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Su, QingXiao, Jiang, LiJun, Chai, Jia, Dou, ZhiYan, Rong, ZanHua, Zhao, Xue, Yu, Bo, Wang, YuXue, Wang, XinLiang. (1400). Changes of Peripheral Blood Lymphocyte Subsets and Immune Function in Children with Henoch-Schonlein Purpura Nephritis. سامانه مدیریت نشریات علمی, 18(3), 259-267. doi: 10.22034/iji.2021.89742.1964
QingXiao Su; LiJun Jiang; Jia Chai; ZhiYan Dou; ZanHua Rong; Xue Zhao; Bo Yu; YuXue Wang; XinLiang Wang. "Changes of Peripheral Blood Lymphocyte Subsets and Immune Function in Children with Henoch-Schonlein Purpura Nephritis". سامانه مدیریت نشریات علمی, 18, 3, 1400, 259-267. doi: 10.22034/iji.2021.89742.1964
Su, QingXiao, Jiang, LiJun, Chai, Jia, Dou, ZhiYan, Rong, ZanHua, Zhao, Xue, Yu, Bo, Wang, YuXue, Wang, XinLiang. (1400). 'Changes of Peripheral Blood Lymphocyte Subsets and Immune Function in Children with Henoch-Schonlein Purpura Nephritis', سامانه مدیریت نشریات علمی, 18(3), pp. 259-267. doi: 10.22034/iji.2021.89742.1964
Su, QingXiao, Jiang, LiJun, Chai, Jia, Dou, ZhiYan, Rong, ZanHua, Zhao, Xue, Yu, Bo, Wang, YuXue, Wang, XinLiang. Changes of Peripheral Blood Lymphocyte Subsets and Immune Function in Children with Henoch-Schonlein Purpura Nephritis. سامانه مدیریت نشریات علمی, 1400; 18(3): 259-267. doi: 10.22034/iji.2021.89742.1964

Changes of Peripheral Blood Lymphocyte Subsets and Immune Function in Children with Henoch-Schonlein Purpura Nephritis

Iranian Journal of Immunology
مقاله 11، دوره 18، شماره 3، آذر 2021، صفحه 259-267    اصل مقاله (633.41 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22034/iji.2021.89742.1964
نویسندگان
QingXiao Su1؛ LiJun Jiang2؛ Jia Chai2؛ ZhiYan Dou2؛ ZanHua Rong1؛ Xue Zhao1؛ Bo Yu2؛ YuXue Wang3؛ XinLiang Wang* 1
1Department of Peadiatrics, The Second Hospital of HeBei Medical University, ShiJiaZhuang, China
2Department of Peadiatrics, The Second Hospital of HeBei Medical University, ShiJiaZhuang , China
3Department of Peadiatrics, The Second Hospital of HeBei Medical University, ShiJiaZhuang 050000, China
چکیده
Background: Purpuric nephritis is the most common secondary glomerular disease in childhood. Its prevalence in children has been steadily rising in recent years. Objective: To explore the characteristics and pathogenesis of changes in peripheral blood lymphocyte subsets and immune function in children with Henoch-Schonlein purpura nephritis. Methods: The study included 104 children with Henoch-Schonlein purpura, divided into nephritis (HSPN) group (68 cases) and non-nephritis (NHSPN) group (36 cases), and 15 normal children. The rate-scatter turbidimetric method was utilized to determine the immunoglobulins IgA, IgG, IgM, C3 and C4, and the flow cytometry technique was employed to detect the levels of lymphocyte subsets including CD3+, CD4+, CD8+, CD4+/CD8+, CD19+, NK, etc. Results: Compared with the control group, the CD3+, CD4+, CD8+ and NK cell levels of peripheral blood mononuclear cells significantly decreased (p <0.05), and the CD19+ level significantly elevated (p <0.05) in the HSPN group and the NHSPN group whereas the HSPN group had a more significant change than the NHSPN group (p <0.05). Compared with the control group, the serum immunoglobulin IgA and IgG of the HSPN group and the NHSPN group significantly increased, and the IgM, C3, and C4 significantly decreased (p <0.05); while the HSPN group had a more significant change than the NHSPN group (p <0.05). Conclusion: Immune dysfunction in children with HSPN is specifically manifested as low cellular immune function, which leads to increased secretion of inflammatory mediators, activates B cells, and further increases the secretion of immunoglobulins, leading to the occurrence of small vasculitis.
کلیدواژه‌ها
Complement؛ Henoch-Schonlein Purpura؛ Immunoglobulin؛ Lymphocyte Subsets؛ Purpuric Nephritis
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