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Sedaghat, Bafrin, Abbasi, Saeed, Farsaei, Shadi. (1400). Identifying the pattern and risk factors for potential medication dosing errors in chronic renal impairment of critically ill patients. سامانه مدیریت نشریات علمی, 7(4), 279-288. doi: 10.30476/tips.2021.93228.1122
Bafrin Sedaghat; Saeed Abbasi; Shadi Farsaei. "Identifying the pattern and risk factors for potential medication dosing errors in chronic renal impairment of critically ill patients". سامانه مدیریت نشریات علمی, 7, 4, 1400, 279-288. doi: 10.30476/tips.2021.93228.1122
Sedaghat, Bafrin, Abbasi, Saeed, Farsaei, Shadi. (1400). 'Identifying the pattern and risk factors for potential medication dosing errors in chronic renal impairment of critically ill patients', سامانه مدیریت نشریات علمی, 7(4), pp. 279-288. doi: 10.30476/tips.2021.93228.1122
Sedaghat, Bafrin, Abbasi, Saeed, Farsaei, Shadi. Identifying the pattern and risk factors for potential medication dosing errors in chronic renal impairment of critically ill patients. سامانه مدیریت نشریات علمی, 1400; 7(4): 279-288. doi: 10.30476/tips.2021.93228.1122

Identifying the pattern and risk factors for potential medication dosing errors in chronic renal impairment of critically ill patients

Trends in Pharmaceutical Sciences
مقاله 7، دوره 7، شماره 4، اسفند 2021، صفحه 279-288    اصل مقاله (446.89 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.30476/tips.2021.93228.1122
نویسندگان
Bafrin Sedaghat1؛ Saeed Abbasi2، 3، 4؛ Shadi Farsaei* 1
1Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran
2Anesthesiology and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
3Nosocomial Infection Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
4Anesthesiology and Critical Care Department, Isfahan University of Medical Sciences, Isfahan, Iran
چکیده
Purpose: Different prescription entries usually complicate the drug therapy for critically ill patients; therefore, we conducted this prospective study to assess the rates for appropriate renal dosing modifications in chronic kidney disease (CKD) patients admitted to the ICU and reported possible related factors of misadjustments.
Design: We enrolled adult ICU patients who received at least one drug and experienced CKD with the estimated glomerular filtration rate (eGFR) ≤ of 59 ml/min on ICU admission. The latest Lexicomp drug information handbook recommendations were also applied as a standard guide for renal dosing changes.
results: A total of 701 prescription entries were studied in 97 patients, and 13.8% (97 medications) required renal dose adjustment. Of the 97 drugs, 20.6% (20) had not been prescribed appropriately, according to eGFR. Antibiotics were the most likely medication group to require a dose adjustment and comprised the largest number of inappropriate prescriptions in our study. EGFR and the number of drugs that needed dose modification significantly affected renal dosing adjustment accuracy (p = 0.03 and 0.01, respectively).
conclusion: These results revealed a high percentage of appropriate renal dose adjustment in ICU compared to other studies that evaluated non-critically ill patients. However, more attention should be paid to patients with a higher number of prescribed medicines for renal dose modification and lower eGFR to reduce medication errors.
کلیدواژه‌ها
Inappropriate prescribing؛ critical illness؛ renal insufficiency
مراجع
1. Saad R, Hallit S, Chahine B. Evaluation of renal drug dosing adjustment in chronic kidney disease patients at two university hospitals in Lebanon. Pharm Pract (Granada). 2019 Jan-Mar;17(1):1304. doi: 10.18549/PharmPract.2019.1.1304. Epub 2019 Feb 27. PMID: 31015868; PMCID: PMC6463404.
2. Garedow AW, Mulisa Bobasa E, Desalegn Wolide A, Kerga Dibaba F, Gashe Fufa F, Idilu Tufa B, et al. Drug-Related Problems and Associated Factors among Patients Admitted with Chronic Kidney Disease at Jimma University Medical Center, Jimma Zone, Jimma, Southwest Ethiopia: A Hospital-Based Prospective Observational Study. Int J Nephrol. 2019;2019:1504371.
3. Dörks M, Allers K, Schmiemann G, Herget-Rosenthal S, Hoffmann F. Inappropriate Medication in Non-Hospitalized Patients With Renal Insufficiency: A Systematic Review. J Am Geriatr Soc. 2017 Apr;65(4):853-862. doi: 10.1111/jgs.14809. Epub 2017 Feb 27. PMID: 28240771.
