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Bahrayni Toosi, Mohammad Taghi, Kasiri, Afsaneh, Torabinejad, Sepehr, Soleymanifard, Shokouhozaman, Sankian, Mojtaba, Aledavood, Seyed Amir, Hosseini Shamili, Fazileh, Lavi, Fahimeh. (1402). Preliminary Results of the Effects of Localized High-Dose Radiotherapy Combined with Total Body Low-Dose Irradiation on Tumor Growth and Stimulating the Immune System in Tumor-Bearing Mice. سامانه مدیریت نشریات علمی, 13(4), 323-332. doi: 10.31661/jbpe.v0i0.2009-1179
Mohammad Taghi Bahrayni Toosi; Afsaneh Kasiri; Sepehr Torabinejad; Shokouhozaman Soleymanifard; Mojtaba Sankian; Seyed Amir Aledavood; Fazileh Hosseini Shamili; Fahimeh Lavi. "Preliminary Results of the Effects of Localized High-Dose Radiotherapy Combined with Total Body Low-Dose Irradiation on Tumor Growth and Stimulating the Immune System in Tumor-Bearing Mice". سامانه مدیریت نشریات علمی, 13, 4, 1402, 323-332. doi: 10.31661/jbpe.v0i0.2009-1179
Bahrayni Toosi, Mohammad Taghi, Kasiri, Afsaneh, Torabinejad, Sepehr, Soleymanifard, Shokouhozaman, Sankian, Mojtaba, Aledavood, Seyed Amir, Hosseini Shamili, Fazileh, Lavi, Fahimeh. (1402). 'Preliminary Results of the Effects of Localized High-Dose Radiotherapy Combined with Total Body Low-Dose Irradiation on Tumor Growth and Stimulating the Immune System in Tumor-Bearing Mice', سامانه مدیریت نشریات علمی, 13(4), pp. 323-332. doi: 10.31661/jbpe.v0i0.2009-1179
Bahrayni Toosi, Mohammad Taghi, Kasiri, Afsaneh, Torabinejad, Sepehr, Soleymanifard, Shokouhozaman, Sankian, Mojtaba, Aledavood, Seyed Amir, Hosseini Shamili, Fazileh, Lavi, Fahimeh. Preliminary Results of the Effects of Localized High-Dose Radiotherapy Combined with Total Body Low-Dose Irradiation on Tumor Growth and Stimulating the Immune System in Tumor-Bearing Mice. سامانه مدیریت نشریات علمی, 1402; 13(4): 323-332. doi: 10.31661/jbpe.v0i0.2009-1179

Preliminary Results of the Effects of Localized High-Dose Radiotherapy Combined with Total Body Low-Dose Irradiation on Tumor Growth and Stimulating the Immune System in Tumor-Bearing Mice

Journal of Biomedical Physics and Engineering
مقاله 4، دوره 13، شماره 4، آبان 2023، صفحه 323-332    اصل مقاله (1009.63 K)
نوع مقاله: Original Research
شناسه دیجیتال (DOI): 10.31661/jbpe.v0i0.2009-1179
نویسندگان
Mohammad Taghi Bahrayni Toosi1؛ Afsaneh Kasiri2؛ Sepehr Torabinejad3؛ Shokouhozaman Soleymanifard* 1؛ Mojtaba Sankian4؛ Seyed Amir Aledavood5؛ Fazileh Hosseini Shamili4؛ Fahimeh Lavi4
1Medical Physics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
2Department of Medical Physics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
3Department of Genetics, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran
4Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
5Cancer Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
چکیده
Background: The immune system plays an extensive role in eliminating tumor cells. On the other hand, low-dose irradiation stimulates the immune system.
Objective: The present study aimed to investigate the therapeutic outcomes of localized high-dose radiotherapy (LH) alone and combined with total body low-dose irradiation (TB).
Material and Methods: In this experimental study, B16F0 tumor cells were injected into the right flank of C57JL/6 mice. The mice were treated with LH alone (13 Gy X-rays to the tumor surface) (LH group) or combined with TB (85 mGy X-rays at the skin) (TB+LH group). Then the tumor volume, the mice’s lifespan, the number of lymphocytes extracted from the spleen, and interferon gamma (IFN-γ) production were measured.
Results: Reduced number of lymphocytes, compared to non-irradiated mice (control group), was observed in LH and TB+LH groups. However, the identical number of cultured lymphocytes produced a higher level of IFN-γ in irradiated groups. Comparing the irradiated groups, the number of lymphocytes and their IFN-γ production, tumor growth control, and the mice’s lifespan were statistically higher in TB+LH group. 
Conclusion: Observing a higher level of IFN-γ in TB+LH group compared to LH group indicates that low-dose radiation enhanced the stimulating effects of high-dose radiation on the immune system. It caused the mice in TB+LH group to have a more prolonged lifespan and a lower tumor growth rate. Therefore, it is worth our attention for future studies to investigate whether total body low-dose irradiation can be utilized before radiotherapy to enhance its efficiency.

تازه های تحقیق

Mohammad Taghi Bahrayni Toosi (Google Scholar)

Shokouhozaman Soleymanifard (Google Scholar)

کلیدواژه‌ها
Immune System؛ Radiotherapy؛ Whole-Body Irradiation؛ IFN-γ
سایر فایل های مرتبط با مقاله
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