Zafari, Zahra, Ayatollahi, Hossein, Sohrabi, Tayebeh, Arbab Jafari, Pourya, Esmaeili, Habibollah, Keramati, Mohammad Reza. (1401). BMI-1 Gene Expression in Patients with Acute and Chronic Myeloid Leukemia in the Northeast of Iran. سامانه مدیریت نشریات علمی, 14(1), 41-48. doi: 10.30476/mejc.2021.90564.1580
Zahra Zafari; Hossein Ayatollahi; Tayebeh Sohrabi; Pourya Arbab Jafari; Habibollah Esmaeili; Mohammad Reza Keramati. "BMI-1 Gene Expression in Patients with Acute and Chronic Myeloid Leukemia in the Northeast of Iran". سامانه مدیریت نشریات علمی, 14, 1, 1401, 41-48. doi: 10.30476/mejc.2021.90564.1580
Zafari, Zahra, Ayatollahi, Hossein, Sohrabi, Tayebeh, Arbab Jafari, Pourya, Esmaeili, Habibollah, Keramati, Mohammad Reza. (1401). 'BMI-1 Gene Expression in Patients with Acute and Chronic Myeloid Leukemia in the Northeast of Iran', سامانه مدیریت نشریات علمی, 14(1), pp. 41-48. doi: 10.30476/mejc.2021.90564.1580
Zafari, Zahra, Ayatollahi, Hossein, Sohrabi, Tayebeh, Arbab Jafari, Pourya, Esmaeili, Habibollah, Keramati, Mohammad Reza. BMI-1 Gene Expression in Patients with Acute and Chronic Myeloid Leukemia in the Northeast of Iran. سامانه مدیریت نشریات علمی, 1401; 14(1): 41-48. doi: 10.30476/mejc.2021.90564.1580

BMI-1 Gene Expression in Patients with Acute and Chronic Myeloid Leukemia in the Northeast of Iran

Middle East Journal of Cancer
مقاله 4، دوره 14، شماره 1 - شماره پیاپی 53، 2023، صفحه 41-48    اصل مقاله (1.09 M)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/mejc.2021.90564.1580
نویسندگان
Zahra Zafari1؛ Hossein Ayatollahi2؛ Tayebeh Sohrabi1؛ Pourya Arbab Jafari1؛ Habibollah Esmaeili3؛ Mohammad Reza Keramati* 2
1Department of Hematology and Blood Bank, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
2Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
3Social Determination of Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
چکیده
Background: The B-cell-specific Moloney murine leukemia virus integration site1 (BMI-1) is one of the famous members of the Polycomb ring finger group, which plays a crucial role in the gene transcription regulation through histone changes. Hence, it is believed to be necessary to further clarify the clinical effects of  BMI-1.
Method: This cross-sectional study was conducted on 70 acute myeloid leukemia (AML), 70 chronic myeloid leukemia (CML), and 20 healthy individuals, as the control group. We used real-time quantitative polymerase chain reaction in order to assess the BMI-1 level expression and its effect on prognosis in AML patients in the Molecular Pathology Research Center.
Results: The results of the present work indicated that the BMI-1 overexpression was significantly higher in the AML and CML patients compared with that in the healthy controls (P < 0.001). Furthermore, a significant relationship was observed between the BMI-1 overexpression and poor prognosis in the AML patients (Hazard ratio=1.749, P < 0.001, 95% confidence interval = 1.31-2.32). Additionally, BMI- 1high was found in chronic and blastic phase in the CML patients (P < 0.001).
Conclusion: We concluded that investigation of BMI-1 gene expression pattern will be conducive to the prognosis and treatment of myeloid leukemia.
کلیدواژه‌ها
BMI-1 gene؛ Acute؛ Myeloid؛ Leukemia؛ Chronic myeloid leukemia؛ Prognostic effect
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