LinkedIn

 آمار

تعداد نشریات20
تعداد شماره‌ها1,149
تعداد مقالات10,518
تعداد مشاهده مقاله45,416,232
تعداد دریافت فایل اصل مقاله11,292,096
Kazemi, Mohammad Hossein, Kuhestani Dehaghi, Bentolhoda, Roshandel, Elham, Bonakchi, Hossein, Parkhideh, Sayeh, Mehdizadeh, Mahshid, Hajifathali, Abbas. (1400). Association of HScore Parameters with Severe COVID-19: A Systematic Review and Meta-Analysis. سامانه مدیریت نشریات علمی, 46(5), 322-338. doi: 10.30476/ijms.2021.88404.1910
Mohammad Hossein Kazemi; Bentolhoda Kuhestani Dehaghi; Elham Roshandel; Hossein Bonakchi; Sayeh Parkhideh; Mahshid Mehdizadeh; Abbas Hajifathali. "Association of HScore Parameters with Severe COVID-19: A Systematic Review and Meta-Analysis". سامانه مدیریت نشریات علمی, 46, 5, 1400, 322-338. doi: 10.30476/ijms.2021.88404.1910
Kazemi, Mohammad Hossein, Kuhestani Dehaghi, Bentolhoda, Roshandel, Elham, Bonakchi, Hossein, Parkhideh, Sayeh, Mehdizadeh, Mahshid, Hajifathali, Abbas. (1400). 'Association of HScore Parameters with Severe COVID-19: A Systematic Review and Meta-Analysis', سامانه مدیریت نشریات علمی, 46(5), pp. 322-338. doi: 10.30476/ijms.2021.88404.1910
Kazemi, Mohammad Hossein, Kuhestani Dehaghi, Bentolhoda, Roshandel, Elham, Bonakchi, Hossein, Parkhideh, Sayeh, Mehdizadeh, Mahshid, Hajifathali, Abbas. Association of HScore Parameters with Severe COVID-19: A Systematic Review and Meta-Analysis. سامانه مدیریت نشریات علمی, 1400; 46(5): 322-338. doi: 10.30476/ijms.2021.88404.1910

Association of HScore Parameters with Severe COVID-19: A Systematic Review and Meta-Analysis

Iranian Journal of Medical Sciences
مقاله 2، دوره 46، شماره 5، آذر 2021، صفحه 322-338    اصل مقاله (4.57 M)
نوع مقاله: Review Article
شناسه دیجیتال (DOI): 10.30476/ijms.2021.88404.1910
نویسندگان
Mohammad Hossein Kazemi1، 2؛ Bentolhoda Kuhestani Dehaghi1، 3؛ Elham Roshandel1؛ Hossein Bonakchi1، 4؛ Sayeh Parkhideh1؛ Mahshid Mehdizadeh1؛ Abbas Hajifathali* 1
1Hematopoietic Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2Department of Immunology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
3Department of Hematology and Blood Banking, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4Department of Biostatistics, School of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
چکیده
Background: Several reports have associated the severe Coronavirus disease-2019 (sCOVID-19) with secondary-hemophagocytic lymphohistiocytosis (sHLH) and proposed utilizing the hemophagocytic syndrome diagnostic score (HScore) for sCOVID-19 patients. We conducted a systematic review and meta-analysis to find the possible association of HScore parameters with severity in COVID-19 patients.
Methods: A systematic search was performed in Medline via PubMed, EMBASE, and Cochrane databases using all HScore and COVID-19 keywords. The studies were all from 2020, and the study language was limited to English. The records were screened based on inclusion/exclusion criteria. Random/fixed-effect models were employed for meta-analysis, based on the I2 index of parameters. The pooled mean differences were estimated for continuous parameters. The pooled odds-ratio was estimated for fever. The level of significance was set at 0.05.
Results: Eighteen studies (comprising 2459 patients) out of 26151 screened studies were included in this meta-analysis. The results showed that the level of leukocyte, neutrophil, aspartate transaminase (AST), ferritin, and fibrinogen were significantly higher in sCOVID-19 patients than in non-severe ones. Significant lower levels of lymphocyte, platelet, and hemoglobin were also found in sCOVID-19 patients than non-severe patients. Fever was nearly associated with two times increased odds of sCOVID-19 (P=0.051).
