High and Moderate Intensity Aerobic Training Effects on Galectin-3, Pentraxin-3, and Several Inflammatory Mediators Levels in Type 2 Diabetic Women, a Randomized Clinical Trial

1. Verma S, Hussain ME. Obesity and diabetes: an update. Diabetes Metab Syndr. 2017;11(1):73-79. doi: 10.1016/j.dsx.2016.06.017. PubMed PMID: 27353549. ## 2. Olokoba AB, Obateru OA, Olokoba LB. Type 2 diabetes mellitus: a review of current trends. Oman Med J. 2012;27(4):269-73. doi: 10.5001/omj.2012.68. PubMed PMID: 23071876; PubMed Central PMCID: PMC6364621. ## 3. Xia C, Rao X, Zhong J. Role of T lymphocytes in type 2 diabetes and diabetes-associated inflammation. J Diabetes Res. 2017;2017:6494795. doi: 10.1155/2017/6494795. PubMed PMID: 28251163; PubMed Central PMCID: PMC5307004. ## 4. Esser N, Legrand-Poels S, Piette J, Scheen AJ, Paquot N. Inflammation as a link between obesity, metabolic syndrome and type 2 diabetes. Diabetes Res Clin Pract. 2014;105(2):141-50. doi: 10.1016/j.diabres.2014.04.006. PubMed PMID: 24798950. ## 5. Rehman K, Akash MSH, Liaqat A, Kamal S, Qadir MI, Rasul A. Role of interleukin-6 in development of insulin resistance and type 2 diabetes mellitus. Crit Rev Eukaryot Gene Expr. 2017;27(3): 229-236. doi: 10.1615/CritRevEukaryotGeneExpr.2017019712. PubMed PMID: 29199608. 6. Kim JH, Bachmann RA, Chen J. Interleukin‐6 and insulin resistance. Vitam Horm. 2009;80:613-33. doi: 10.1016/S0083-6729(08)00621-3. PubMed PMID: 19251052. ## 7. Flores MBS, Rocha GZ, Damas–Souza DM, Osório–Costa F, Dias MM, Ropelle ER, et al. RETRACTED: Obesity-induced increase in tumor necrosis factor-α leads to development of colon cancer in mice. Gastroenterology. 2012;143(3):741-753. doi: 10.1053/j.gastro.2012.05.045. PubMed PMID: 22677195. ## 8. Hogas S, Bilha SC, Branisteanu D, Hogas M, Gaipov A, Kanbay M, et al. Potential novel biomarkers of cardiovascular dysfunction and disease: cardiotrophin-1, adipokines and galectin-3. Arch Med Sci. 2017;13(4):897-913. doi: 10.5114/aoms.2016.58664. PubMed PMID: 28721158; PubMed Central PMCID: PMC5507105. 9. Filipe MD, Meijers WC, van der Velde AR, de Boer RA. Galectin-3 and heart failure: prognosis, prediction & clinical utility. Clinica chimica acta. 2015;443:48-56. doi: 10.1016/j.cca.2014.10.009. PubMed PMID: 25446877. ## 10. Menini S, Iacobini C, Blasetti Fantauzzi C, Pesce CM, Pugliese G. Role of galectin-3 in obesity and impaired glucose homeostasis. Oxid Med Cell Longev. 2016;2016:9618092. doi: 10.1155/2016/9618092. PubMed PMID: 26770660; PubMed Central PMCID: PMC4684889. ## 11. Krautbauer S, Eisinger K, Hader Y, Buechler C. Free fatty acids and IL-6 induce adipocyte galectin-3 which is increased in white and brown adipose tissues of obese mice. Cytokine. 2014;69(2):263-71. doi: 10.1016/j.cyto.2014.06.016. PubMed PMID: 25043674. ## 12. Yang HS, Woo JE, Lee SJ, Park SH, Woo JM. Elevated plasma pentraxin 3 levels are associated with development and progression of diabetic retinopathy in Korean patients with type 2 diabetes mellitus. Invest Ophthalmol Vis Sci. 2014;55(9):5989-97. doi: 10.1167/iovs.14-14864. PubMed PMID: 25159210. ## 13. Lee DH, Jeon HK, You JH, Park MY, Lee SJ, Kim SS, et al. Pentraxin 3 as a novel marker predicting congestive heart failure in subjects with acute coronary syndrome. Korean Circ J. 2010;40(8):370-6. doi: 10.4070/kcj.2010.40.8.370. PubMed PMID: 20830250; PubMed Central PMCID: PMC2933461. ## 14. Bonacina F, Moregola A, Porte R, Baragetti A, Bonavita E, Salatin A, et al. Pentraxin 3 deficiency protects from the metabolic inflammation associated to diet-induced obesity. Cardiovasc Res. 2019;115(13):1861-1872. doi: 10.1093/cvr/cvz068. PubMed PMID: 30859179. ## 15. Jeon YK, Kim SS, Kim JH, Kim HJ, Kim HJ, Park JJ, et al. Combined Aerobic and Resistance Exercise Training Reduces Circulating Apolipoprotein J Levels and Improves Insulin Resistance in Postmenopausal Diabetic Women. Diabetes Metab J. 2020;44(1):103-112. doi: 10.4093/dmj.2018.0160. PubMed PMID: 32097999; PubMed Central PMCID: PMC7043986. ## 16. Wormgoor SG, Dalleck LC, Zinn C, Harris NK. Effects of high-intensity interval training on people living with type 2 diabetes: a narrative review. Can J Diabetes. 