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Kazemi, Mohammad Hossein, Kuhestani Dehaghi, Bentolhoda, Roshandel, Elham, Bonakchi, Hossein, Parkhideh, Sayeh, Mehdizadeh, Mahshid, Hajifathali, Abbas. (1400). Association of HScore Parameters with Severe COVID-19: A Systematic Review and Meta-Analysis. سامانه مدیریت نشریات علمی, 46(5), 322-338. doi: 10.30476/ijms.2021.88404.1910
Mohammad Hossein Kazemi; Bentolhoda Kuhestani Dehaghi; Elham Roshandel; Hossein Bonakchi; Sayeh Parkhideh; Mahshid Mehdizadeh; Abbas Hajifathali. "Association of HScore Parameters with Severe COVID-19: A Systematic Review and Meta-Analysis". سامانه مدیریت نشریات علمی, 46, 5, 1400, 322-338. doi: 10.30476/ijms.2021.88404.1910
Kazemi, Mohammad Hossein, Kuhestani Dehaghi, Bentolhoda, Roshandel, Elham, Bonakchi, Hossein, Parkhideh, Sayeh, Mehdizadeh, Mahshid, Hajifathali, Abbas. (1400). 'Association of HScore Parameters with Severe COVID-19: A Systematic Review and Meta-Analysis', سامانه مدیریت نشریات علمی, 46(5), pp. 322-338. doi: 10.30476/ijms.2021.88404.1910
Kazemi, Mohammad Hossein, Kuhestani Dehaghi, Bentolhoda, Roshandel, Elham, Bonakchi, Hossein, Parkhideh, Sayeh, Mehdizadeh, Mahshid, Hajifathali, Abbas. Association of HScore Parameters with Severe COVID-19: A Systematic Review and Meta-Analysis. سامانه مدیریت نشریات علمی, 1400; 46(5): 322-338. doi: 10.30476/ijms.2021.88404.1910

Association of HScore Parameters with Severe COVID-19: A Systematic Review and Meta-Analysis

Iranian Journal of Medical Sciences
مقاله 2، دوره 46، شماره 5، آذر 2021، صفحه 322-338    اصل مقاله (4.57 M)
نوع مقاله: Review Article
شناسه دیجیتال (DOI): 10.30476/ijms.2021.88404.1910
نویسندگان
Mohammad Hossein Kazemi1، 2؛ Bentolhoda Kuhestani Dehaghi1، 3؛ Elham Roshandel1؛ Hossein Bonakchi1، 4؛ Sayeh Parkhideh1؛ Mahshid Mehdizadeh1؛ Abbas Hajifathali* 1
1Hematopoietic Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2Department of Immunology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
3Department of Hematology and Blood Banking, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4Department of Biostatistics, School of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
چکیده
Background: Several reports have associated the severe Coronavirus disease-2019 (sCOVID-19) with secondary-hemophagocytic lymphohistiocytosis (sHLH) and proposed utilizing the hemophagocytic syndrome diagnostic score (HScore) for sCOVID-19 patients. We conducted a systematic review and meta-analysis to find the possible association of HScore parameters with severity in COVID-19 patients.
Methods: A systematic search was performed in Medline via PubMed, EMBASE, and Cochrane databases using all HScore and COVID-19 keywords. The studies were all from 2020, and the study language was limited to English. The records were screened based on inclusion/exclusion criteria. Random/fixed-effect models were employed for meta-analysis, based on the I2 index of parameters. The pooled mean differences were estimated for continuous parameters. The pooled odds-ratio was estimated for fever. The level of significance was set at 0.05.
Results: Eighteen studies (comprising 2459 patients) out of 26151 screened studies were included in this meta-analysis. The results showed that the level of leukocyte, neutrophil, aspartate transaminase (AST), ferritin, and fibrinogen were significantly higher in sCOVID-19 patients than in non-severe ones. Significant lower levels of lymphocyte, platelet, and hemoglobin were also found in sCOVID-19 patients than non-severe patients. Fever was nearly associated with two times increased odds of sCOVID-19 (P=0.051).
Conclusion: Lymphopenia, thrombocytopenia, hypohemoglobinemia, hyperferritinemia, high levels of AST, and fever are common features of both sCOVID-19 and HLH. However, the leukocytosis, neutrophilia, and hyperfibrinogenemia found in sCOVID-19 are in contrast with HScore. Conclusively, HScore parameters could be risk factors for sCOVID-19. However, some parameters’ roles are contradictory, suggesting the need for further investigation and a new way of HScore interpretation in sCOVID-19 patients.
A preprint of this study was published at https://www.researchsquare.com/article/rs-54490/v2.
کلیدواژه‌ها
COVID-19؛ Hemophagocytic lymphohistiocytosis؛ Systematic review؛ Meta-analysis
سایر فایل های مرتبط با مقاله
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