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Evaluation of the Expression Levels of Notch Signaling Pathway-Related Genes; JAG1, CXCR4, and MIB1 in Acute Myeloid Leukemia Patients | ||
| Middle East Journal of Cancer | ||
| مقاله 2، دوره 13، شماره 4 - شماره پیاپی 52، دی 2022، صفحه 573-580 اصل مقاله (1.38 M) | ||
| نوع مقاله: Original Article(s) | ||
| شناسه دیجیتال (DOI): 10.30476/mejc.2021.89042.1504 | ||
| نویسندگان | ||
| Seyedeh Hananeh Ghafelehbashi1؛ Dina Sadeghizadeh2؛ Fatemeh Rohollah2؛ Saghar Pahlavanneshan3؛ Majid Sadeghizadeh* 1 | ||
| 1Department of Molecular Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran | ||
| 2Department of Cellular and Molecular Sciences, Faculty of Advanced Sciences and Technology, Tehran University of Medical Sciences, Islamic Azad university, Tehran, Iran | ||
| 3Functional Neurosurgery Research Center, Shohada Tajrish Neurosurgical Comprehensive Center of Excellence, Shahid Beheshti University of Medical Sciences, Tehran, Iran | ||
| چکیده | ||
| Background: Acute myeloid leukemia (AML) is a complex disease characterized by clonal expansion of undifferentiated myeloid precursors, resulting in impaired hematopoiesis and bone marrow failure. Different genetic and environmental factors are believed to be involved in the pathogenesis of AML. Notch signaling with a tumor suppressing plays a role in myeloproliferative disorder and is a negative regulator of myeloid progenitor commitment. Crosstalk between Notch signaling and CXCR4 axis is a matter of debate in AML. Method: In the current case-control study, we evaluated the expression level of CXCR4, JAG1, and MIB1, which are all involved or related to Notch signaling in adult AML patients. Blood samples were obtained from 25 AML and 17 healthy individuals and the expression level of the selected genes was evaluated via the real-time polymerase chain reaction. Results: Our results revealed the increased expression of JAG1, but decreased expression of CXCR4 in AML patients in Iranian population of AML patients. Moreover, some gender-associated effects on the expression of JAG1 and CXCR4 were detected, which may be related to sex hormones. The expression level of MIB1 did not change significantly. The correlation analysis showed no correlations between the age of the patients and the expression levels of the genes. Conclusion: Herein, for the first time, we suggested some new evidence regarding the complex role of Notch signaling-related genes (CXCR4 and JAG1) in the pathogenesis of AML in Iranian patients. | ||
| کلیدواژه‌ها | ||
| Notch؛ JAG1؛ CXCR4؛ MIB1؛ Acute myeloid leukemia | ||
| اصل مقاله | ||
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How to cite this article: Ghafelehbashi SH, Sadeghizadeh D, Rohollah F, Pahlavanneshan S, Sadeghizadeh M. Evaluation of the expression levels of Notch signaling pathway-related genes; JAG1, CXCR4, and MIB1 in acute myeloid leukemia patients. Middle East J Cancer. 2022;13(4):573-80. doi: 10.30476/mejc.2021.89042. 1504. | ||
| مراجع | ||
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