Conclusion: Lymphopenia, thrombocytopenia, hypohemoglobinemia, hyperferritinemia, high levels of AST, and fever are common features of both sCOVID-19 and HLH. However, the leukocytosis, neutrophilia, and hyperfibrinogenemia found in sCOVID-19 are in contrast with HScore. Conclusively, HScore parameters could be risk factors for sCOVID-19. However, some parameters’ roles are contradictory, suggesting the need for further investigation and a new way of HScore interpretation in sCOVID-19 patients.
A preprint of this study was published at https://www.researchsquare.com/article/rs-54490/v2.
کلیدواژه‌ها
COVID-19؛ Hemophagocytic lymphohistiocytosis؛ Systematic review؛ Meta-analysis
سایر فایل های مرتبط با مقاله
مراجع
  1. Organization WH. World Health Organization coronavirus disease (COVID-19) dashboard. World Health Organization. 2020.
  2. Skevaki C, Fragkou PC, Cheng C, Xie M, Renz H. Laboratory characteristics of patients infected with the novel SARS-CoV-2 virus. J Infect. 2020;81:205-12. doi: 10.1016/j.jinf.2020.06.039. PubMed PMID: 32579986; PubMed Central PMCID: PMCPMC7306198.
  3. Song P, Zhao L, Li X, Su J, Jiang Z, Song B, et al. Interpretation of TCM part in diagnosis and treatment protocol for COVID-19 (trial version 7). J Tradit Chin Med. 2020;40:497-508.
  4. Yang X, Yu Y, Xu J, Shu H, Xia J, Liu H, et al. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. Lancet Respir Med. 2020;8:475-81. doi: 10.1016/S2213-2600(20)30079-5. PubMed PMID: 32105632; PubMed Central PMCID: PMCPMC7102538.
  5. Khorramdelazad H, Kazemi MH, Najafi A, Keykhaee M, Zolfaghari Emameh R, Falak R. Immunopathological similarities between COVID-19 and influenza: Investigating the consequences of Co-infection. Microb Pathog. 2021;152:104554. doi: 10.1016/j.micpath.2020.104554. PubMed PMID: 33157216; PubMed Central PMCID: PMCPMC7607235.
  6. Clark KEN, Nevin WD, Mahungu T, Lachmann H, Singh A. Assessment of the Haemophagocytic lymphohistiocytosis HScore in patients with COVID-19. Clin Infect Dis. 2020. doi: 10.1093/cid/ciaa1463. PubMed PMID: 32985664; PubMed Central PMCID: PMCPMC7543356.
  7. Thomas BJ, Porritt RA, Hertzog PJ, Bardin PG, Tate MD. Glucocorticosteroids enhance replication of respiratory viruses: effect of adjuvant interferon. Sci Rep. 2014;4:7176. doi: 10.1038/srep07176. PubMed PMID: 25417801; PubMed Central PMCID: PMCPMC5384105.
  8. Ritchie AI, Singanayagam A. Immunosuppression for hyperinflammation in COVID-19: a double-edged sword? Lancet. 2020;395:1111. doi: 10.1016/S0140-6736(20)30691-7. PubMed PMID: 32220278; PubMed Central PMCID: PMCPMC7138169.
  9. Mehta P, McAuley DF, Brown M, Sanchez E, Tattersall RS, Manson JJ, et al. COVID-19: consider cytokine storm syndromes and immunosuppression. Lancet. 2020;395:1033-4. doi: 10.1016/S0140-6736(20)30628-0. PubMed PMID: 32192578; PubMed Central PMCID: PMCPMC7270045.
  10. Filipovich AH. Hemophagocytic lymphohistiocytosis (HLH) and related disorders. Hematology Am Soc Hematol Educ Program. 2009:127-31. doi: 10.1182/asheducation-2009.1.127. PubMed PMID: 20008190.
  11. Fardet L, Galicier L, Lambotte O, Marzac C, Aumont C, Chahwan D, et al. Development and validation of the HScore, a score for the diagnosis of reactive hemophagocytic syndrome. Arthritis Rheumatol. 2014;66:2613-20. doi: 10.1002/art.38690. PubMed PMID: 24782338.
