LinkedIn

 آمار

تعداد نشریات20
تعداد شماره‌ها1,149
تعداد مقالات10,518
تعداد مشاهده مقاله45,415,528
تعداد دریافت فایل اصل مقاله11,291,332
Emami, Soodabeh, Panah, Ashkan, Hakimi, Seyed Shaheen, Sahmeddini, Mohammad Ali. (1400). Effect of Caffeine on the Acceleration of Emergence from General Anesthesia with Inhalation Anesthetics in Children undergoing Inguinal Herniorrhaphy: A Randomized Clinical Trial. سامانه مدیریت نشریات علمی, 47(2), 107-113. doi: 10.30476/ijms.2021.87688.1818
Soodabeh Emami; Ashkan Panah; Seyed Shaheen Hakimi; Mohammad Ali Sahmeddini. "Effect of Caffeine on the Acceleration of Emergence from General Anesthesia with Inhalation Anesthetics in Children undergoing Inguinal Herniorrhaphy: A Randomized Clinical Trial". سامانه مدیریت نشریات علمی, 47, 2, 1400, 107-113. doi: 10.30476/ijms.2021.87688.1818
Emami, Soodabeh, Panah, Ashkan, Hakimi, Seyed Shaheen, Sahmeddini, Mohammad Ali. (1400). 'Effect of Caffeine on the Acceleration of Emergence from General Anesthesia with Inhalation Anesthetics in Children undergoing Inguinal Herniorrhaphy: A Randomized Clinical Trial', سامانه مدیریت نشریات علمی, 47(2), pp. 107-113. doi: 10.30476/ijms.2021.87688.1818
Emami, Soodabeh, Panah, Ashkan, Hakimi, Seyed Shaheen, Sahmeddini, Mohammad Ali. Effect of Caffeine on the Acceleration of Emergence from General Anesthesia with Inhalation Anesthetics in Children undergoing Inguinal Herniorrhaphy: A Randomized Clinical Trial. سامانه مدیریت نشریات علمی, 1400; 47(2): 107-113. doi: 10.30476/ijms.2021.87688.1818

Effect of Caffeine on the Acceleration of Emergence from General Anesthesia with Inhalation Anesthetics in Children undergoing Inguinal Herniorrhaphy: A Randomized Clinical Trial

