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Ebrahimi, Hossein-Ali, Larizadeh, Mohammad-Hasan, Saba, Mohammad, Jafarzadeh, Abdollah. (1402). Radiotherapy Improves the Disability in Patients with Secondary Progressive Multiple Sclerosis. سامانه مدیریت نشریات علمی, 13(4), 317-322. doi: 10.31661/jbpe.v0i0.2012-1238
Hossein-Ali Ebrahimi; Mohammad-Hasan Larizadeh; Mohammad Saba; Abdollah Jafarzadeh. "Radiotherapy Improves the Disability in Patients with Secondary Progressive Multiple Sclerosis". سامانه مدیریت نشریات علمی, 13, 4, 1402, 317-322. doi: 10.31661/jbpe.v0i0.2012-1238
Ebrahimi, Hossein-Ali, Larizadeh, Mohammad-Hasan, Saba, Mohammad, Jafarzadeh, Abdollah. (1402). 'Radiotherapy Improves the Disability in Patients with Secondary Progressive Multiple Sclerosis', سامانه مدیریت نشریات علمی, 13(4), pp. 317-322. doi: 10.31661/jbpe.v0i0.2012-1238
Ebrahimi, Hossein-Ali, Larizadeh, Mohammad-Hasan, Saba, Mohammad, Jafarzadeh, Abdollah. Radiotherapy Improves the Disability in Patients with Secondary Progressive Multiple Sclerosis. سامانه مدیریت نشریات علمی, 1402; 13(4): 317-322. doi: 10.31661/jbpe.v0i0.2012-1238

Radiotherapy Improves the Disability in Patients with Secondary Progressive Multiple Sclerosis

Journal of Biomedical Physics and Engineering
مقاله 3، دوره 13، شماره 4، مهر و آبان 2023، صفحه 317-322    اصل مقاله (644.99 K)
نوع مقاله: Original Research
شناسه دیجیتال (DOI): 10.31661/jbpe.v0i0.2012-1238
نویسندگان
Hossein-Ali Ebrahimi* 1؛ Mohammad-Hasan Larizadeh1؛ Mohammad Saba2؛ Abdollah Jafarzadeh3، 4
1Neurology Research Center, Department of Neurology, Kerman University of Medical Sciences, Kerman, Iran
2Department of Radiology, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran
3Department of Immunology, Medical School, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
4Department of Immunology, Medical School, Kerman University of Medical Sciences, Kerman, Iran
چکیده
Background: Multiple sclerosis (MS) as a complex neurological abnormality is marked with loss of myelin and axons due to chronic inflammatory and autoimmune responses. The modulatory properties of the low dose radiation (LDR) on inflammatory and immune responses have well known.
Objective: The current research aimed to assess the impacts of LDR on the disability in patients suffering from MS.
Material and Methods: This experimental pilot study was done on 10 patients with secondary progressive multiple sclerosis (SPMS). After magnetic resonance imaging, the SPMS patients were treated by LDR at a daily dose of 2 Gray for 5 consecutive days (totally 10 Gray dose) using a linear accelerator. The extent of the disability was evaluated one week after the completion of radiotherapy using expanded disability status scale (EDSS).
Results: After receiving radiotherapy, the patients had a feeling of wellbeing of some sort. The mean of EDSS was significantly reduced after radiotherapy compared with before irradiation (7.4±0.45 vs 6.35±1.18; P<0.017). EDSS more decreased in younger SPMS patients (P=0.0001), and in the women after LDR (P=0.027). 
Conclusion: Radiotherapy can reduce fatigue and EDSS in patients with SPMS. The age and gender of patients may influence the LDR efficacy.

تازه های تحقیق

Hossein-Ali Ebrahimi (Google Scholar)

کلیدواژه‌ها
Human؛ Autoimmune Disease؛ Multiple Sclerosis؛ Radiotherapy؛ Disability
سایر فایل های مرتبط با مقاله
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