  12. Prilutskiy A, Kritselis M, Shevtsov A, Yambayev I, Vadlamudi C, Zhao Q, et al. SARS-CoV-2 Infection-Associated Hemophagocytic Lymphohistiocytosis. Am J Clin Pathol. 2020;154:466-74. doi: 10.1093/ajcp/aqaa124. PubMed PMID: 32681166; PubMed Central PMCID: PMCPMC7454285.
  13. Faguer S, Del Bello A, Abravanel F, Nicolau-Travers ML, Kamar N. Tocilizumab for Hemophagocytic Syndrome in a Kidney Transplant Recipient With COVID-19. Ann Intern Med. 2020;173:501-3. doi: 10.7326/L20-0419. PubMed PMID: 32432518; PubMed Central PMCID: PMCPMC7505098.
  14. Sharif K, Vieira Borba V, Zandman-Goddard G, Shoenfeld Y. Eppur Si Muove: ferritin is essential in modulating inflammation. Clin Exp Immunol. 2018;191:149-50. doi: 10.1111/cei.13069. PubMed PMID: 29023673; PubMed Central PMCID: PMCPMC5758369.
  15. Rosario C, Zandman-Goddard G, Meyron-Holtz EG, D’Cruz DP, Shoenfeld Y. The hyperferritinemic syndrome: macrophage activation syndrome, Still’s disease, septic shock and catastrophic antiphospholipid syndrome. BMC Med. 2013;11:185. doi: 10.1186/1741-7015-11-185. PubMed PMID: 23968282; PubMed Central PMCID: PMCPMC3751883.
  16. Wu C, Chen X, Cai Y, Xia J, Zhou X, Xu S, et al. Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China. JAMA Intern Med. 2020;180:934-43. doi: 10.1001/jamainternmed.2020.0994. PubMed PMID: 32167524; PubMed Central PMCID: PMCPMC7070509.
  17. Bracaglia C, Prencipe G, De Benedetti F. Macrophage Activation Syndrome: different mechanisms leading to a one clinical syndrome. Pediatr Rheumatol Online J. 2017;15:5. doi: 10.1186/s12969-016-0130-4. PubMed PMID: 28095869; PubMed Central PMCID: PMCPMC5240371.
  18. Debliquis A, Harzallah I, Mootien JY, Poidevin A, Labro G, Mejri A, et al. Haemophagocytosis in bone marrow aspirates in patients with COVID-19. Br J Haematol. 2020;190:e70-e3. doi: 10.1111/bjh.16860. PubMed PMID: 32529634; PubMed Central PMCID: PMCPMC7307071.
  19. Takami A. Possible role of low-dose etoposide therapy for hemophagocytic lymphohistiocytosis by COVID-19. Int J Hematol. 2020;112:122-4. doi: 10.1007/s12185-020-02888-9. PubMed PMID: 32399895; PubMed Central PMCID: PMCPMC7216850.
  20. Loscocco GG. Secondary hemophagocytic lymphohistiocytosis, HScore and COVID-19. Int J Hematol. 2020;112:125-6. doi: 10.1007/s12185-020-02895-w. PubMed PMID: 32474804; PubMed Central PMCID: PMCPMC7261214.
  21. Leverenz DL, Tarrant TK. Is the HScore useful in COVID-19? Lancet. 2020;395:e83. doi: 10.1016/S0140-6736(20)31057-6. PubMed PMID: 32423585; PubMed Central PMCID: PMCPMC7200125.
  22. Wood H, Jones JR, Hui K, Mare T, Pirani T, Galloway J, et al. Secondary HLH is uncommon in severe COVID-19. Br J Haematol. 2020;190:e283-e5. doi: 10.1111/bjh.16934. PubMed PMID: 32526046; PubMed Central PMCID: PMCPMC7307063.
  23. Moher D, Shamseer L, Clarke M, Ghersi D, Liberati A, Petticrew M, et al. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Syst Rev. 2015;4:1-9. doi: 10.1186/2046-4053-4-1. PubMed PMID: 25554246; PubMed Central PMCID: PMCPMC4320440.