4. O'Shaughnessy M, Allen N, O'Regan J, Payne-Danson E, Mentre L, Davin D, Lavin P, Grimes T. Agreement between renal prescribing references and determination of prescribing appropriateness in hospitalized patients with chronic kidney disease. QJM. 2017 Oct 1;110(10):623-628. doi: 10.1093/qjmed/hcx086. PMID: 28431157; PMCID: PMC6256938.
5. Al-Dorzi HM, Eissa AT, Khan RM, Harbi SAA, Aldabbagh T, Arabi YM. Dosing errors of empirical antibiotics in critically ill patients with severe sepsis or septic shock: A prospective observational study. Int J Health Sci (Qassim). 2019 Jul-Aug;13(4):48-55. PMID: 31341455; PMCID: PMC6619455.
6. Boucher BA, Wood GC, Swanson JM. Pharmacokinetic changes in critical illness. Crit Care Clin. 2006 Apr;22(2):255-71, vi. doi: 10.1016/j.ccc.2006.02.011. PMID: 16677999.
7. Crass RL, Rodvold KA, Mueller BA, Pai MP. Renal Dosing of Antibiotics: Are We Jumping the Gun? Clin Infect Dis. 2019 Apr 24;68(9):1596-1602. doi: 10.1093/cid/ciy790. PMID: 30219824.
8. Adebisi SA. Routine reporting of estimated glomerular filtration rate (eGFR) in African laboratories and the need for its increased utilisation in clinical practice. Niger Postgrad Med J. 2013 Mar;20(1):57-62. PMID: 23661212.
9. Saleem A, Masood I. Pattern and Predictors of Medication Dosing Errors in Chronic Kidney Disease Patients in Pakistan: A Single Center Retrospective Analysis. PLoS One. 2016 Jul 1;11(7):e0158677. doi: 10.1371/journal.pone.0158677. PMID: 27367594; PMCID: PMC4930166.
10. Cartet-Farnier E, Goutelle-Audibert L, Maire P, De la Gastine B, Goutelle S. Implications of using the MDRD or CKD-EPI equation instead of the Cockcroft-Gault equation for estimating renal function and drug dosage adjustment in elderly patients. Fundam Clin Pharmacol. 2017 Feb;31(1):110-119. doi: 10.1111/fcp.12241. Epub 2016 Oct 5. PMID: 27599753.
11. Nyman HA, Dowling TC, Hudson JQ, Peter WL, Joy MS, Nolin TD. Comparative evaluation of the Cockcroft-Gault Equation and the Modification of Diet in Renal Disease (MDRD) study equation for drug dosing: an opinion of the Nephrology Practice and Research Network of the American College of Clinical Pharmacy. Pharmacotherapy. 2011 Nov;31(11):1130-44. doi: 10.1592/phco.31.11.1130. PMID: 22026399.
12. Roberts JA, Kumar A, Lipman J. Right Dose, Right Now: Customized Drug Dosing in the Critically Ill. Crit Care Med. 2017 Feb;45(2):331-336. doi: 10.1097/CCM.0000000000002210. PMID: 28098629.
13. Getachew H, Tadesse Y, Shibeshi W. Drug dosage adjustment in hospitalized patients with renal impairment at Tikur Anbessa specialized hospital, Addis Ababa, Ethiopia. BMC Nephrol. 2015 Oct 7;16:158. doi: 10.1186/s12882-015-0155-9. PMID: 26446847; PMCID: PMC4597768.
14. Decloedt E, Leisegang R, Blockman M, Cohen K. Dosage adjustment in medical patients with renal impairment at Groote Schuur Hospital. S Afr Med J. 2010 May 4;100(5):304-6. doi: 10.7196/samj.3955. PMID: 20460024.
15. Sweileh WM, Janem SA, Sawalha AF, Abu-Taha AS, Zyoud SH, Sabri IA, Al-Jabi SW, Jaradat NA, Zaid AA. Medication dosing errors in hospitalized patients with renal impairment: a study in Palestine. Pharmacoepidemiol Drug Saf. 2007 Aug;16(8):908-12. doi: 10.1002/pds.1412. PMID: 17464934.
16. Pillans PI, Landsberg PG, Fleming AM, Fanning M, Sturtevant JM. Evaluation of dosage adjustment in patients with renal impairment. Intern Med J. 2003 Jan-Feb;33(1-2):10-3. doi: 10.1046/j.1445-5994.2003.00330.x. Erratum in: Intern Med J. 2003 Jul;33(7):331. PMID: 12534872.
17. Altunbas G, Yazc M, Solak Y, Gul EE, Kayrak M, Kaya Z, et al. Renal Drug Dosage Adjustment According to Estimated Creatinine Clearance in Hospitalized Patients With Heart Failure. Am J Ther. 2016 Jul-Aug;23(4):e1004-8. doi: 10.1097/01.mjt.0000434042.62372.49. PMID: 24263162.
