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Masoumi, Seyed Jalil, Haghani, Masoud, Mokkaram, Pooneh, Firoozi, Donya, Mortazavi, Seyed Ali Reza, Moradi Ardekani, Fariba, Torabi Ardakani, Atefeh, Mortazavi, Seyed Mohammad Javad. (1402). Family History of Alzheimer’s Disease Increases the Risk of COVID-19 Positivity: A SUMS Employees Cohort-based Study. سامانه مدیریت نشریات علمی, 13(4), 363-366. doi: 10.31661/jbpe.v0i0.2104-1318
Seyed Jalil Masoumi; Masoud Haghani; Pooneh Mokkaram; Donya Firoozi; Seyed Ali Reza Mortazavi; Fariba Moradi Ardekani; Atefeh Torabi Ardakani; Seyed Mohammad Javad Mortazavi. "Family History of Alzheimer’s Disease Increases the Risk of COVID-19 Positivity: A SUMS Employees Cohort-based Study". سامانه مدیریت نشریات علمی, 13, 4, 1402, 363-366. doi: 10.31661/jbpe.v0i0.2104-1318
Masoumi, Seyed Jalil, Haghani, Masoud, Mokkaram, Pooneh, Firoozi, Donya, Mortazavi, Seyed Ali Reza, Moradi Ardekani, Fariba, Torabi Ardakani, Atefeh, Mortazavi, Seyed Mohammad Javad. (1402). 'Family History of Alzheimer’s Disease Increases the Risk of COVID-19 Positivity: A SUMS Employees Cohort-based Study', سامانه مدیریت نشریات علمی, 13(4), pp. 363-366. doi: 10.31661/jbpe.v0i0.2104-1318
Masoumi, Seyed Jalil, Haghani, Masoud, Mokkaram, Pooneh, Firoozi, Donya, Mortazavi, Seyed Ali Reza, Moradi Ardekani, Fariba, Torabi Ardakani, Atefeh, Mortazavi, Seyed Mohammad Javad. Family History of Alzheimer’s Disease Increases the Risk of COVID-19 Positivity: A SUMS Employees Cohort-based Study. سامانه مدیریت نشریات علمی, 1402; 13(4): 363-366. doi: 10.31661/jbpe.v0i0.2104-1318

Family History of Alzheimer’s Disease Increases the Risk of COVID-19 Positivity: A SUMS Employees Cohort-based Study

Journal of Biomedical Physics and Engineering
مقاله 8، دوره 13، شماره 4، مهر و آبان 2023، صفحه 363-366    اصل مقاله (598.49 K)
نوع مقاله: Original Research
شناسه دیجیتال (DOI): 10.31661/jbpe.v0i0.2104-1318
نویسندگان
Seyed Jalil Masoumi1، 2، 3؛ Masoud Haghani4؛ Pooneh Mokkaram5؛ Donya Firoozi6؛ Seyed Ali Reza Mortazavi7؛ Fariba Moradi Ardekani3؛ Atefeh Torabi Ardakani3؛ Seyed Mohammad Javad Mortazavi* 8
1Nutrition Research Center, School of Nutrition and Food Sciences, Shiraz University of Medical Science, Shiraz, Iran
2Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
3Center for Cohort Study of SUMS Employees’ Health, Shiraz University of Medical Sciences, Shiraz, Iran
4Department of Radiology, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran
5Department of Biochemistry, Autophagy Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
6Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran
7School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
8Department of Medical Physics and Engineering, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Background: Substantial data indicate that genetic and environmental factors play a key role in determining the risk of Alzheimer’s disease (AD). Moreover, it is known that having relatives with AD increases the risk of developing this disease.
Objective: This study is aimed at investigating whether having a family history of AD, may increase the risk of COVID-19 in a cohort-based study.
Material and Methods: Participants of this retrospective cohort study were previously enrolled in the SUMS Employees Cohort (SUMSEC). All participants including those whose SARS-CoV-2 infection was confirmed by positive PCR test and chest CT scan were requested to respond to interviewer-administered questionnaires. Moreover, AD was diagnosed via memory and thinking impairment, concentration problems, confusion with location, and problems in finishing daily tasks.
Results: The total numbers of female and male participants with a family history of AD were 463 and 222 individuals, respectively. When all types of family history of AD were considered, a 51.3% increase was found in the relative frequency of the participants with both family history of AD and confirmed COVID-19 compared with those only with a family history of AD. 
Conclusion: Despite the limitations of our study, and from a broader perspective, our findings can further support the concept that AD risk haplotypes including APOE are linked to the same morbidities from cardiovascular disease and obesity that increase vulnerability to COVID-19. Given this consideration, millions of APOE ε4 carriers around the globe should be advised to take additional precautions to prevent life-threatening diseases such as COVID-19.

تازه های تحقیق

Seyed Jalil Masoumi (Google Scholar)

Seyed Mohammad Javad Mortazavi (Google Scholar)

کلیدواژه‌ها
Alzheimer’s Disease؛ APOe4 Gene؛ SARS-CoV-2؛ COVID-19
سایر فایل های مرتبط با مقاله
مراجع
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