cancer. Middle East J Cancer. 2 0 2 2 ; 1 3 ( 2 ) : 2 4 7 - 5 4 . doi:10.30476/mejc.2021.87068. 1393.

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