LinkedIn

 آمار

تعداد نشریات20
تعداد شماره‌ها1,113
تعداد مقالات10,208
تعداد مشاهده مقاله40,782,826
تعداد دریافت فایل اصل مقاله8,806,327
Haddadi, Kaveh, Moradi, Siavash, Asadian, Leila, Montazer, Seyed Hosein, Hosseininejad, Seyed Mohammad, Golikhatir, Iraj, Abedian Kenari, Saeid, Alaee, Abdulrassol, Bozorgi, Farzad. (1400). Aldolase C Profiling in Serum after Mild Traumatic Brain Injury: A Prospective Cohort Study. سامانه مدیریت نشریات علمی, 47(1), 33-39. doi: 10.30476/ijms.2021.87692.1831
Kaveh Haddadi; Siavash Moradi; Leila Asadian; Seyed Hosein Montazer; Seyed Mohammad Hosseininejad; Iraj Golikhatir; Saeid Abedian Kenari; Abdulrassol Alaee; Farzad Bozorgi. "Aldolase C Profiling in Serum after Mild Traumatic Brain Injury: A Prospective Cohort Study". سامانه مدیریت نشریات علمی, 47, 1, 1400, 33-39. doi: 10.30476/ijms.2021.87692.1831
Haddadi, Kaveh, Moradi, Siavash, Asadian, Leila, Montazer, Seyed Hosein, Hosseininejad, Seyed Mohammad, Golikhatir, Iraj, Abedian Kenari, Saeid, Alaee, Abdulrassol, Bozorgi, Farzad. (1400). 'Aldolase C Profiling in Serum after Mild Traumatic Brain Injury: A Prospective Cohort Study', سامانه مدیریت نشریات علمی, 47(1), pp. 33-39. doi: 10.30476/ijms.2021.87692.1831
Haddadi, Kaveh, Moradi, Siavash, Asadian, Leila, Montazer, Seyed Hosein, Hosseininejad, Seyed Mohammad, Golikhatir, Iraj, Abedian Kenari, Saeid, Alaee, Abdulrassol, Bozorgi, Farzad. Aldolase C Profiling in Serum after Mild Traumatic Brain Injury: A Prospective Cohort Study. سامانه مدیریت نشریات علمی, 1400; 47(1): 33-39. doi: 10.30476/ijms.2021.87692.1831

Aldolase C Profiling in Serum after Mild Traumatic Brain Injury: A Prospective Cohort Study

