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Marashi, Sayed Mahdi, Izadi, Shima, Najafizadeh, Seyed Reza, Nejati, Ahmad, Teymoori-Rad, Majid, Shahmahmoodi, Shohreh, Golsaz-Shirazi, Forough, Shokri, Fazel. (1400). Overall status of Epstein-Barr virus infection, IFN-α, and TLR-7/9 in patients with Systemic Lupus Erythematosus. سامانه مدیریت نشریات علمی, 18(3), 230-240. doi: 10.22034/iji.2021.87648.1814
Sayed Mahdi Marashi; Shima Izadi; Seyed Reza Najafizadeh; Ahmad Nejati; Majid Teymoori-Rad; Shohreh Shahmahmoodi; Forough Golsaz-Shirazi; Fazel Shokri. "Overall status of Epstein-Barr virus infection, IFN-α, and TLR-7/9 in patients with Systemic Lupus Erythematosus". سامانه مدیریت نشریات علمی, 18, 3, 1400, 230-240. doi: 10.22034/iji.2021.87648.1814
Marashi, Sayed Mahdi, Izadi, Shima, Najafizadeh, Seyed Reza, Nejati, Ahmad, Teymoori-Rad, Majid, Shahmahmoodi, Shohreh, Golsaz-Shirazi, Forough, Shokri, Fazel. (1400). 'Overall status of Epstein-Barr virus infection, IFN-α, and TLR-7/9 in patients with Systemic Lupus Erythematosus', سامانه مدیریت نشریات علمی, 18(3), pp. 230-240. doi: 10.22034/iji.2021.87648.1814
Marashi, Sayed Mahdi, Izadi, Shima, Najafizadeh, Seyed Reza, Nejati, Ahmad, Teymoori-Rad, Majid, Shahmahmoodi, Shohreh, Golsaz-Shirazi, Forough, Shokri, Fazel. Overall status of Epstein-Barr virus infection, IFN-α, and TLR-7/9 in patients with Systemic Lupus Erythematosus. سامانه مدیریت نشریات علمی, 1400; 18(3): 230-240. doi: 10.22034/iji.2021.87648.1814

Overall status of Epstein-Barr virus infection, IFN-α, and TLR-7/9 in patients with Systemic Lupus Erythematosus

Iranian Journal of Immunology
مقاله 8، دوره 18، شماره 3، آذر 2021، صفحه 230-240    اصل مقاله (1.33 M)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22034/iji.2021.87648.1814
نویسندگان
Sayed Mahdi Marashi* 1؛ Shima Izadi2؛ Seyed Reza Najafizadeh3؛ Ahmad Nejati2؛ Majid Teymoori-Rad4؛ Shohreh Shahmahmoodi5؛ Forough Golsaz-Shirazi6؛ Fazel Shokri7
1Virology Department, School of Public Health, Tehran University of Medical Sciences, Tehran 14155, Iran
2Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
3Rheumatology Research Center, Imam Khomeini hospital, Tehran University of Medical Sciences, Tehran, Iran
4Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
5Virology Division, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
6Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
7Department of Immunology, schoolof public health,Tehran university of medical sciences, Tehran, Iran
چکیده
Background: Systemic lupus erythematous (SLE) is a multisystem autoimmune disorder. While studying the pathogenesis of SLE is prevalent, both infectious and non-infectious elements are regarded to exert an important impact on the disease's development. Objective: To explore the overall status of EBV, TLR7, TLR9, and IFN-α gene expression in 32 patients suffering from SLE and 32 healthy controls. Methods: Plasma and PBMCs were separated from fresh whole blood. To measure EBV DNA load and mRNA levels of IFN-a, TLR-7 and9 in PBMCs, molecular techniques were employed. The production of IFN-α, ds-DNA IgG antibody, and EBNA-1 IgG levels were also measured in plasma by ELISA. Results: SLE patients showed significantly higher EBV load (p=0.001) and transcriptional levels of TLR7 (p=0.0001), IFN-α (p=0.0001), and TLR9 (p=0.0001) than controls. Moreover, the plasma levels of IFN-α (p=0.0002) and EBNA-1specific IgG antibodies (p=0.01) were significantly higher in SLE patients. Conclusion: The results stressed on the potential role of EBV infection and TLRs in SLE patients although more research is needed to determine the global impact that EBV infection can have on immune signature in patients with SLE.
کلیدواژه‌ها
Epstein-Barr Virus؛ IFN-α؛ Systemic Lupus Erythematous؛ Toll-like Receptors
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