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Interleukin-10 Promoter and the CCR5 Polymorphisms in Iranian Azari Population with Multiple Sclerosis | ||
| Iranian Journal of Immunology | ||
| مقاله 9، دوره 18، شماره 3، آذر 2021، صفحه 241-248 اصل مقاله (513.72 K) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.22034/iji.2021.83883.1634 | ||
| نویسندگان | ||
| Mohammad Asgharzadeh1؛ Davoud Sanajou2؛ Hossein Samadi Kafil3؛ Mehdi Farhoudi4؛ Daryoush Savadi Oskouei5؛ Fatemeh Khaki-Khatibi2؛ Fatemeh Ahmadi6؛ Manouchehr Fadaee7؛ Ali Vegari8؛ Vahid Asgharzadeh9؛ Jalil Rashedi* 10؛ Behroz Mahdavi Poor11؛ Pourya Gholizadeh12 | ||
| 1Biotechnology Research Center and Faculty of Paramedicine, Tabriz University of Medical Sciences, Tabriz, Iran. | ||
| 2Department of Clinical Biochemistry, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran | ||
| 3Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. | ||
| 4Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran | ||
| 5Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. | ||
| 6Department of Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran | ||
| 7Department of Immunology, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| 8Department of Medical Physics, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran. | ||
| 9Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran | ||
| 10Tabriz University of Medical Sciences | ||
| 11Department of Laboratory Sciences, School of Paramedicine, Tabriz University of Medical Sciences, Tabriz, Iran | ||
| 12Tabriz University of medical sciences | ||
| چکیده | ||
| Background: Changes in the expression of cytokines as the result of the single nucleotide polymorphisms (SNPs), can affect the incidence of multiple sclerosis (MS). Objective: To investigate the relationship between the frequencies of interleukin-10 (IL-10)-1082 A/G (rs1800896) and CCR5-delta32 genotypes and susceptibility to MS in the Iranian Azari population. Methods: IL-10-1082 A/G SNP and the CCR5-delta32 were genotyped in 152 patients suffering from MS and 242 healthy non-relatives by allele specific-PCR and simple PCR methods, respectively. Results: The frequencies of AA (37.6%) and AG (55.9%) genotypes of IL-10-1082 were significantly high in the control (p = 0.021) and MS patients (p = 0.015), respectively, with no statistical difference between these groups. There was no significant difference in the CCR5 gene based on the possession of wild/wild and wild/del32 genotypes between MS patients and the control group. The del32/del32 genotype was not seen in any of the investigated groups. Tobacco (cigarettes and hookahs) consumption was higher among the MS patients (p=0.004), and this has the potential to raise the risk of MS in both the individuals and their family. However, it had no significant relation with the frequency of different genotypes of the IL-10-1082 and the CCR5. Conclusion: Our finding conclude on possible role of AA genotype of IL-10 -1082 as a protective factor in MS. | ||
| کلیدواژه‌ها | ||
| CCR5؛ Delta 32؛ Interleukin-10؛ Multiple Sclerosis؛ Polymorphism | ||
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