2017;41(5):536-547. doi: 10.1016/j.jcjd.2016.12.004. PubMed PMID: 28366674. ## 17. Liubaoerjijin Y, Terada T, Fletcher K, Boulé NG. Effect of aerobic exercise intensity on glycemic control in type 2 diabetes: a meta-analysis of head-to-head randomized trials. Acta Diabetol. 2016;53(5):769-81. doi: 10.1007/s00592-016-0870-0. PubMed PMID: 27255501. ## 18. Ramos JS, Dalleck LC, Tjonna AE, Beetham KS, Coombes JS. The impact of high-intensity interval training versus moderate-intensity continuous training on vascular function: a systematic review and meta-analysis. Sports Med. 2015;45(5):679-92. doi: 10.1007/s40279-015-0321-z. PubMed PMID: 25771785. ## 19. De Nardi AT, Tolves T, Lenzi TL, Signori LU, da Silva AMV. High-intensity interval training versus continuous training on physiological and metabolic variables in prediabetes and type 2 diabetes: a meta-analysis. Diabetes Res Clin Pract. 2018;137:149-159. doi: 10.1016/j.diabres.2017.12.017. PubMed PMID: 29329778. ## 20. Kazemi A, Rostami R, Koushkie Jahromi M, Tahmasebi S. Does Pilates Exercise Change the Memory, Attention and Balance in Women with Lymphedema after Modified Mastectomy? Women Health Bull. 2021;8(1):56-62. doi: 10.30476/WHB.2021.88043.1083. ## 21. Nayebifar SH, Ghasemi E, Karimipour S. Effect of high-intensity interval training and omega-3 supplementation on liver enzymes and lipid profile of young men. Science & Sports. 2020;35(1):1-9. doi: 10.1016/j.scispo.2019.03.004. ## 22. Ghanbari-Niaki A, Saeidi A, Ahmadian M, Gharahcholo L, Naghavi N, Fazelzadeh M, et al. The combination of exercise training and Zataria multiflora supplementation increase serum irisin levels in postmenopausal women. Integr Med Res. 2018;7(1):44-52. doi: 10.1016/j.imr.2018.01.007. PubMed PMID: 29629290; PubMed Central PMCID: PMC5884011. ## 23. Zafra MM, García-Cantó E, García PL, Pérez-Soto JJ, López PJ, Guillamón AR, et al. Influence of a physical exercise programme on VO2max in adults with cardiovascular risk factors. Clin Investig Arterioscler. 2018;30(3):95-101. doi: 10.1016/j.arteri.2017.11.003. PubMed PMID: 29395495. ## 24. Ahmad AM. Moderate-intensity continuous training: is it as good as high-intensity interval training for glycemic control in type 2 diabetes? J Exerc Rehabil. 2019;15(2):327-333. doi: 10.12965/jer.1836648.324. PubMed PMID: 31111021; PubMed Central PMCID: PMC6509469. ## 25. Schjerve IE, Tyldum GA, Tjønna AE, Stølen T, Loennechen JP, Hansen HEM, et al. Both aerobic endurance and strength training programmes improve cardiovascular health in obese adults. Clin Sci. 2008;115(9):283-93. doi: 10.1042/CS20070332. PubMed PMID: 18338980. ## 26. Onishi Y, Hayashi T, Sato KK, Ogihara T, Kuzuya N, Anai M, et al. Fasting tests of insulin secretion and sensitivity predict future prediabetes in Japanese with normal glucose tolerance. J Diabetes Investig. 2010;1(5):191-5. doi: 10.1111/j.2040-1124.2010.00041. x. PubMed PMID: 24843431; PubMed Central PMCID: PMC4020720. ## 27. Pugliese G, Iacobini C, Pesce CM, Menini S. Galectin-3: an emerging all-out player in metabolic disorders and their complications. Glycobiology. 2014;25(2):136-50. doi: 10.1093/glycob/cwu111. PubMed PMID: 25303959. ## 28. Salvagno GL, Schena F, Gelati M, Danese E, Cervellin G, Guidi GC, Lippi G. The concentration of high-sensitivity troponin I, galectin-3 and NT-proBNP substantially increase after a 60-km ultramarathon. Clin Chem Lab Med. 2014;52(2):267-72. doi: 10.1515/cclm-2013-0601. PubMed PMID: 24088611. ## 29. Zaidi H, Byrkjeland R, Njerve IU, Åkra S, Solheim S, Arnesen H, et al. Effects of exercise training on markers of adipose tissue remodeling in patients with coronary artery disease and type 2 diabetes mellitus: sub study of the randomized controlled EXCADI trial. Diabetol Metab Syndr. 