LinkedIn

 آمار

تعداد نشریات20
تعداد شماره‌ها1,149
تعداد مقالات10,518
تعداد مشاهده مقاله45,415,503
تعداد دریافت فایل اصل مقاله11,291,298
Hasanzadeh, Malihe, Homaee Shandiz, Fatemeh, Izadpanahee, Nooshin, Mottaghi, Mansoureh. (1400). Is There a Role for Surgery in the Management of Gestational Trophoblastic Neoplasia?. سامانه مدیریت نشریات علمی, 13(1), 128-134. doi: 10.30476/mejc.2021.85287.1269
Malihe Hasanzadeh; Fatemeh Homaee Shandiz; Nooshin Izadpanahee; Mansoureh Mottaghi. "Is There a Role for Surgery in the Management of Gestational Trophoblastic Neoplasia?". سامانه مدیریت نشریات علمی, 13, 1, 1400, 128-134. doi: 10.30476/mejc.2021.85287.1269
Hasanzadeh, Malihe, Homaee Shandiz, Fatemeh, Izadpanahee, Nooshin, Mottaghi, Mansoureh. (1400). 'Is There a Role for Surgery in the Management of Gestational Trophoblastic Neoplasia?', سامانه مدیریت نشریات علمی, 13(1), pp. 128-134. doi: 10.30476/mejc.2021.85287.1269
Hasanzadeh, Malihe, Homaee Shandiz, Fatemeh, Izadpanahee, Nooshin, Mottaghi, Mansoureh. Is There a Role for Surgery in the Management of Gestational Trophoblastic Neoplasia?. سامانه مدیریت نشریات علمی, 1400; 13(1): 128-134. doi: 10.30476/mejc.2021.85287.1269

Is There a Role for Surgery in the Management of Gestational Trophoblastic Neoplasia?

Middle East Journal of Cancer
مقاله 14، دوره 13، شماره 1 - شماره پیاپی 49، فروردین 2022، صفحه 128-134    اصل مقاله (130.54 K)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/mejc.2021.85287.1269
نویسندگان
Malihe Hasanzadeh1؛ Fatemeh Homaee Shandiz* 2؛ Nooshin Izadpanahee3؛ Mansoureh Mottaghi4
1Department of Obstetrics and Gynecology, Women’s Health Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
2Department of Radiotherapy, Women’s Health Research Center, Faculty of Medicine, Mashhad University of Medical sciences, Mashhad, Iran
3Faculty of Medicine, Mashhad University of Medical sciences, Mashhad, Iran
4Department of Obstetrics and Gynecology, Faculty of Medicine, Mashhad University of Medical sciences, Mashhad, Iran
چکیده
Background: Gestational trophoblastic diseases are treated with chemotherapy, but some patients are resistant to it and require surgeries. The role of surgery in the management of these patients is not clearly defined. This study aimed to evaluate the role of surgery in the management of patients with gestational trophoblastic neoplasia (GTN).
Method: This cohort study was performed on patients with GTN referred during June 2009 to June 2019. The patients receiving hysterectomy, hysterotomy to remove uterine lesion, pulmonary lobectomy, craniotomy, and other surgical procedures were included in the study. The surgery indications were resistant to chemotherapy or hemorrhage.
Results: The survival rate of the 31 patients that entered the study was 100%. The mean age of patients was 36 years. The frequency of surgeries were as follow: hysterectomy in 21 patients (67.7%), hysterotomy in six patients (19.4%), removal of lung lesion in three patients (9.7%), and craniotomy in one patient (3.2%). Among the patients, 22 showed complete response to treatment and nine patients had relative response. The relation between response to surgery with variables, such as the type of previous pregnancy, disease pathology, the scoring of disease in World Health Organization (WHO) system, the severity of disease based on The International Federation of Gynecology and Obstetrics (FIGO) stage, and the need to chemotherapy sessions, were significant.
Conclusion: Surgery played an important role in the management of patients with GTD. Previous non-molar pregnancy, stage, and WHO score based on clinical factors affected the response rate of treatment.
کلیدواژه‌ها
Gestational trophoblastic disease؛ Choriocarcinoma؛ Invasive surgery؛ Trophoblastic neoplasms؛ Surgery
اصل مقاله

How to cite this article:

Hasanzadeh M, Homaee Shandiz F, Izadpanahee N, Mottaghi M. Is there a role for surgery in the management of gestational trophoblastic neoplasia? Middle East J Cancer. 2022;13(1):128-34. doi: 10.30476/mejc.2021.85287.1269.

