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Wang, Xueqin, Gao, Yingying, Ge, Xingyu, Gu, Zhifeng. (1400). The association between the decreased expression levels of FOXJ1 and the activation of NF-κB pathway in interstitial lung disease of MRL/Lpr mice. سامانه مدیریت نشریات علمی, 18(3), 210-219. doi: 10.22034/iji.2021.89385.1944
Xueqin Wang; Yingying Gao; Xingyu Ge; Zhifeng Gu. "The association between the decreased expression levels of FOXJ1 and the activation of NF-κB pathway in interstitial lung disease of MRL/Lpr mice". سامانه مدیریت نشریات علمی, 18, 3, 1400, 210-219. doi: 10.22034/iji.2021.89385.1944
Wang, Xueqin, Gao, Yingying, Ge, Xingyu, Gu, Zhifeng. (1400). 'The association between the decreased expression levels of FOXJ1 and the activation of NF-κB pathway in interstitial lung disease of MRL/Lpr mice', سامانه مدیریت نشریات علمی, 18(3), pp. 210-219. doi: 10.22034/iji.2021.89385.1944
Wang, Xueqin, Gao, Yingying, Ge, Xingyu, Gu, Zhifeng. The association between the decreased expression levels of FOXJ1 and the activation of NF-κB pathway in interstitial lung disease of MRL/Lpr mice. سامانه مدیریت نشریات علمی, 1400; 18(3): 210-219. doi: 10.22034/iji.2021.89385.1944

The association between the decreased expression levels of FOXJ1 and the activation of NF-κB pathway in interstitial lung disease of MRL/Lpr mice

Iranian Journal of Immunology
مقاله 6، دوره 18، شماره 3، آذر 2021، صفحه 210-219    اصل مقاله (1.77 M)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22034/iji.2021.89385.1944
نویسندگان
Xueqin Wang* 1؛ Yingying Gao2؛ Xingyu Ge1؛ Zhifeng Gu1
1Department of Rheumatology, the Medical School of Nantong University, Nantong, China.
2Department of Rheumatology, the First People’s Hospital of Nantong, The Second Affiliated Hospital of Nantong University, Nantong, China.
چکیده
Background: Pulmonary manifestations of systemic lupus erythematosus (SLE) are appearing in 4-5% of patients involving lung in almost half of the cases during the disease course. Objective: We compared the autoimmune pulmonary inflammation in the lung tissue of mice to determine the association between decreased expression levels of Forkhead Box J1 (FOXJ1) and the activation of the NF-κB pathway in autoimmune pulmonary inflammation of MRL/Lpr mice. Methods: The female BALB/c mice (n=6) and MRL/Lpr mice (n=30) were divided into 5 groups including a control group (BALB/c), and five MRL/Lpr mice groups (8W, 12W, 16W, 24W, and 32W). The infiltration of the inflammatory cells was determined in lung tissue by performing the histological analysis. The western blotting was used to examine the expression levels of the age-related FOXJ1, and p50 and p65 proteins in the lungs of MRL/Lpr mice. The expression levels of MMP2 and MMP9 were determined via immunohistochemistry and immunofluorescence. Results: There were severe infiltrates of lung cells with high levels of tracheal damage, perivascular injury and interstitial inflammatory cell infiltration when the MRL/Lpr mice from 16w to 32w comparing to the 8w old healthy MRL/Lpr mice in the control group (p <0.05). Moreover, the reduced expression levels of FOXJ1 were associated with the activation of the NF-κB pathway in interstitial lung disease of MRL/Lpr mice via the modulation of p50 and p65. In addition, the expression levels of MMP2 and MMP9 pro-inflammation factors increased in the lungs of the MRL/Lpr mice from 16w to 32w. Conclusions: The expression level of FOXJ1 might be an indicator of the degree of lung disease in lupus-prone mice.
کلیدواژه‌ها
Forkhead-box j1؛ Interstitial Lung Disease؛ Systemic Disease؛ Systemic Lupus Erythematous
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