Evaluation of Thermal Properties of Ferromagnetic Core for Treatment of Solid Tumors by Electromagnetic Induction Hyperthermia | ||
| Journal of Biomedical Physics and Engineering | ||
| مقاله 6، دوره 13، شماره 6، اسفند 2023، صفحه 543-554 اصل مقاله (1.49 M) | ||
| نوع مقاله: Original Research | ||
| شناسه دیجیتال (DOI): 10.31661/jbpe.v0i0.2101-1261 | ||
| نویسندگان | ||
| Elham Mohagheghpour* 1؛ Shahab Sheibani1؛ Reza Saber2؛ Mohammad Soliemanpoor3؛ Saeed Sarkar2؛ Amirhossein Nezamdust4 | ||
| 1Radiation Applications Research School, Nuclear Science and Technology Research Institute, Tehran, Iran | ||
| 2Research Center for Science and Technology in Medicine, Tehran University of Medical Sciences, Tehran, Iran | ||
| 3Department of Energy Engineering, Sharif University of Technology, Tehran, Iran | ||
| 4Department of Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran | ||
| چکیده | ||
| Background: Electromagnetic induction hyperthermia is a promising method to treat the deep-seated tumors such as brain and prostatic tumors. This technique is performed using the induction of electromagnetic waves in the ferromagnetic cores implanted at the solid tumor. Objective: This study aims at determining the conditions of the optimal thermal distribution in the different frequencies before performing the in vitro cellular study. Material and Methods: In this experimental study, the i-Cu alloy (70.4-29.6; wt%) was prepared and characterized and then the parameters, affecting the amount of induction heating in the ferromagnetic core, were investigated. Self-regulating cores in 1, 3, 6, and 9 arrangements in the water phantom with a volume of 2 cm3 were used as a replacement for solid tumor. Results: Inductively Coupled Plasma (ICP) analysis and Energy Dispersive X-ray Spectroscopy (EDS) show the uniformity of the alloy after 4 times remeling by vacuum arc remelting furnace. The Vibrating Sample Magnetometer (VSM) shows that the Curie temperature (TC) of the ferromagnetic core is less than 50 °C. Temperature profile with a frequency of 100-400 kHz for 30 min, was extracted by infrared imaging camera, indicating the increase temperature in the range of 42 °C to 46 °C. Conclusion: The optimum conditions with used hyperthermia system are supplied in the frequency of 100 kHz, 200 kHz and 400 kHz with 6, 3 and 1 seeds, respectively. It is also possible to induce a temperature up to 50 °C by increasing the number of seeds at a constant frequency and power, or by increasing the applied frequency at a constant number of seeds. | ||
تازه های تحقیق | ||
Elham Mohagheghpour (Google Scholar) | ||
| کلیدواژهها | ||
| Hyperthermia؛ Electromagnetic Fields؛ Ni-Cu Ferromagnetic Core؛ Solid Tumor؛ Water Phantom؛ Alloys | ||
| مراجع | ||
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