Iranian Journal of Medical Sciences
مقاله 5، دوره 47، شماره 2، خرداد 2022، صفحه 107-113    اصل مقاله (503.23 K)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/ijms.2021.87688.1818
نویسندگان
Soodabeh Emami؛ Ashkan Panah* ؛ Seyed Shaheen Hakimi؛ Mohammad Ali Sahmeddini
Anesthesiology and Critical Care Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Background: Awakening following general anesthesia (GA) is one of the most important concerns of anesthesiologists in their daily work. Previous studies on adult humans found that caffeine could accelerate awakening after anesthesia. This study aimed to determine whether or not caffeine can accelerate awakening after anesthesia in children undergoing inguinal herniorrhaphy under GA.
Methods: In this randomized clinical trial, we enrolled 18 children undergoing inguinal herniorrhaphy under GA with inhaled anesthetics from June 2019 to September 2019 in the tertiary hospital affiliated with Shiraz University of Medical Sciences (Shiraz, Iran). These children were randomly allocated to two groups. In group A, the children received intravenous caffeine (10 mg/Kg) at the end of the surgery, and in group B, the children received intravenous normal saline at the end of the surgery. The primary outcome was laryngeal mask airway (LMA) removal time at the end of anesthesia. Intra-operative hemodynamic data and side effects such as nausea, vomiting, dysrhythmia, cyanosis, and seizures in the recovery room were recorded and compared between the two groups. We used the independent-samples t test, Fisher’s exact test, and repeated measures ANOVA for analyzing the data. P valuesResults: There were no significant differences in terms of demographic characteristics and hemodynamic data between the two groups. Furthermore, the time from the induction of anesthesia to laryngeal mask removal was 44.77±7.87 min in the placebo group and 44.55±10.68 min in the caffeine group. Therefore, there was no significant difference between the two groups (P=0.961).
Conclusion: In children undergoing inguinal herniorrhaphy under GA, 10 mg/Kg of caffeine could not accelerate awakening from GA. However, caffeine did not increase the blood pressure and heart rate in the children, and no significant side effects were observed.
Trial Registration Number: IRCT20190511043550N1.
کلیدواژه‌ها
Caffeine؛ General anesthesia؛ Delayed emergence from anesthesia؛ Hernia؛ Inguinal
سایر فایل های مرتبط با مقاله
مراجع
  1. Solt K, Cotten JF, Cimenser A, Wong KF, Chemali JJ, Brown EN. Methylphenidate actively induces emergence from general anesthesia. Anesthesiology. 2011;115:791-803. doi: 10.1097/ALN.0b013e31822e92e5. PubMed PMID: 21934407; PubMed Central PMCID: PMCPMC3178041.
  2. Fong R, Khokhar S, Chowdhury AN, Xie KG, Wong JH, Fox AP, et al. Caffeine accelerates recovery from general anesthesia via multiple pathways. J Neurophysiol. 2017;118:1591-7. doi: 10.1152/jn.00393.2017. PubMed PMID: 28659466; PubMed Central PMCID: PMCPMC5596131.
  3. Cascella M, Bimonte S, Di Napoli R. Delayed Emergence from Anesthesia: What We Know and How We Act. Local Reg Anesth. 2020;13:195-206. doi: 10.2147/LRA.S230728. PubMed PMID: 33177867; PubMed Central PMCID: PMCPMC7652217.
  4. Fong R, Wang L, Zacny JP, Khokhar S, Apfelbaum JL, Fox AP, et al. Caffeine Accelerates Emergence from Isoflurane Anesthesia in Humans: A Randomized, Double-blind, Crossover Study. Anesthesiology. 2018;129:912-20. doi: 10.1097/ALN.0000000000002367. PubMed PMID: 30044241; PubMed Central PMCID: PMCPMC6191316.
  5. Yang A, Palmer AA, de Wit H. Genetics of caffeine consumption and responses to caffeine. Psychopharmacology (Berl). 2010;211:245-57. doi: 10.1007/s00213-010-1900-1. PubMed PMID: 20532872; PubMed Central PMCID: PMCPMC4242593.
  6. Son Y. Molecular mechanisms of general anesthesia. Korean J Anesthesiol. 2010;59:3-8. doi: 10.4097/kjae.2010.59.1.3. PubMed PMID: 20651990; PubMed Central PMCID: PMCPMC2908224.
  7. Thomas E, Martin F, Pollard B. Delayed recovery of consciousness after general anaesthesia. BJA Educ. 2020;20:173-9. doi: 10.1016/j.bjae.2020.01.007. PubMed PMID: 33456947; PubMed Central PMCID: PMCPMC7807841.
  8. Chemali JJ, Van Dort CJ, Brown EN, Solt K. Active emergence from propofol general anesthesia is induced by methylphenidate. Anesthesiology. 2012;116:998-1005. doi: 10.1097/ALN.0b013e3182518bfc. PubMed PMID: 22446983; PubMed Central PMCID: PMCPMC3339625.
  9. Fox AP, Wagner KR, Towle VL, Xie KG, Xie Z. Caffeine reverses the unconsciousness produced by light anesthesia in the continued presence of isoflurane in rats. PLoS One. 2020;15:e0241818. doi: 10.1371/journal.pone.0241818. PubMed PMID: 33152041; PubMed Central PMCID: PMCPMC7643991.
  10. Ferre S. An update on the mechanisms of the psychostimulant effects of caffeine. J Neurochem. 2008;105:1067-79. doi: 10.1111/j.1471-4159.2007.05196.x. PubMed PMID: 18088379.
  11. Lazarus M, Shen HY, Cherasse Y, Qu WM, Huang ZL, Bass CE, et al. Arousal effect of caffeine depends on adenosine A2A receptors in the shell of the nucleus accumbens. J Neurosci. 2011;31:10067-75. doi: 10.1523/JNEUROSCI.6730-10.2011. PubMed PMID: 21734299; PubMed Central PMCID: PMCPMC3153505.
  12. van Koert RR, Bauer PR, Schuitema I, Sander JW, Visser GH. Caffeine and seizures: A systematic review and quantitative analysis. Epilepsy Behav. 2018;80:37-47. doi: 10.1016/j.yebeh.2017.11.003. PubMed PMID: 29414557.
  13. Daabiss M. American Society of Anaesthesiologists physical status classification. Indian J Anaesth. 2011;55:111-5. doi: 10.4103/0019-5049.79879. PubMed PMID: 21712864; PubMed Central PMCID: PMCPMC3106380.
  14. Moncel JB, Nardi N, Wodey E, Pouvreau A, Ecoffey C. Evaluation of the pediatric post anesthesia discharge scoring system in an ambulatory surgery unit. Paediatr Anaesth. 2015;25:636-41. doi: 10.1111/pan.12612. PubMed PMID: 25581378.
  15. Moschino L, Zivanovic S, Hartley C, Trevisanuto D, Baraldi E, Roehr CC. Caffeine in preterm infants: where are we in 2020? ERJ Open Res. 2020;6. doi: 10.1183/23120541.00330-2019. PubMed PMID: 32154294; PubMed Central PMCID: PMCPMC7049734.
  16. Sumpter A, Anderson BJ. Pediatric pharmacology in the first year of life. Curr Opin Anaesthesiol. 2009;22:469-75. doi: 10.1097/aco.0b013e32832bc7ff. PubMed PMID: 19593898.
آمار
تعداد مشاهده مقاله: 5,259
تعداد دریافت فایل اصل مقاله: 3,042


سامانه مدیریت نشریات علمی. قدرت گرفته از سیناوب