Rezaei, Mostafa, Mazloomi, seyed mohammad, Mohammadi, Fatemeh, Shahrokhi sardo, Maryam. (1400). Does vitamin E improve the smokers' salivary antioxidant status?. سامانه مدیریت نشریات علمی, 7(3), 161-168. doi: 10.30476/tips.2021.91519.1101
Mostafa Rezaei; seyed mohammad Mazloomi; Fatemeh Mohammadi; Maryam Shahrokhi sardo. "Does vitamin E improve the smokers' salivary antioxidant status?". سامانه مدیریت نشریات علمی, 7, 3, 1400, 161-168. doi: 10.30476/tips.2021.91519.1101
Rezaei, Mostafa, Mazloomi, seyed mohammad, Mohammadi, Fatemeh, Shahrokhi sardo, Maryam. (1400). 'Does vitamin E improve the smokers' salivary antioxidant status?', سامانه مدیریت نشریات علمی, 7(3), pp. 161-168. doi: 10.30476/tips.2021.91519.1101
Rezaei, Mostafa, Mazloomi, seyed mohammad, Mohammadi, Fatemeh, Shahrokhi sardo, Maryam. Does vitamin E improve the smokers' salivary antioxidant status?. سامانه مدیریت نشریات علمی, 1400; 7(3): 161-168. doi: 10.30476/tips.2021.91519.1101

Does vitamin E improve the smokers' salivary antioxidant status?

Trends in Pharmaceutical Sciences and Technologies
مقاله 3، دوره 7، شماره 3، پاییز 2021، صفحه 161-168    اصل مقاله (418.8 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.30476/tips.2021.91519.1101
نویسندگان
Mostafa Rezaei1؛ seyed mohammad Mazloomi2؛ Fatemeh Mohammadi3؛ Maryam Shahrokhi sardo* 4
1Assistant professor , Department of Oral and Maxillofacial Medicine, School Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran
2Associate professor, Research Center and School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran
3Graduate student, Shiraz University of Medical Sciences, Shiraz, Iran
4undergraduate student,dtudent research committee,school of dentistry ,shiraz university of medical science
چکیده
Background: Vitamin E is known as a preventive or therapeutic antioxidant that improves the total antioxidant capacity (TAC) of saliva in individuals at risk of different oral cavity oxidative stresses. This study aimed to compare the effect of this vitamin on the salivary TAC between smokers and non-smokers.
Materials and Methods: In this single-blind crossover clinical trial, non-stimulated saliva samples were collected from smoker and nonsmoker participants (n=60 per group) at three stages (baseline and after the two interventional phases). They were divided into subgroups to receive daily vitamin E (200 IU) and placebo for three weeks alternatively in the first or second phase. The salivary TAC was measured via fluorescence recovery after photobleaching method. The TAC changes were calculated in each phase. Data were analyzed by using SPSS software through repeated measures ANOVA, independent sample t-test, and covariate test.
Results: The mean changes of TAC of smokers first receiving vitamin E and then placebo were 0.06±0.091 (U/mL) and 025.0±0.089 (U/mL), respectively (P=0.017). The non-smokers' mean TAC changes were 0.059±0.13 versus 0.053±0.129, respectively, after taking vitamin E and placebo; being statistically insignificant (P=0.791).
Conclusion: Accordingly, vitamin E improved the salivary TAC in both non-smokers and smokers.
کلیدواژه‌ها
saliva؛ smoking؛ total antioxidant capacity؛ vitamin E
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