LinkedIn

 آمار

تعداد نشریات20
تعداد شماره‌ها1,149
تعداد مقالات10,519
تعداد مشاهده مقاله45,427,408
تعداد دریافت فایل اصل مقاله11,296,921
Mashhadi-Abbas, Fatemeh, Fayazi_Boroujeni, Masoume, Alizadeh, Akram, Namdari, Mahshid, Mirzaei, Seyed Abbas. (1400). Immunoexpression of C4 Binding Protein in Oral Leukoplakia and Oral Squamous Cell Carcinoma. سامانه مدیریت نشریات علمی, 18(2), 95-102. doi: 10.22034/iji.2021.87031.1782
Fatemeh Mashhadi-Abbas; Masoume Fayazi_Boroujeni; Akram Alizadeh; Mahshid Namdari; Seyed Abbas Mirzaei. "Immunoexpression of C4 Binding Protein in Oral Leukoplakia and Oral Squamous Cell Carcinoma". سامانه مدیریت نشریات علمی, 18, 2, 1400, 95-102. doi: 10.22034/iji.2021.87031.1782
Mashhadi-Abbas, Fatemeh, Fayazi_Boroujeni, Masoume, Alizadeh, Akram, Namdari, Mahshid, Mirzaei, Seyed Abbas. (1400). 'Immunoexpression of C4 Binding Protein in Oral Leukoplakia and Oral Squamous Cell Carcinoma', سامانه مدیریت نشریات علمی, 18(2), pp. 95-102. doi: 10.22034/iji.2021.87031.1782
Mashhadi-Abbas, Fatemeh, Fayazi_Boroujeni, Masoume, Alizadeh, Akram, Namdari, Mahshid, Mirzaei, Seyed Abbas. Immunoexpression of C4 Binding Protein in Oral Leukoplakia and Oral Squamous Cell Carcinoma. سامانه مدیریت نشریات علمی, 1400; 18(2): 95-102. doi: 10.22034/iji.2021.87031.1782

Immunoexpression of C4 Binding Protein in Oral Leukoplakia and Oral Squamous Cell Carcinoma

Iranian Journal of Immunology
مقاله 1، دوره 18، شماره 2، شهریور 2021، صفحه 95-102    اصل مقاله (2.08 M)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22034/iji.2021.87031.1782
نویسندگان
Fatemeh Mashhadi-Abbas1، 2؛ Masoume Fayazi_Boroujeni* 1؛ Akram Alizadeh3؛ Mahshid Namdari4؛ Seyed Abbas Mirzaei5
1Oral and Maxillofacial Pathology Department, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2Dental Research Center, Research Institute of Dental School, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3Cellular and molecular research center, basic health sciences institute, Shahrekord University of Medical Sciences, Shahrekord, Iran
4Community Oral Health Department, Shahid Beheshti University of Medical Sciences, Tehran, Iran
5School of Advanced Technologies, Shahrekord University of Medical Sciences, Shahrekord, Iran
چکیده
Background: The immune evasion of dysplastic cells plays an important role in suppressing the immune response and progression of malignancy. The role of the complement inhibitors in the development of oral epithelial dysplastic lesions and squamous cell carcinoma (SCC) is still unclear. Objective: This study aimed to assess the expression of C4 binding protein (C4BP) as a complement inhibitor in oral squamous cell carcinoma and leukoplakia. Methods: In this study, 94 samples were classified into four groups: leukoplakia with mild to moderate dysplasia, leukoplakia with severe dysplasia or carcinoma in situ, early invasive SCC, and invasive SCC. The expression of C4BP marker was evaluated by immunohistochemistry (IHC) and real-time PCR. The results were analyzed by the Kruskal-Wallis, Bonferroni adjusted Dunn’s multiple comparison, and one-way ANOVA tests. Results: The results of IHC revealed the expression patterns of C4BP in oral dysplasia and SCC, and indicated that the C4BP expression was not significantly different between different histopathological grades in epithelial cells and vessels (P=0.157 and P=0.123, respectively) but, it was significantly different in fibroblasts and lymphocytes (P=0.017 and P=0.043, respectively). The real-time PCR showed a significant correlation between the dysplasia grade and expression of C4BP (p <0.05). Conclusion: According to the results, C4BP is expressed in the cancerous tissue by the tumor cells and their surrounding stroma. In addition, upregulation of the C4BP gene as an inhibitor of the complement system is a possible strategy adopted by the tumor cells to evade the immune system.
کلیدواژه‌ها
Carcinoma in Situ؛ Complement C4b Binding Protein, Head and Neck Squamous Cell Carcinoma
آمار
تعداد مشاهده مقاله: 1,321
تعداد دریافت فایل اصل مقاله: 960


سامانه مدیریت نشریات علمی. قدرت گرفته از سیناوب