  24. Downes MJ, Brennan ML, Williams HC, Dean RS. Development of a critical appraisal tool to assess the quality of cross-sectional studies (AXIS). BMJ Open. 2016;6:e011458. doi: 10.1136/bmjopen-2016-011458. PubMed PMID: 27932337; PubMed Central PMCID: PMCPMC5168618.
  25. Luo D, Wan X, Liu J, Tong T. Optimally estimating the sample mean from the sample size, median, mid-range, and/or mid-quartile range. Stat Methods Med Res. 2018;27:1785-805. doi: 10.1177/0962280216669183. PubMed PMID: 27683581.
  26. Wan X, Wang W, Liu J, Tong T. Estimating the sample mean and standard deviation from the sample size, median, range and/or interquartile range. BMC Med Res Methodol. 2014;14:135. doi: 10.1186/1471-2288-14-135. PubMed PMID: 25524443; PubMed Central PMCID: PMCPMC4383202.
  27. Zhou Y, Han T, Chen J, Hou C, Hua L, He S, et al. Clinical and Autoimmune Characteristics of Severe and Critical Cases of COVID-19. Clin Transl Sci. 2020;13:1077-86. doi: 10.1111/cts.12805. PubMed PMID: 32315487; PubMed Central PMCID: PMCPMC7264560.
  28. Zhao XY, Xu XX, Yin HS, Hu QM, Xiong T, Tang YY, et al. Clinical characteristics of patients with 2019 coronavirus disease in a non-Wuhan area of Hubei Province, China: a retrospective study. BMC Infect Dis. 2020;20:311. doi: 10.1186/s12879-020-05010-w. PubMed PMID: 32345226; PubMed Central PMCID: PMCPMC7188494.
  29. Pereira MR, Mohan S, Cohen DJ, Husain SA, Dube GK, Ratner LE, et al. COVID-19 in solid organ transplant recipients: Initial report from the US epicenter. Am J Transplant. 2020;20:1800-8. doi: 10.1111/ajt.15941. PubMed PMID: 32330343; PubMed Central PMCID: PMCPMC7264777.
  30. Chen Q, Zheng Z, Zhang C, Zhang X, Wu H, Wang J, et al. Clinical characteristics of 145 patients with corona virus disease 2019 (COVID-19) in Taizhou, Zhejiang, China. Infection. 2020;48:543-51. doi: 10.1007/s15010-020-01432-5. PubMed PMID: 32342479; PubMed Central PMCID: PMCPMC7186187.
  31. Aggarwal S, Garcia-Telles N, Aggarwal G, Lavie C, Lippi G, Henry BM. Clinical features, laboratory characteristics, and outcomes of patients hospitalized with coronavirus disease 2019 (COVID-19): Early report from the United States. Diagnosis (Berl). 2020;7:91-6. doi: 10.1515/dx-2020-0046. PubMed PMID: 32352401.
  32. Zou Y, Guo H, Zhang Y, Zhang Z, Liu Y, Wang J, et al. Analysis of coagulation parameters in patients with COVID-19 in Shanghai, China. Biosci Trends. 2020;14:285-9. doi: 10.5582/bst.2020.03086. PubMed PMID: 32350161.
  33. Zhang Y, Zheng L, Liu L, Zhao M, Xiao J, Zhao Q. Liver impairment in COVID-19 patients: A retrospective analysis of 115 cases from a single centre in Wuhan city, China. Liver Int. 2020;40:2095-103. doi: 10.1111/liv.14455. PubMed PMID: 32239796.
  34. Young BE, Ong SWX, Kalimuddin S, Low JG, Tan SY, Loh J, et al. Epidemiologic Features and Clinical Course of Patients Infected With SARS-CoV-2 in Singapore. JAMA. 2020;323:1488-94. doi: 10.1001/jama.2020.3204. PubMed PMID: 32125362; PubMed Central PMCID: PMCPMC7054855.
  35. Pei G, Zhang Z, Peng J, Liu L, Zhang C, Yu C, et al. Renal Involvement and Early Prognosis in Patients with COVID-19 Pneumonia. J Am Soc Nephrol. 2020;31:1157-65. doi: 10.1681/ASN.2020030276. PubMed PMID: 32345702; PubMed Central PMCID: PMCPMC7269350.
