Risk Factors for the Mortality in Hospitalized Patients with COVID-19: A Brief Report | ||
| Iranian Journal of Medical Sciences | ||
| مقاله 9، دوره 46، شماره 6، بهمن 2021، صفحه 487-492 اصل مقاله (253.63 K) | ||
| نوع مقاله: Brief Report(s) | ||
| شناسه دیجیتال (DOI): 10.30476/ijms.2021.47835 | ||
| نویسندگان | ||
| Ramin Sami1؛ Mohammad-Reza Hajian1؛ Babak Amra2؛ Forogh Soltaninejad1؛ Marjan Mansourian3؛ Sam Mirfendereski4؛ Raheleh Sadegh5؛ Nilufar Khademi1؛ Soheila Jalali6؛ Nafiseh Shokri-Mashhadi* 7 | ||
| 1Department of Internal Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran | ||
| 2Bamdad Respiratory and Sleep Research Center, Department of Internal Medicine, Pulmonary and Sleep Ward, Isfahan University of Medical Sciences, Isfahan, Iran | ||
| 3Pediatric Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran | ||
| 4Department of Radiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran | ||
| 5Department of Community and Prevention Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran | ||
| 6Department of Epidemiology and Biostatistics, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran | ||
| 7Department of Clinical Nutrition, School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan, Iran | ||
| چکیده | ||
| The cumulative rate of death of acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has necessitated better recognizing the risk factors of the disease and the COVID-19-induced mortality. This cross-sectional study aimed to determine the potential risk factors that predict COVID-19-related mortality concentrating on the initial recorded laboratory tests. We extracted admission’s medical records of a total of 136 deaths related to COVID-19 and 272 discharged adult inpatients (≥18 years old) related to four referral centers from February 24th to April 12th, 2020, in Isfahan, Iran, to figure out the relationship between the laboratory findings and mortality beyond demographic and clinical findings. We applied the independent sample t test and a chichi square test with SPSS software to compare the differences between the survivor and non-survivor patients. A P value of less than 0.05 was considered significant. Our results showed that greater length of hospitalization (P≤0.001), pre-existing chronic obstructive pulmonary disease (P≤0.001), high pulse rate, hypoxia (P≤0.001), and high computed tomography scan score (p <0.001), in addition to high values of some laboratory parameters, increase the risk of mortality. Moreover, high neutrophil/lymphocyte ratio (OR, 1.890; 95% CI, 1.074-3.325, P=0.027), increased creatinine levels (OR, 15.488; 95% CI, 0.801-299.479, P=0.07), and elevated potassium levels (OR, 13.400; 95% CI, 1.084-165.618, P=0.043) independently predicted in-hospital death related to COVID-19 infection. These results emphasized the potential role of impaired laboratory parameters for the prognosis of fatal outcomes in adult inpatients. | ||
| کلیدواژهها | ||
| COVID-19؛ Risk factors؛ Mortality؛ Medical laboratory science | ||
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