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Cerdan-Santacruz, Carlos, Codina-Corrons, Laia, Merichal-Resina, Mireia, Milla-Collado, Lucia, Trujillano-Cabello, Javier, Tarragona-Foradada, Jordi, Mestres-Petit, Nuria, Sierra-Grañón, Enrique, Olsina-Kissler, Jorge. (1400). Factors associated with higher rate of Complete Pathologic Response after Long-Course Neoadjuvant Treatment for Locally Advanced Rectal Cancer Patients – Results from a retrospective cohort study focused on Inflammatory Indexes. سامانه مدیریت نشریات علمی, 9(3), 90-97. doi: 10.30476/acrr.2021.47811
Carlos Cerdan-Santacruz; Laia Codina-Corrons; Mireia Merichal-Resina; Lucia Milla-Collado; Javier Trujillano-Cabello; Jordi Tarragona-Foradada; Nuria Mestres-Petit; Enrique Sierra-Grañón; Jorge Olsina-Kissler. "Factors associated with higher rate of Complete Pathologic Response after Long-Course Neoadjuvant Treatment for Locally Advanced Rectal Cancer Patients – Results from a retrospective cohort study focused on Inflammatory Indexes". سامانه مدیریت نشریات علمی, 9, 3, 1400, 90-97. doi: 10.30476/acrr.2021.47811
Cerdan-Santacruz, Carlos, Codina-Corrons, Laia, Merichal-Resina, Mireia, Milla-Collado, Lucia, Trujillano-Cabello, Javier, Tarragona-Foradada, Jordi, Mestres-Petit, Nuria, Sierra-Grañón, Enrique, Olsina-Kissler, Jorge. (1400). 'Factors associated with higher rate of Complete Pathologic Response after Long-Course Neoadjuvant Treatment for Locally Advanced Rectal Cancer Patients – Results from a retrospective cohort study focused on Inflammatory Indexes', سامانه مدیریت نشریات علمی, 9(3), pp. 90-97. doi: 10.30476/acrr.2021.47811
Cerdan-Santacruz, Carlos, Codina-Corrons, Laia, Merichal-Resina, Mireia, Milla-Collado, Lucia, Trujillano-Cabello, Javier, Tarragona-Foradada, Jordi, Mestres-Petit, Nuria, Sierra-Grañón, Enrique, Olsina-Kissler, Jorge. Factors associated with higher rate of Complete Pathologic Response after Long-Course Neoadjuvant Treatment for Locally Advanced Rectal Cancer Patients – Results from a retrospective cohort study focused on Inflammatory Indexes. سامانه مدیریت نشریات علمی, 1400; 9(3): 90-97. doi: 10.30476/acrr.2021.47811

Factors associated with higher rate of Complete Pathologic Response after Long-Course Neoadjuvant Treatment for Locally Advanced Rectal Cancer Patients – Results from a retrospective cohort study focused on Inflammatory Indexes

Iranian Journal of Colorectal Research
مقاله 2، دوره 9، شماره 3، آذر 2021، صفحه 90-97    اصل مقاله (826.39 K)
نوع مقاله: Research/Original Article
شناسه دیجیتال (DOI): 10.30476/acrr.2021.47811
نویسندگان
Carlos Cerdan-Santacruz* 1؛ Laia Codina-Corrons2؛ Mireia Merichal-Resina3؛ Lucia Milla-Collado4؛ Javier Trujillano-Cabello5؛ Jordi Tarragona-Foradada6؛ Nuria Mestres-Petit7؛ Enrique Sierra-Grañón8؛ Jorge Olsina-Kissler9
1Hospital Universitario de la Princesa, Madrid, Spain
2Hospital Universitario Arnau de Vilanova, Lleida, Spain Universitat de Lleida
3Department of General Surgery, Hospital Universitari Arnau de Vilanova, Lleida, Spain
4Thoracic Surgery at Hospital General de la Defensa Gomez Ulla, Madrid, Spain
5Biomedical Research Institute, Lleida, Spain
6Department of Anatomopathology, Hospital Universitari Arnau de Vilanova, Lleida, Spain
7Department of Colorectal Surgery, Hospital Universitari Arnau de Vilanova, Lleida, Spain
8Head of the Colorectal Surgery Unit, Department of General Surgery, Hospital Arnau de Vilanova, Lleida, Spain
9Department of Chief of the General Surgery, Hospital Arnau de Vilanova, Lleida, Spain
چکیده
BACKGROUND: Pathologic complete response (pCR) after neoadjuvant chemoradiotherapy (NCRT) has a prognostic value in locally advanced rectal cancer (LARC). This study aimed to evaluate the ability to predict pCR using inflammatory markers, facilitating the selection of the optimal treatment strategy.
METHODS: Patients undergoing primary tumor resection after long-cycle NCRT at a single center (2012 to 2018) were retrospectively collected (n=130). Patient demographics, preoperative laboratory measurements, tumor characteristics, treatment strategy, and postoperative anatomopathological variables were collected. The association of factors to pCR was examined using binary logistic regression, odds ratio (OR) (95% confidence interval), and the discriminative capacity with the ROC curve.
RESULTS: Out of 130 patients, 42 pCRs occurred, equal to 32.3% of the sample. Variables identified as useful to predict pCR were total neutrophil count (3; OR 7.6), intravenous 5-FU chemotherapy strategy (OR 3.2), and absence of diabetes (OR 3.4). Patients having all three of them had a 55.3% chance of pCR.
CONCLUSIONS: The absolute neutrophil count better predicts pCR than other inflammatory indices in selected patients with LARC undergoing long-cycle NCRT. A neutrophil count less than 6400 cells/mm3, absence of diabetes, and intravenous 5-FU NCRT therapy lead to a relative rise in pCR.
کلیدواژه‌ها
Pathologic complete response؛ neoadjuvant chemoradiotherapy؛ inflammatory indexes؛ neutrophil؛ rectal cancer؛ tumor regression
مراجع
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