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Davoudi, Zahra, Bidari, Farahnaz, Jamali, Elena, Nikpour, Shahriar. (1400). Severe Obstructive Cholestasis and Hypercalcemia Caused by Light-Chain Amyloidosis: A Case Report. سامانه مدیریت نشریات علمی, 47(1), 73-77. doi: 10.30476/ijms.2021.88694.1942
Zahra Davoudi; Farahnaz Bidari; Elena Jamali; Shahriar Nikpour. "Severe Obstructive Cholestasis and Hypercalcemia Caused by Light-Chain Amyloidosis: A Case Report". سامانه مدیریت نشریات علمی, 47, 1, 1400, 73-77. doi: 10.30476/ijms.2021.88694.1942
Davoudi, Zahra, Bidari, Farahnaz, Jamali, Elena, Nikpour, Shahriar. (1400). 'Severe Obstructive Cholestasis and Hypercalcemia Caused by Light-Chain Amyloidosis: A Case Report', سامانه مدیریت نشریات علمی, 47(1), pp. 73-77. doi: 10.30476/ijms.2021.88694.1942
Davoudi, Zahra, Bidari, Farahnaz, Jamali, Elena, Nikpour, Shahriar. Severe Obstructive Cholestasis and Hypercalcemia Caused by Light-Chain Amyloidosis: A Case Report. سامانه مدیریت نشریات علمی, 1400; 47(1): 73-77. doi: 10.30476/ijms.2021.88694.1942

Severe Obstructive Cholestasis and Hypercalcemia Caused by Light-Chain Amyloidosis: A Case Report

Iranian Journal of Medical Sciences
مقاله 10، دوره 47، شماره 1، فروردین 2022، صفحه 73-77    اصل مقاله (1.22 M)
نوع مقاله: Case Report(s)
شناسه دیجیتال (DOI): 10.30476/ijms.2021.88694.1942
نویسندگان
Zahra Davoudi1؛ Farahnaz Bidari2؛ Elena Jamali2؛ Shahriar Nikpour* 1
1Department of Internal Medicine, Loghman Hakim Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2Department of Pathology, Loghman Hakim Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
چکیده
Gastrointestinal amyloidosis is a condition caused by the deposition of extracellular protein fragments. It can be associated with complex and diverse pathways and can have numerous manifestations and etiologies. Hepatic amyloid light-chain (AL) amyloidosis is a rare disorder characterized by the deposition of the insoluble amyloid protein in the liver. The clinical presentations of AL amyloidosis are frequently non-specific. In this case report, we describe a patient with amyloidosis, who initially presented with an unusual case of severe intrahepatic cholestasis, which followed a rapidly progressive clinical course that was associated with the acute hypercalcemic crisis. The diagnosis of amyloidosis was made after the liver and bone biopsies were performed. Our findings revealed that AL amyloidosis should be considered, when a patient presents with cholestatic hepatitis, renal failure, and hypercalcemia.
کلیدواژه‌ها
Liver failure؛ Multiple myeloma؛ Amyloidosis
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مراجع
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