مراجع
1. Kulhan G, Kulhan M, Nayki UA, Nayki C, Ata N, Ulug P, et al. The role of hysterectomy in the treatment of gestational trophoblasticneoplasms: a single center experience. Arch Med Sci Civil Dis. 2017; 2: e37-40. doi: 10.5114/amscd.2017.66527.
2. Staples JN, Podwika S, Duska L. The role of pulmonary resection in the management of metastatic gestational trophoblastic neoplasia: Two cases of durable remission following surgery for chemo-resistant disease. Gynecol Oncol Rep. 2019;30:100496. doi: 10.1016/j.gore.2019. 100496.
3. Eoh KJ, Chung YS, Yim GW, Nam EJ, Kim S, Kim SW, et al. Role of surgical therapy in the management of gestational trophoblastic neoplasia. Obstet Gynecol Sci. 2015;58(4):277-83. doi: 10.5468/ogs.2015. 58.4.277.
4. Doumplis D, Al-Khatib K, Sieunarine K, Lindsay I, Seckl M, Bridges J, et al. A review of the management by hysterectomy of 25 cases of gestational trophoblastic tumours from March 1993 to January 2006. BJOG. 2007;114(9):1168-71. doi: 10.1111/j.1471-0528.2007. 01347.x.
5. Tjalma WA, Vermorken JB. The role of hysterotomy in the management of gestational trophoblastic neoplasia. Int J Gynecol Cancer. 2006;16(2):882-3. doi: 10.1111/j.1525-1438.2006.00585.x.
6. Zhang Y, Xiang Y, Ren T, Wan XR, Yang XY. Study on the indication of surgical resection of pulmonary metastasis of malignant trophoblastic tumor. Zhonghua Fu Chan Ke Za Zhi. 2005;40:83-6. doi: 10.3760/j.issn:0529-567x.2005.02.004.
7. Sum YY, Sim WW, Yu KL, Melee T, Voon PJ. Role of hysterectomy in chemoresistant gestational trophoblastic neoplasia. Med J Malaysia. 2018;73(5): 332-3.
8. Eysbouts YK, Massuger LFAG, IntHout J, Lok CAR, Sweep FCGJ, Ottevanger PB. The added value of hysterectomy in the management of gestational trophoblastic neoplasia. Gynecol Oncol. 2017;145(3): 536-42. doi: 10.1016/j.ygyno.2017.03.018.
9. Feng F, Xiang Y. Surgical management of chemotherapy-resistant gestational trophoblastic neoplasia. Expert Rev Anticancer Ther. 2010; 10(1):71-80. doi: 10.1586/era.09.169.
10. Pires LV, Uberti EM, Fajardo Mdo C, da Cunha AG, Rosa MW, Ayub AC, et al. Role of hysterectomy in the management of patients with gestational trophoblastic neoplasia: importance of receiving treatment in reference centers. J Reprod Med. 2012; 57(7-8):359-68.
11. Feng F, Hu H, Wu L, Ren T, Wan X, Xiang Y. Thoracotomy in refractory gestational trophoblastic neoplasia with lung metastasis after normalization of serum beta human chorionic gonadotropin (β-hCG) with salvage chemotherapy. Onco Targets Ther. 2014;7:171-6. doi: 10.2147/OTT.S56361.
12. Biljana Lazović, Vera Milenković. Treatment of gestational trophoblastic diseases- review of literature. Acta Medica Medianae. 2010;49(1):64-9.
13. Feng F, Xiang Y, Li L, Wan X, Yang X. Clinical parameters predicting therapeutic response to surgical management in patients with chemotherapy-resistant gestational trophoblastic neoplasia. Gynecol Oncol. 2009;113(3):312-5.doi: 10.1016/j.ygyno. 2009.02.025.
14. Ghaemmaghami F, Ashrafgangooei T, Gillani MM, Mosavi A, Behtash N. Major surgeries performed for gestational trophoblastic neoplasms in a teaching hospital in Tehran, Iran. J Gynecol Oncol. 2011;22(2):97-102. doi: 10.3802/jgo.2011.22.2.97.
15. Pongsaranantakul S, Kietpeerakool C. Hysterectomy in gestational trophoblastic neoplasia: Chiang Mai University Hospital's experience. Asian Pac J Cancer Prev. 2009;10(2):311-4.
16. Estrella JL, Soriano-Estrella AL. Conservative management of uterine rupture in gestational trophoblastic neoplasia: a report of 2 cases. Int J Gynecol Cancer. 2009;19(9):1666-70. doi: 10.1111/ IGC.0b013e3181a84252.
17. Hasanzadeh M, Vahid Roodsari F, Ahmadi S, Gavedan Mehr M, Azadeh T. Fertility sparing surgery in gestational trophoblastic neoplasia: A report of 4 cases. Int J Reprod Biomed. 2016;14(9):603-6.

آمار
تعداد مشاهده مقاله: 2,530
تعداد دریافت فایل اصل مقاله: 2,841


سامانه مدیریت نشریات علمی. قدرت گرفته از سیناوب