  36. Liu J, Li S, Liu J, Liang B, Wang X, Wang H, et al. Longitudinal characteristics of lymphocyte responses and cytokine profiles in the peripheral blood of SARS-CoV-2 infected patients. EBioMedicine. 2020;55:102763. doi: 10.1016/j.ebiom.2020.102763. PubMed PMID: 32361250; PubMed Central PMCID: PMCPMC7165294.
  37. Feng Y, Ling Y, Bai T, Xie Y, Huang J, Li J, et al. COVID-19 with Different Severities: A Multicenter Study of Clinical Features. Am J Respir Crit Care Med. 2020;201:1380-8. doi: 10.1164/rccm.202002-0445OC. PubMed PMID: 32275452; PubMed Central PMCID: PMCPMC7258639.
  38. Zheng Y, Zhang Y, Chi H, Chen S, Peng M, Luo L, et al. The hemocyte counts as a potential biomarker for predicting disease progression in COVID-19: a retrospective study. Clin Chem Lab Med. 2020;58:1106-15. doi: 10.1515/cclm-2020-0377. PubMed PMID: 32352397.
  39. Yao Q, Wang P, Wang X, Qie G, Meng M, Tong X, et al. A retrospective study of risk factors for severe acute respiratory syndrome coronavirus 2 infections in hospitalized adult patients. Pol Arch Intern Med. 2020;130:390-9. doi: 10.20452/pamw.15312. PubMed PMID: 32329978.
  40. Wang F, Hou H, Luo Y, Tang G, Wu S, Huang M, et al. The laboratory tests and host immunity of COVID-19 patients with different severity of illness. JCI Insight. 2020;5. doi: 10.1172/jci.insight.137799. PubMed PMID: 32324595; PubMed Central PMCID: PMCPMC7259533.
  41. Medetalibeyoglu A, Senkal N, Capar G, Kose M, Tukek T. Characteristics of the initial patients hospitalized for COVID-19: a single-center report. Turk J Med Sci. 2020;50:1436-9. doi: 10.3906/sag-2004-98. PubMed PMID: 32490641; PubMed Central PMCID: PMCPMC7491264.
  42. Li X, Xu S, Yu M, Wang K, Tao Y, Zhou Y, et al. Risk factors for severity and mortality in adult COVID-19 inpatients in Wuhan. J Allergy Clin Immunol. 2020;146:110-8. doi: 10.1016/j.jaci.2020.04.006. PubMed PMID: 32294485; PubMed Central PMCID: PMCPMC7152876.
  43. Di Micco P, Russo V, Carannante N, Imparato M, Rodolfi S, Cardillo G, et al. Clotting Factors in COVID-19: Epidemiological Association and Prognostic Values in Different Clinical Presentations in an Italian Cohort. J Clin Med. 2020;9. doi: 10.3390/jcm9051371. PubMed PMID: 32392741; PubMed Central PMCID: PMCPMC7290348.
  44. Chen G, Wu D, Guo W, Cao Y, Huang D, Wang H, et al. Clinical and immunological features of severe and moderate coronavirus disease 2019. J Clin Invest. 2020;130:2620-9. doi: 10.1172/JCI137244. PubMed PMID: 32217835; PubMed Central PMCID: PMCPMC7190990.
  45. Fagerland MW. Evidence-based medicine and systematic reviews. Research in medical and biological sciences. 2015:431-61. doi: 10.1016/B978-0-12-799943-2.00012-4.
  46. Zhang ZL, Hou YL, Li DT, Li FZ. Laboratory findings of COVID-19: a systematic review and meta-analysis. Scand J Clin Lab Invest. 2020;80:441-7. doi: 10.1080/00365513.2020.1768587. PubMed PMID: 32449374; PubMed Central PMCID: PMCPMC7256350.
  47. Rodriguez-Morales AJ, Cardona-Ospina JA, Gutierrez-Ocampo E, Villamizar-Pena R, Holguin-Rivera Y, Escalera-Antezana JP, et al. Clinical, laboratory and imaging features of COVID-19: A systematic review and meta-analysis. Travel Med Infect Dis. 2020;34:101623. doi: 10.1016/j.tmaid.2020.101623. PubMed PMID: 32179124; PubMed Central PMCID: PMCPMC7102608.
