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He, Yanni, Yang, Qiaorong, Zhang, Tong, Zeng, Yibin, Du, Lingbo, Wang, Wuqing. (1400). Pathogenic characteristics of Th17 cells based on IL-17 signaling pathway in regulation of sebaceous gland lipoprotein metabolism in acne rat model. سامانه مدیریت نشریات علمی, 18(3), 203-209. doi: 10.22034/iji.2021.88231.1855
Yanni He; Qiaorong Yang; Tong Zhang; Yibin Zeng; Lingbo Du; Wuqing Wang. "Pathogenic characteristics of Th17 cells based on IL-17 signaling pathway in regulation of sebaceous gland lipoprotein metabolism in acne rat model". سامانه مدیریت نشریات علمی, 18, 3, 1400, 203-209. doi: 10.22034/iji.2021.88231.1855
He, Yanni, Yang, Qiaorong, Zhang, Tong, Zeng, Yibin, Du, Lingbo, Wang, Wuqing. (1400). 'Pathogenic characteristics of Th17 cells based on IL-17 signaling pathway in regulation of sebaceous gland lipoprotein metabolism in acne rat model', سامانه مدیریت نشریات علمی, 18(3), pp. 203-209. doi: 10.22034/iji.2021.88231.1855
He, Yanni, Yang, Qiaorong, Zhang, Tong, Zeng, Yibin, Du, Lingbo, Wang, Wuqing. Pathogenic characteristics of Th17 cells based on IL-17 signaling pathway in regulation of sebaceous gland lipoprotein metabolism in acne rat model. سامانه مدیریت نشریات علمی, 1400; 18(3): 203-209. doi: 10.22034/iji.2021.88231.1855

Pathogenic characteristics of Th17 cells based on IL-17 signaling pathway in regulation of sebaceous gland lipoprotein metabolism in acne rat model

Iranian Journal of Immunology
مقاله 5، دوره 18، شماره 3، آذر 2021، صفحه 203-209    اصل مقاله (1.16 M)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22034/iji.2021.88231.1855
نویسندگان
Yanni He1؛ Qiaorong Yang2؛ Tong Zhang1؛ Yibin Zeng1؛ Lingbo Du1؛ Wuqing Wang* 1
1Department of Dermatology, Minhang Hospital Affiliated to Fudan University, Shanghai, 201199, China.
2Department of Dermatology, Zhongshan Hospital Fudan University, Shanghai, 200032, China.
چکیده
Background: Acne is a common and chronic inflammatory dermatosis of sebaceous gland units of the human hair follicle. Acne is closely related to immune cytokines and cells including T helper 17cells (Th17 cells). Mis-regulated glycolipid metabolism also plays a vital role in the process. Objective: This investigation aimed to explore the role of IL-17 in signaling pathways controlling sebaceous gland lipoprotein metabolism in a rat model of acne. Methods: We generated the rat ear acne model, and investigated the pathological changes of acne skin tissue by histological analysis and the changes in the critical factors including DEFB1, GPR65, FADS1, and FADS2 by Western Blot in this model. Results: There were more Th17 cells in the rat ear acne model than in the control mice. The expression levels of DEFB1, GPR65, FADS1, FADS2 and MOGAT1 were significantly upregulated in serum and tissue from rat acne model, which could be concluded that the Th17 cells play a major role in the pathogenesis of acne based. Conclusion: Although acne is associated with immune effects and glycolipid metabolism, inhibition of IL-17 signaling pathway might be a novel way for acne therapy. Our findings also suggest a new strategy for targeted therapy of acne.
کلیدواژه‌ها
Acne؛ IL-17 Signal Pathway؛ Metabolism؛ Sebaceous Gland Lipoprotein؛ Th17 Cells
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