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Bevelacqua, Joseph John, Mortazavi, Seyed Alireza, Welsh, James S, Mortazavi, Seyed Mohammad Javad. (1402). How Reactivation of SARS-CoV-2 in Astronauts with Dysregulated Immune Systems Can Negatively Affect the Odds of Success in Future Space Missions. سامانه مدیریت نشریات علمی, 13(3), 297-298. doi: 10.31661/jbpe.v0i0.2104-1321
Joseph John Bevelacqua; Seyed Alireza Mortazavi; James S Welsh; Seyed Mohammad Javad Mortazavi. "How Reactivation of SARS-CoV-2 in Astronauts with Dysregulated Immune Systems Can Negatively Affect the Odds of Success in Future Space Missions". سامانه مدیریت نشریات علمی, 13, 3, 1402, 297-298. doi: 10.31661/jbpe.v0i0.2104-1321
Bevelacqua, Joseph John, Mortazavi, Seyed Alireza, Welsh, James S, Mortazavi, Seyed Mohammad Javad. (1402). 'How Reactivation of SARS-CoV-2 in Astronauts with Dysregulated Immune Systems Can Negatively Affect the Odds of Success in Future Space Missions', سامانه مدیریت نشریات علمی, 13(3), pp. 297-298. doi: 10.31661/jbpe.v0i0.2104-1321
Bevelacqua, Joseph John, Mortazavi, Seyed Alireza, Welsh, James S, Mortazavi, Seyed Mohammad Javad. How Reactivation of SARS-CoV-2 in Astronauts with Dysregulated Immune Systems Can Negatively Affect the Odds of Success in Future Space Missions. سامانه مدیریت نشریات علمی, 1402; 13(3): 297-298. doi: 10.31661/jbpe.v0i0.2104-1321

How Reactivation of SARS-CoV-2 in Astronauts with Dysregulated Immune Systems Can Negatively Affect the Odds of Success in Future Space Missions

Journal of Biomedical Physics and Engineering
دوره 13، شماره 3، مرداد و شهریور 2023، صفحه 297-298    اصل مقاله (555.74 K)
نوع مقاله: Commentary
شناسه دیجیتال (DOI): 10.31661/jbpe.v0i0.2104-1321
نویسندگان
Joseph John Bevelacqua1؛ Seyed Alireza Mortazavi2؛ James S Welsh* 3، 4؛ Seyed Mohammad Javad Mortazavi* 5
1Bevelacqua Resources, Richland, Washington 99352, United States
2School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
3Department of Radiation Oncology Edward Hines Jr VA Hospital Hines, Illinois, United States
4Department of Radiation Oncology, Stritch School of Medicine, Loyola University, Chicago, IL, United States
5Department of Medical Physics and Engineering, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
We have previously reported that during future space missions the risk of severe COVID-19 infection will be a cardinal issue that needs careful attention. Our studies show that even with the most reliable pre-mission screening and quarantine strategies, astronauts with a latent (hidden, inactive, or dormant) SARS-CoV-2 infection might be sent to space. Given this consideration, an asymptomatic individual with dormant SARS-CoV-2 infection may successfully pass all the pre-launch medical tests. Then during a space mission such as a journey to Mars or beyond, when the immune system of these astronauts starts to weaken, the dormant infection may progress to a severe infection that possibly affects the chance of the mission’s success. The effects of microgravity and the elevated space radiation are two key factors that should be evaluated. Furthermore, the limited size of the spacecraft, the proximity of crew members during flight operations, spacecraft atmospheric composition, limited exercise capability, effects of viral response to space radiation, and uncertainty in the likelihood of the virus to mutate and evolve during a space mission merit additional study.
کلیدواژه‌ها
COVID-19؛ SARS-CoV-2؛ Space؛ Reactivation؛ Infections
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مراجع
  1. Mortazavi SAR, Mortazavi SMJ, Sihver L. Can Reactivation of SARS-CoV-2 Decrease the Chance of Success of Future Deep Space Missions? IEEE Aerospace Conference (50100); Big Sky, MT, USA: IEEE; 2021. p. 1-6.
  2. Welsh JS, Bevelacqua JJ, Mozdarani H, Mortazavi SA, Mortazavi SM. Why can COVID-19 fatality in space be significantly higher than on Earth? International Journal of Radiation Research. 2020;18(3):421-6. doi: 10.18869/acadpub.ijrr.18.3.421.
  3. Ing AJ, Cocks C, Green JP. COVID-19: in the footsteps of Ernest Shackleton. 2020;75(8):693-4. doi: 10.1136/thoraxjnl-2020-215091. PubMed PMID: 32461231. PubMed PMCID: PMC7402559.
  4. Byambasuren O, Cardona M, Bell K, Clark J, McLaws ML, Glasziou P. Estimating the extent of asymptomatic COVID-19 and its potential for community transmission: systematic review and meta-analysis. Official Journal of the Association of Medical Microbiology and Infectious Disease Canada. 2020;5(4):223-34. doi: 10.3138/jammi-2020-0030.
  5. Chen Z, Xie W, Ge Z, Wang Y, Zhao H, Wang J, Xu Y, Zhang W, Song M, Cui S, Wang X. Reactivation of SARS-CoV-2 infection following recovery from COVID-19. J Infect Public Health. 2021;14(5):620-7. doi: 10.1016/j.jiph.2021.02.002. PubMed PMID: 33848891. PubMed PMCID: PMC7869688.
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