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Shahidi, Mohsen, Rahmani, Khaled, Afkhamzadeh, Abdorrahim. (1401). Association of Abnormal Serum L-Carnitine Levels with Idiopathic Changes in Left Ventricular Geometry in Pediatric and Adolescent Patients. سامانه مدیریت نشریات علمی, 47(3), 256-263. doi: 10.30476/ijms.2021.88464.1919
Mohsen Shahidi; Khaled Rahmani; Abdorrahim Afkhamzadeh. "Association of Abnormal Serum L-Carnitine Levels with Idiopathic Changes in Left Ventricular Geometry in Pediatric and Adolescent Patients". سامانه مدیریت نشریات علمی, 47, 3, 1401, 256-263. doi: 10.30476/ijms.2021.88464.1919
Shahidi, Mohsen, Rahmani, Khaled, Afkhamzadeh, Abdorrahim. (1401). 'Association of Abnormal Serum L-Carnitine Levels with Idiopathic Changes in Left Ventricular Geometry in Pediatric and Adolescent Patients', سامانه مدیریت نشریات علمی, 47(3), pp. 256-263. doi: 10.30476/ijms.2021.88464.1919
Shahidi, Mohsen, Rahmani, Khaled, Afkhamzadeh, Abdorrahim. Association of Abnormal Serum L-Carnitine Levels with Idiopathic Changes in Left Ventricular Geometry in Pediatric and Adolescent Patients. سامانه مدیریت نشریات علمی, 1401; 47(3): 256-263. doi: 10.30476/ijms.2021.88464.1919

Association of Abnormal Serum L-Carnitine Levels with Idiopathic Changes in Left Ventricular Geometry in Pediatric and Adolescent Patients

Iranian Journal of Medical Sciences
مقاله 9، دوره 47، شماره 3، مرداد 2022، صفحه 256-263    اصل مقاله (288.86 K)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/ijms.2021.88464.1919
نویسندگان
Mohsen Shahidi1؛ Khaled Rahmani2؛ Abdorrahim Afkhamzadeh* 3
1Department of Pediatric Cardiology, Rajaiee Heart Center, Tehran, Iran
2Liver and Digestive Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran
3Social Determinants of Health Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran
چکیده
Background: There is no compelling evidence to prove an association between serum free L-carnitine levels and changes in left ventricular (LV) geometry. The present study aimed to evaluate a possible association between these parameters.
Methods: In a cross-sectional study, 504 outpatients were randomly selected among those registered at Sanandaj Pediatric Heart Clinic (Sanandaj, Iran) during 2014-2020. The patients aged one to 25 years and were presented with cardiac complaints. The serum L-carnitine levels of all patients were evaluated and associated with changes in LV geometry measured by echocardiography. The association was assessed using the Chi squared test, Fisher’s exact test, and one-way ANOVA with post hoc Tukey test. Data were analyzed using SPSS software (version 22.0). P≤0.05 was considered statistically significant.
Results: The mean serum L-carnitine levels in the normal, low, and high serum groups were 52.69, 14.16, and 178.67 nmol/dL, respectively. There was a significant statistical association between abnormal serum levels of free L-carnitine and changes in LV geometry (p <0.001).
Conclusion: Our findings are indicative of an association between abnormal serum L-carnitine levels and changes in LV geometry in pediatric and adolescent patients.
کلیدواژه‌ها
Heart؛ Carnitine؛ Pediatrics؛ Heart ventricles
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