2019;11:109. doi: 10.1186/s13098-019-0508-9. PubMed PMID: 31890043; PubMed Central PMCID: PMC6923919. ## 30. Moghadami K, Khalafi M, Shabani M. The effect of aerobic training on serum levels of Galectin3 and inflammatory markers in elderly women with metabolic syndrome: a randomized clinical trial. Jundishapur Scientific Medical Journal. 2020;18(6):639-648. doi: 10.22118/JSMJ.2020.212952.1926. Persian. ## 31. Khajeian N, Moghadasi M. Effect of 8 weeks regular endurance training on galectin-3 changes after a strenuous aerobic exercise. Journal of Physical Activity and Hormones. 2017;1(3):29-38. ## 32. Kingwell K. Diabetes: turning down galectin 3 to combat insulin resistance. Nat Rev Drug Discov. 2016;16(1):18. doi: 10.1038/nrd.2016.276. PubMed PMID: 28031565. ## 33. Kiwaki K, Novak CM, Hsu DK, Liu FT, Levine JA. Galectin‐3 stimulates preadipocyte proliferation and is up‐regulated in growing adipose tissue. Obesity. 2007;15(1):32-9. doi: 10.1038/oby.2007.526. PubMed PMID: 17228029. ## 34. Farinha JB, Steckling FM, Stefanello ST, Cardoso MS, Nunes LS, Barcelos RP, et al. Response of oxidative stress and inflammatory biomarkers to a 12-week aerobic exercise training in women with metabolic syndrome. Sports Med Open. 2015;1(1):19. doi: 10.1186/s40798-015-0011-2. PubMed PMID: 26284160; PubMed Central PMCID: PMC5005613. ## 35. Gleeson M, Bishop NC, Stensel DJ, Lindley MR, Mastana SS, Nimmo MA. The anti-inflammatory effects of exercise: mechanisms and implications for the prevention and treatment of disease. Nat Rev Immunol. 2011;11(9):607-15. doi: 10.1038/nri3041. PubMed PMID: 21818123. ## 36. Karakas MF, Buyukkaya E, Kurt M, Motor S, Akcay AB, Karakas E, et al. Serum pentraxin-3 levels are associated with the severity of metabolic syndrome. Med Princ Pract. 2013;22(3):274-9. doi: 10.1159/000343904. PubMed PMID: 23146973; PubMed Central PMCID: PMC5586734. ## 37. Wang R, Zhang J, Hu W. Association of serum pentraxin 3 concentrations with diabetic nephropathy. J Investig Med. 2016; 64(6):1124-7. doi: 10.1136/jim-2016-000082. PubMed PMID: 27233528. ## 38. Todoric J, Handisurya A, Knapp B, Tura A, Pacini G, Kautzky‐Willer A. Relationship of pentraxin 3 with insulin sensitivity in gestational diabetes. Eur J Clin Invest. 2013;43(4):341-9. doi: 10.1111/eci.12051. PubMed PMID: 23379644. ## 39. Slusher AL, Huang CJ, Acevedo EO. The potential role of aerobic exercise-induced pentraxin 3 on obesity-related inflammation and metabolic dysregulation. Mediators inflamm. 2017;2017:1092738. doi: 10.1155/2017/1092738. PubMed PMID: 28400677; PubMed Central PMCID: PMC5376480. ## 40. Hovsepian V, Marandi SM, Esfarjani F, Zavar R, Sadeghi M. The Effect of All-Extremity High-Intensity Interval Training on Plasma Pentraxin 3 in Young Overweight and Obese Women. Asian J Sports Med. 2019;10(4):e92849. doi: 10.5812/asjsm.92849. ## 41. Madsen SM, Thorup AC, Bjerre M, Jeppesen PB. Does 8 weeks of strenuous bicycle exercise improve diabetes-related inflammatory cytokines and free fatty acids in type 2 diabetes patients and individuals at high-risk of metabolic syndrome? Arch Physiol Biochem. 2015;121(4):129-38. doi: 10.3109/13813455.2015.1082600. PubMed PMID: 26469542. ## 42. Zempo-Miyaki A, Kumagai H, Yoshikawa T, Myoenzono K, So R, Otsuki T, Tanaka K, et al. Pentraxin 3 increases in adult overweight and obese men after weight loss by dietary modification with exercise training. Appl Physiol Nutr Metab. 2019;44(2):111-117. doi: 10.1139/apnm-2018-0214. PubMed PMID: 29990442. ##