18. Hanlon JT, Wang X, Handler SM, Weisbord S, Pugh MJ, Semla T, et al. Potentially inappropriate prescribing of primarily renally cleared medications for older veterans affairs nursing home patients. J Am Med Dir Assoc. 2011 Jun;12(5):377-83. doi: 10.1016/j.jamda.2010.04.008. Epub 2010 Oct 2. PMID: 21450179; PMCID: PMC3102140.
19. van Dijk EA, Drabbe NR, Kruijtbosch M, De Smet PA. Drug dosage adjustments according to renal function at hospital discharge. Ann Pharmacother. 2006 Jul-Aug;40(7-8):1254-60. doi: 10.1345/aph.1G742. Epub 2006 Jun 27. PMID: 16804098.
20. Khanal A, Peterson GM, Castelino RL, Jose MD. Potentially inappropriate prescribing of renally cleared drugs in elderly patients in community and aged care settings. Drugs Aging. 2015 May;32(5):391-400. doi: 10.1007/s40266-015-0261-1. PMID: 25925940.
21. Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron. 1976;16(1):31-41. doi: 10.1159/000180580. PMID: 1244564.
22. Levey AS, Bosch JP, Lewis JB, Greene T, Rogers N, Roth D. A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group. Ann Intern Med. 1999 Mar 16;130(6):461-70. doi: 10.7326/0003-4819-130-6-199903160-00002. PMID: 10075613.
23. Drug information handbook : a comprehensive resource for all clinicians and healthcare professionals. 29nd ed: Hudson, Ohio : Lexi-Comp; 2021.
24. Prajapati A, Ganguly B. Appropriateness of drug dose and frequency in patients with renal dysfunction in a tertiary care hospital: A cross-sectional study. J Pharm Bioallied Sci. 2013 Apr;5(2):136-40. doi: 10.4103/0975-7406.111829. PMID: 23833519; PMCID: PMC3697192.
25. Alahdal AM, Elberry AA. Evaluation of applying drug dose adjustment by physicians in patients with renal impairment. Saudi Pharm J. 2012 Jul;20(3):217-20. doi: 10.1016/j.jsps.2011.12.005. Epub 2011 Dec 24. PMID: 23960796; PMCID: PMC3745053.
26. Markota NP, Markota I, Tomic M, Zelenika A. Inappropriate drug dosage adjustments in patients with renal impairment. J Nephrol. 2009 Jul-Aug;22(4):497-501. PMID: 19662605.
27. Sah SK, Wanakamanee U, Lerkiatbundit S, Regmi BM. Drug dosage adjustment of patients with impaired renal function at hospital discharge in a teaching hospital. J Nepal Health Res Counc. 2014 Jan;12(26):54-8. PMID: 25574986.
28. Salomon L, Deray G, Jaudon MC, Chebassier C, Bossi P, Launay-Vacher V, Diquet B, Ceza JM, Levu S, Brücker G, Ravaud P. Medication misuse in hospitalized patients with renal impairment. Int J Qual Health Care. 2003 Aug;15(4):331-5. doi: 10.1093/intqhc/mzg046. PMID: 12930048.
29. Tong EY, Edwards G, Hua PU, Yip G. Systematic review of clinical outcomes of clinical pharmacist roles in hospitalised general medicine patients. J Pharm Pract Res. 2020;50(4):297-307.
30. Camargo MS, Mistro S, Oliveira MG, Passos LCS. Association between increased mortality rate and antibiotic dose adjustment in intensive care unit patients with renal impairment. Eur J Clin Pharmacol. 2019 Jan;75(1):119-126. doi: 10.1007/s00228-018-2565-7. Epub 2018 Oct 1. PMID: 30276417.
31. Bhardwaja B, Carroll NM, Raebel MA, Chester EA, Korner EJ, Rocho BE, et al. Improving prescribing safety in patients with renal insufficiency in the ambulatory setting: the Drug Renal Alert Pharmacy (DRAP) program. Pharmacotherapy. 2011 Apr;31(4):346-56. doi: 10.1592/phco.31.4.346. PMID: 21449624.
32. Sellier E, Colombet I, Sabatier B, Breton G, Nies J, Zapletal E, Arlet JB, Somme D, Durieux P. Effect of alerts for drug dosage adjustment in inpatients with renal insufficiency. J Am Med Inform Assoc. 2009 Mar-Apr;16(2):203-10. doi: 10.1197/jamia.M2805. Epub 2008 Dec 11. PMID: 19074305; PMCID: PMC2649320.

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