  48. Henry BM, de Oliveira MHS, Benoit S, Plebani M, Lippi G. Hematologic, biochemical and immune biomarker abnormalities associated with severe illness and mortality in coronavirus disease 2019 (COVID-19): a meta-analysis. Clin Chem Lab Med. 2020;58:1021-8. doi: 10.1515/cclm-2020-0369. PubMed PMID: 32286245.
  49. Sanyaolu A, Okorie C, Marinkovic A, Patidar R, Younis K, Desai P, et al. Comorbidity and its Impact on Patients with COVID-19. SN Compr Clin Med. 2020:1-8. doi: 10.1007/s42399-020-00363-4. PubMed PMID: 32838147; PubMed Central PMCID: PMCPMC7314621.
  50. Wang B, Li R, Lu Z, Huang Y. Does comorbidity increase the risk of patients with COVID-19: evidence from meta-analysis. Aging (Albany NY). 2020;12:6049-57. doi: 10.18632/aging.103000. PubMed PMID: 32267833; PubMed Central PMCID: PMCPMC7185114.
  51. Jakhmola S, Indari O, Baral B, Kashyap D, Varshney N, Das A, et al. Comorbidity Assessment Is Essential During COVID-19 Treatment. Front Physiol. 2020;11:984. doi: 10.3389/fphys.2020.00984. PubMed PMID: 32903640; PubMed Central PMCID: PMCPMC7438844.
  52. Higgins JP, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, et al. Cochrane handbook for systematic reviews of interventions. New Jersey: John Wiley and Sons; 2019. doi: 10.1002/9781119536604.
  53. Zhao K, Li R, Wu X, Zhao Y, Wang T, Zheng Z, et al. Clinical features in 52 patients with COVID-19 who have increased leukocyte count: a retrospective analysis. Eur J Clin Microbiol Infect Dis. 2020;39:2279-87. doi: 10.1007/s10096-020-03976-8. PubMed PMID: 32651736; PubMed Central PMCID: PMCPMC7351641.
  54. Khartabil TA, Russcher H, van der Ven A, de Rijke YB. A summary of the diagnostic and prognostic value of hemocytometry markers in COVID-19 patients. Crit Rev Clin Lab Sci. 2020;57:415-31. doi: 10.1080/10408363.2020.1774736. PubMed PMID: 32568604.
  55. Lippi G, Plebani M, Henry BM. Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: A meta-analysis. Clin Chim Acta. 2020;506:145-8. doi: 10.1016/j.cca.2020.03.022. PubMed PMID: 32178975; PubMed Central PMCID: PMCPMC7102663.
  56. Huang I, Pranata R. Lymphopenia in severe coronavirus disease-2019 (COVID-19): systematic review and meta-analysis. J Intensive Care. 2020;8:36. doi: 10.1186/s40560-020-00453-4. PubMed PMID: 32483488; PubMed Central PMCID: PMCPMC7245646.
  57. Fu L, Wang B, Yuan T, Chen X, Ao Y, Fitzpatrick T, et al. Clinical characteristics of coronavirus disease 2019 (COVID-19) in China: A systematic review and meta-analysis. J Infect. 2020;80:656-65. doi: 10.1016/j.jinf.2020.03.041. PubMed PMID: 32283155; PubMed Central PMCID: PMCPMC7151416.
  58. Lin J, Yan H, Chen H, He C, Lin C, He H, et al. COVID-19 and coagulation dysfunction in adults: A systematic review and meta-analysis. J Med Virol. 2021;93:934-44. doi: 10.1002/jmv.26346. PubMed PMID: 32706426; PubMed Central PMCID: PMCPMC7405098.
  59. Jiang SQ, Huang QF, Xie WM, Lv C, Quan XQ. The association between severe COVID-19 and low platelet count: evidence from 31 observational studies involving 7613 participants. Br J Haematol. 2020;190:e29-e33. doi: 10.1111/bjh.16817. PubMed PMID: 32420607.
