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Numasaki, Muneo, Ito, Koyu. (1400). VEGF-A, HGF and bFGF are involved in IL-17A-mediated migration and capillary-like vessel formation of vascular endothelial cells. سامانه مدیریت نشریات علمی, 18(2), 103-110. doi: 10.22034/iji.2021.91214.2059
Muneo Numasaki; Koyu Ito. "VEGF-A, HGF and bFGF are involved in IL-17A-mediated migration and capillary-like vessel formation of vascular endothelial cells". سامانه مدیریت نشریات علمی, 18, 2, 1400, 103-110. doi: 10.22034/iji.2021.91214.2059
Numasaki, Muneo, Ito, Koyu. (1400). 'VEGF-A, HGF and bFGF are involved in IL-17A-mediated migration and capillary-like vessel formation of vascular endothelial cells', سامانه مدیریت نشریات علمی, 18(2), pp. 103-110. doi: 10.22034/iji.2021.91214.2059
Numasaki, Muneo, Ito, Koyu. VEGF-A, HGF and bFGF are involved in IL-17A-mediated migration and capillary-like vessel formation of vascular endothelial cells. سامانه مدیریت نشریات علمی, 1400; 18(2): 103-110. doi: 10.22034/iji.2021.91214.2059

VEGF-A, HGF and bFGF are involved in IL-17A-mediated migration and capillary-like vessel formation of vascular endothelial cells

Iranian Journal of Immunology
مقاله 2، دوره 18، شماره 2، شهریور 2021، صفحه 103-110    اصل مقاله (1.63 M)
نوع مقاله: Short Paper
شناسه دیجیتال (DOI): 10.22034/iji.2021.91214.2059
نویسندگان
Muneo Numasaki* 1؛ Koyu Ito2
1Laboratory of Clinical Science and Biomedicine, Faculty of Pharmaceutical Sciences, Josai University, Sakado, Japan
2Department of Immunology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
چکیده
Background: Interleukin (IL)-17A possesses biological activities to promote vascular endothelial cell migration and microvessel development. Objective: To clarify which angiogenic factors are involved in IL-17A-modified angiogenesis-related functions of vascular endothelial cell migration and microtube development or not. Methods: The potential contribution of various angiogenic stimulators to in vitro angiogenic activities of IL-17A was assessed with both modified Boyden Chemotaxicell chamber assay and in vitro angiogenesis assay. Results: The addition of a neutralizing antibody (Ab) for hepatocyte growth factor (HGF), basic fibroblast growth factor (bFGF) or vascular endothelial growth factor (VEGF)-A to the upper and lower compartments in a modified Boyden Chemotaxicell chamber significantly attenuated human dermal microvascular endothelial cell (HMVEC) migration elicited by IL-17A. Moreover, IL-17A-induced capillary-like microvessel development in human umbilical vein endothelial cell (HUVEC) and human dermal fibroblast (HDF) co-culture system was significantly impaired by a neutralizing Ab against HGF, bFGF, VEGF-A, cysteine-x-cysteine ligand 8 (CXCL8)/IL-8 or cysteine-x-cysteine (CXC) chemokine receptor (CXCR)-2. Conclusion: Our findings demonstrate the involvement of HGF, bFGF, VEGF-A and/or CXCL8/IL-8, to various degrees, in migration and microvessel development of vascular endothelial cells mediated by IL-17A.
کلیدواژه‌ها
Angiogenesis؛ IL-17A؛ Migration؛ Tube formation؛ Vascular Endothelial Cells
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