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Tabaei, Banafsheh Sadat, Mousavi, Seyedeh Neda, Rahimian, Aliasghar, Rostamkhani, Hadi, Mellati, Ali Awsat, Jameshorani, Maryam. (1400). Co-Administration of Vitamin E and Atorvastatin Improves Insulin Sensitivity and Peroxisome Proliferator-Activated Receptor-γ Expression in Type 2 Diabetic Patients: A Randomized Double-Blind Clinical Trial. سامانه مدیریت نشریات علمی, 47(2), 114-122. doi: 10.30476/ijms.2021.89102.1981
Banafsheh Sadat Tabaei; Seyedeh Neda Mousavi; Aliasghar Rahimian; Hadi Rostamkhani; Ali Awsat Mellati; Maryam Jameshorani. "Co-Administration of Vitamin E and Atorvastatin Improves Insulin Sensitivity and Peroxisome Proliferator-Activated Receptor-γ Expression in Type 2 Diabetic Patients: A Randomized Double-Blind Clinical Trial". سامانه مدیریت نشریات علمی, 47, 2, 1400, 114-122. doi: 10.30476/ijms.2021.89102.1981
Tabaei, Banafsheh Sadat, Mousavi, Seyedeh Neda, Rahimian, Aliasghar, Rostamkhani, Hadi, Mellati, Ali Awsat, Jameshorani, Maryam. (1400). 'Co-Administration of Vitamin E and Atorvastatin Improves Insulin Sensitivity and Peroxisome Proliferator-Activated Receptor-γ Expression in Type 2 Diabetic Patients: A Randomized Double-Blind Clinical Trial', سامانه مدیریت نشریات علمی, 47(2), pp. 114-122. doi: 10.30476/ijms.2021.89102.1981
Tabaei, Banafsheh Sadat, Mousavi, Seyedeh Neda, Rahimian, Aliasghar, Rostamkhani, Hadi, Mellati, Ali Awsat, Jameshorani, Maryam. Co-Administration of Vitamin E and Atorvastatin Improves Insulin Sensitivity and Peroxisome Proliferator-Activated Receptor-γ Expression in Type 2 Diabetic Patients: A Randomized Double-Blind Clinical Trial. سامانه مدیریت نشریات علمی, 1400; 47(2): 114-122. doi: 10.30476/ijms.2021.89102.1981

Co-Administration of Vitamin E and Atorvastatin Improves Insulin Sensitivity and Peroxisome Proliferator-Activated Receptor-γ Expression in Type 2 Diabetic Patients: A Randomized Double-Blind Clinical Trial

Iranian Journal of Medical Sciences
مقاله 6، دوره 47، شماره 2، خرداد 2022، صفحه 114-122    اصل مقاله (405.39 K)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/ijms.2021.89102.1981
نویسندگان
Banafsheh Sadat Tabaei1، 2؛ Seyedeh Neda Mousavi* 1، 3؛ Aliasghar Rahimian4؛ Hadi Rostamkhani2؛ Ali Awsat Mellati* 1، 2؛ Maryam Jameshorani1
1Zanjan Metabolic Diseases Research Center, Zanjan University of Medical Sciences, Zanjan, Iran
2Department of Clinical Biochemistry, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
3Department of Nutrition, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
4Department of Clinical Biochemistry, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
چکیده
Background: Negative effects of statins on glucose metabolism have been reported. The present study aimed to investigate the effects of co-administration of vitamin E and atorvastatin on glycemic control in hyperlipidemic patients with type 2 diabetes mellitus (T2DM).
Methods: A randomized double-blind clinical trial was conducted at Vali-e-Asr Teaching Hospital (Zanjan, Iran) from July 2017 to March 2018. A total of 30 T2DM female patients were allocated to two groups, namely atorvastatin with placebo (n=15) and atorvastatin with vitamin E (n=15). The patients received daily 20 mg atorvastatin and 400 IU vitamin E or placebo for 12 weeks. Anthropometric and biochemical measures were recorded pre- and post-intervention. Peroxisome proliferator-activated receptor-γ (PPAR-γ) expression was measured in peripheral blood mononuclear cells (PBMCs). Independent sample t test and paired t test were used to analyze between- and within-group variables, respectively. The analysis of covariance (ANCOVA) was used to adjust the effect of baseline variables on the outcomes. p Results: After baseline adjustment, there was a significant improvement in homeostatic model assessment for insulin resistance (HOMA-IR) (P=0.04) and serum insulin (p <0.001) in the atorvastatin with vitamin E group compared to the atorvastatin with the placebo group. In addition, co-administration of vitamin E with atorvastatin significantly upregulated PPAR-γ expression (OR=5.4, P=0.04) in the PBMCs of T2DM patients.
Conclusion: Co-administration of vitamin E and atorvastatin reduced insulin resistance and improved PPAR-γ mRNA expression. Further studies are required to substantiate our findings.
Trial registration number: IRCT 20170918036256N1
کلیدواژه‌ها
Atorvastatin؛ Diabetes mellitus؛ Insulin resistance؛ Peroxisome proliferator-activated receptors؛ Vitamin E
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