  60. Beutler E, Waalen J. The definition of anemia: what is the lower limit of normal of the blood hemoglobin concentration? Blood. 2006;107:1747-50. doi: 10.1182/blood-2005-07-3046. PubMed PMID: 16189263; PubMed Central PMCID: PMCPMC1895695.
  61. Taneri PE, Gomez-Ochoa SA, Llanaj E, Raguindin PF, Rojas LZ, Roa-Diaz ZM, et al. Anemia and iron metabolism in COVID-19: a systematic review and meta-analysis. Eur J Epidemiol. 2020;35:763-73. doi: 10.1007/s10654-020-00678-5. PubMed PMID: 32816244; PubMed Central PMCID: PMCPMC7438401.
  62. Debaugnies F, Mahadeb B, Ferster A, Meuleman N, Rozen L, Demulder A, et al. Performances of the H-Score for Diagnosis of Hemophagocytic Lymphohistiocytosis in Adult and Pediatric Patients. Am J Clin Pathol. 2016;145:862-70. doi: 10.1093/ajcp/aqw076. PubMed PMID: 27298397.
  63. Shi L, Wang Y, Wang Y, Duan G, Yang H. Dyspnea rather than fever is a risk factor for predicting mortality in patients with COVID-19. J Infect. 2020;81:647-79. doi: 10.1016/j.jinf.2020.05.013. PubMed PMID: 32417316; PubMed Central PMCID: PMCPMC7228739.
  64. Palmer WC, Zaver HB, Ghoz HM. How I Approach Patients With Elevated Serum Ferritin. Am J Gastroenterol. 2020;115:1353-5. doi: 10.14309/ajg.0000000000000700. PubMed PMID: 32530827.
  65. Huang I, Pranata R, Lim MA, Oehadian A, Alisjahbana B. C-reactive protein, procalcitonin, D-dimer, and ferritin in severe coronavirus disease-2019: a meta-analysis. Ther Adv Respir Dis. 2020;14:1753466620937175. doi: 10.1177/1753466620937175. PubMed PMID: 32615866; PubMed Central PMCID: PMCPMC7336828.
  66. Bode JG, Albrecht U, Haussinger D, Heinrich PC, Schaper F. Hepatic acute phase proteins--regulation by IL-6- and IL-1-type cytokines involving STAT3 and its crosstalk with NF-kappaB-dependent signaling. Eur J Cell Biol. 2012;91:496-505. doi: 10.1016/j.ejcb.2011.09.008. PubMed PMID: 22093287.
  67. Castell JV, Gomez-Lechon MJ, David M, Andus T, Geiger T, Trullenque R, et al. Interleukin-6 is the major regulator of acute phase protein synthesis in adult human hepatocytes. FEBS Lett. 1989;242:237-9. doi: 10.1016/0014-5793(89)80476-4. PubMed PMID: 2464504.
  68. Parohan M, Yaghoubi S, Seraji A. Liver injury is associated with severe coronavirus disease 2019 (COVID-19) infection: A systematic review and meta-analysis of retrospective studies. Hepatol Res. 2020;50:924-35. doi: 10.1111/hepr.13510. PubMed PMID: 32386449; PubMed Central PMCID: PMCPMC7273097.
  69. Henry B, Cheruiyot I, Vikse J, Mutua V, Kipkorir V, Benoit J, et al. Lymphopenia and neutrophilia at admission predicts severity and mortality in patients with COVID-19: a meta-analysis. Acta Biomed. 2020;91:e2020008. doi: 10.23750/abm.v91i3.10217. PubMed PMID: 32921706; PubMed Central PMCID: PMCPMC7716963.
  70. Zhu J, Pang J, Ji P, Zhong Z, Li H, Li B, et al. Coagulation dysfunction is associated with severity of COVID-19: A meta-analysis. J Med Virol. 2021;93:962-72. doi: 10.1002/jmv.26336. PubMed PMID: 32706396; PubMed Central PMCID: PMCPMC7404826.
آمار
تعداد مشاهده مقاله: 3,602
تعداد دریافت فایل اصل مقاله: 3,966


سامانه مدیریت نشریات علمی. قدرت گرفته از سیناوب