Family History of Alzheimer’s Disease Increases the Risk of COVID-19 Positivity: A SUMS Employees Cohort-based Study | ||
| Journal of Biomedical Physics and Engineering | ||
| مقاله 8، دوره 13، شماره 4، آبان 2023، صفحه 363-366 اصل مقاله (598.49 K) | ||
| نوع مقاله: Original Research | ||
| شناسه دیجیتال (DOI): 10.31661/jbpe.v0i0.2104-1318 | ||
| نویسندگان | ||
| Seyed Jalil Masoumi1، 2، 3؛ Masoud Haghani4؛ Pooneh Mokkaram5؛ Donya Firoozi6؛ Seyed Ali Reza Mortazavi7؛ Fariba Moradi Ardekani3؛ Atefeh Torabi Ardakani3؛ Seyed Mohammad Javad Mortazavi* 8 | ||
| 1Nutrition Research Center, School of Nutrition and Food Sciences, Shiraz University of Medical Science, Shiraz, Iran | ||
| 2Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| 3Center for Cohort Study of SUMS Employees’ Health, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| 4Department of Radiology, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| 5Department of Biochemistry, Autophagy Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| 6Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| 7School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| 8Department of Medical Physics and Engineering, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| چکیده | ||
| Background: Substantial data indicate that genetic and environmental factors play a key role in determining the risk of Alzheimer’s disease (AD). Moreover, it is known that having relatives with AD increases the risk of developing this disease. Objective: This study is aimed at investigating whether having a family history of AD, may increase the risk of COVID-19 in a cohort-based study. Material and Methods: Participants of this retrospective cohort study were previously enrolled in the SUMS Employees Cohort (SUMSEC). All participants including those whose SARS-CoV-2 infection was confirmed by positive PCR test and chest CT scan were requested to respond to interviewer-administered questionnaires. Moreover, AD was diagnosed via memory and thinking impairment, concentration problems, confusion with location, and problems in finishing daily tasks. Results: The total numbers of female and male participants with a family history of AD were 463 and 222 individuals, respectively. When all types of family history of AD were considered, a 51.3% increase was found in the relative frequency of the participants with both family history of AD and confirmed COVID-19 compared with those only with a family history of AD. Conclusion: Despite the limitations of our study, and from a broader perspective, our findings can further support the concept that AD risk haplotypes including APOE are linked to the same morbidities from cardiovascular disease and obesity that increase vulnerability to COVID-19. Given this consideration, millions of APOE ε4 carriers around the globe should be advised to take additional precautions to prevent life-threatening diseases such as COVID-19. | ||
تازه های تحقیق | ||
Seyed Jalil Masoumi (Google Scholar) Seyed Mohammad Javad Mortazavi (Google Scholar) | ||
| کلیدواژهها | ||
| Alzheimer’s Disease؛ APOe4 Gene؛ SARS-CoV-2؛ COVID-19 | ||
| مراجع | ||
|
| ||
|
آمار تعداد مشاهده مقاله: 32,772 تعداد دریافت فایل اصل مقاله: 38,672 |
||