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Nsonwu-Anyanwu, Augusta, Icha, Bassey, Nsonwu, Magnus, William, Mbetobong, Emughupogh, Krukru, Usoro, Chinyere. (1401). Assessment of Essential and Non-essential Elements as Risk Evaluation Indices in Men with Prostate Cancer in Calabar South-South Nigeria. سامانه مدیریت نشریات علمی, 13(2), 285-292. doi: 10.30476/mejc.2021.86638.1361
Augusta Chinyere Nsonwu-Anyanwu; Bassey Edward Icha; Magnus Chinonye Nsonwu; Mbetobong Ime William; Krukru Stephen Emughupogh; Chinyere Adanna Opara Usoro. "Assessment of Essential and Non-essential Elements as Risk Evaluation Indices in Men with Prostate Cancer in Calabar South-South Nigeria". سامانه مدیریت نشریات علمی, 13, 2, 1401, 285-292. doi: 10.30476/mejc.2021.86638.1361
Nsonwu-Anyanwu, Augusta, Icha, Bassey, Nsonwu, Magnus, William, Mbetobong, Emughupogh, Krukru, Usoro, Chinyere. (1401). 'Assessment of Essential and Non-essential Elements as Risk Evaluation Indices in Men with Prostate Cancer in Calabar South-South Nigeria', سامانه مدیریت نشریات علمی, 13(2), pp. 285-292. doi: 10.30476/mejc.2021.86638.1361
Nsonwu-Anyanwu, Augusta, Icha, Bassey, Nsonwu, Magnus, William, Mbetobong, Emughupogh, Krukru, Usoro, Chinyere. Assessment of Essential and Non-essential Elements as Risk Evaluation Indices in Men with Prostate Cancer in Calabar South-South Nigeria. سامانه مدیریت نشریات علمی, 1401; 13(2): 285-292. doi: 10.30476/mejc.2021.86638.1361

Assessment of Essential and Non-essential Elements as Risk Evaluation Indices in Men with Prostate Cancer in Calabar South-South Nigeria

Middle East Journal of Cancer
مقاله 9، دوره 13، شماره 2 - شماره پیاپی 50، تیر 2022، صفحه 285-292    اصل مقاله (212.3 K)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/mejc.2021.86638.1361
نویسندگان
Augusta Chinyere Nsonwu-Anyanwu* 1؛ Bassey Edward Icha2؛ Magnus Chinonye Nsonwu3؛ Mbetobong Ime William1؛ Krukru Stephen Emughupogh1؛ Chinyere Adanna Opara Usoro1
1Department of Medical Laboratory Science, University of Calabar, Calabar, Nigeria
2Department of Chemical Pathology, University of Calabar Teaching Hospital, Calabar, Nigeria
3Department of Optometry, Imo State University, Owerri, Nigeria
چکیده
Background: Heavy metal (HM) toxicity has been described as a risk factor for the development of prostate disease in men and its assessment could predict susceptibility to prostate cancer (PCa). The current study aimed to assess the levels of HM (selenium [Se], copper [Cu], chromium [Cr] and lead [Pb], iron [Fe], zinc [Zn], magnesium [Mg], and cobalt [Co]) in men with PCa.
Method: 90 men aged 40 to 75 years, including 30 men with PCa, 30 with benign prostatic hyperplasia (BPH), and 30 controls, were recruited in this case-control study. Prostate specific antigen (PSA) was estimated via enzyme linked immunosorbent assay and heavy metals with atomic absorption spectrophotometry. Body mass index (BMI) was also determined.
Results: The men with PCa had significantly higher BMI, PSA, Fe, and Pb and lower Mg, Zn, Cu, and Se compared with the controls. They also had higher PSA, Fe, and Co compared with the BPH (P < 0.05). Those with BPH had higher BMI, PSA, and Fe and lower Mg, Zn, Cu, Se, and Co compared with the controls (P < 0.05). Zn was positively correlated with Mg (r = 0.937, P < 0.001, Cu (r = 0.548, P = 0.002), Se (r = 0.731, P < 0.001), and Co (r=0.733, P < 0.001) only in the men with PCa. Levels of Cu, Mg, and Se were associated with the risk of BPH and PCa.
Conclusion: The men with prostate disease were found to have higher levels of lead and iron and lower magnesium, copper, selenium, and zinc, which necessitate assessment of these elements for early detection of prostate cancer and monitoring the progression of the disease.
کلیدواژه‌ها
Metals؛ Heavy؛ Prostate؛ Neoplasms
اصل مقاله

How to cite this article:

Nsonwu-Anyanwu AC, Icha BE, Nsonwu MC, William MI, Emughupogh KT, Opara Usoro CA. Assessment of essential and non-essential elements as risk evaluation indices in men with prostate cancer in Calabar South-South Nigeria. Middle East J Cancer. 2022;13(2):285- 92. doi: 10.30476/mejc.2021. 86638.1361.

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