Iranian Journal of Medical Sciences
مقاله 5، دوره 47، شماره 1، فروردین 2022، صفحه 33-39    اصل مقاله (388.26 K)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/ijms.2021.87692.1831
نویسندگان
Kaveh Haddadi1؛ Siavash Moradi2؛ Leila Asadian3؛ Seyed Hosein Montazer4؛ Seyed Mohammad Hosseininejad5؛ Iraj Golikhatir6؛ Saeid Abedian Kenari7؛ Abdulrassol Alaee8؛ Farzad Bozorgi* 4
1Department of Neurosurgery, School of Medicine, Orthopedic Research Center, Mazandaran University of Medical Sciences, Sari, Iran
2Education Development Center, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
3Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran
4Department of Emergency Medicine, School of Medicine, Orthopedic Research Center, Mazandaran University of Medical Sciences, Sari, Iran
5Department of Emergency Medicine, School of Medicine, Diabetes Research Center, Mazandaran University of Medical Sciences, Sari, Iran
6Department of Emergency Medicine, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
7Immunogenetics Research Center, Mazandaran University of Medical Sciences, Sari, Iran
8Department of Radiology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
چکیده
Background: After a traumatic brain injury (TBI), in addition to clinical indices, the serum level of neurological biomarkers may provide valuable diagnostic and prognostic information. The present study aimed to investigate the aldolase C (ALDOC) profile in serum for early diagnosis of brain damage in patients with mild TBI (mTBI) presented to the Emergency Department (ED).
Methods: A single-center prospective cohort study was carried out in 2018-2019 at Imam Khomeini Hospital affiliated with Mazandaran University of Medical Sciences, Sari, Iran. A total of 89 patients with mTBI were enrolled in the study. Blood samples were taken within three hours after head trauma to measure ALDOC serum levels. Brain CT scan was used as the gold standard. Statistical analysis was performed using the Kruskal Wallis, Mann-Whitney U, and Chi square tests. The receiver-operating characteristic (ROC) curve plot was used to determine the optimal cutoff point for ALDOC. The sensitivity and specificity of the determined cutoff point were calculated. P values less than 0.05 were considered statistically significant.
Results: Of the 89 patients, the CT scan findings showed a positive TBI in 30 (33.7%) of the patients and in 59 (66.3%) a negative TBI. The median ALDOC serum level in the patients with positive CT scan findings (8.35 ng/mL [IQR: 1.65]) was significantly higher than those with negative CT scan findings (5.3 ng/mL [IQR: 6.9]) (p <0.001). The optimal cutoff point for ALDOC serum level was 6.95 ng/mL, and the area under the curve was 99.6% (p <0.001). The sensitivity and specificity of the determined cutoff point were 100% and 98%, respectively.
Conclusion: The ALDOC serum level in patients with mTBI significantly correlates with the pathologic findings of the brain CT scan. This biomarker, with 100% sensitivity, is a suitable tool to detect brain structural abnormalities in mTBI patients.
کلیدواژه‌ها
Serum؛ Brain injuries؛ Traumatic؛ Biomarker
سایر فایل های مرتبط با مقاله
مراجع
  1. O’Neil ME, Carlson K, Storzbach D, Brenner L, Freeman M, Quinones A, et al. Complications of Mild Traumatic Brain Injury in Veterans and Military Personnel: A Systematic Review. Washington: VA Evidence-based Synthesis Program Reports; 2013. doi: 10.1017/S135561771300146X.
  2. Dewan MC, Rattani A, Gupta S, Baticulon RE, Hung YC, Punchak M, et al. Estimating the global incidence of traumatic brain injury. J Neurosurg. 2018;130:1304-14. doi: 10.3171/2017.10.JNS17352. PubMed PMID: 29701556.
  3. Rogers S, Trickey AW. Classification of traumatic brain injury severity using retrospective data. Journal of Nursing Education and Practice. 2017;7:23-9. doi: 10.5430/jnep.v7n11p23.
  4. Skandsen T, Nilsen TL, Einarsen C, Normann I, McDonagh D, Haberg AK, et al. Incidence of Mild Traumatic Brain Injury: A Prospective Hospital, Emergency Room and General Practitioner-Based Study. Front Neurol. 2019;10:638. doi: 10.3389/fneur.2019.00638. PubMed PMID: 31275229; PubMed Central PMCID: PMCPMC6591366.
  5. Paul AB, Oklu R, Saini S, Prabhakar AM. How Much Is That Head CT? Price Transparency and Variability in Radiology. J Am Coll Radiol. 2015;12:453-7. doi: 10.1016/j.jacr.2014.12.016. PubMed PMID: 25841864.
  6. Blennow K, Brody DL, Kochanek PM, Levin H, McKee A, Ribbers GM, et al. Traumatic brain injuries. Nat Rev Dis Primers. 2016;2:16084. doi: 10.1038/nrdp.2016.84. PubMed PMID: 27853132.
  7. Baugh CM, Stamm JM, Riley DO, Gavett BE, Shenton ME, Lin A, et al. Chronic traumatic encephalopathy: neurodegeneration following repetitive concussive and subconcussive brain trauma. Brain Imaging Behav. 2012;6:244-54. doi: 10.1007/s11682-012-9164-5. PubMed PMID: 22552850.
  8. Papa L, Brophy GM, Welch RD, Lewis LM, Braga CF, Tan CN, et al. Time Course and Diagnostic Accuracy of Glial and Neuronal Blood Biomarkers GFAP and UCH-L1 in a Large Cohort of Trauma Patients With and Without Mild Traumatic Brain Injury. JAMA Neurol. 2016;73:551-60. doi: 10.1001/jamaneurol.2016.0039. PubMed PMID: 27018834.
  9. Shan R, Szmydynger-Chodobska J, Warren OU, Mohammad F, Zink BJ, Chodobski A. A New Panel of Blood Biomarkers for the Diagnosis of Mild Traumatic Brain Injury/Concussion in Adults. J Neurotrauma. 2016;33:49-57. doi: 10.1089/neu.2014.3811. PubMed PMID: 25794137.
  10. Ichkova A, Badaut J. New biomarker stars for traumatic brain injury. J Cereb Blood Flow Metab. 2017;37:3276-7. doi: 10.1177/0271678X17724683. PubMed PMID: 28816088; PubMed Central PMCID: PMCPMC5624402.
  11. Thelin EP, Just D, Frostell A, Haggmark-Manberg A, Risling M, Svensson M, et al. Protein profiling in serum after traumatic brain injury in rats reveals potential injury markers. Behav Brain Res. 2018;340:71-80. doi: 10.1016/j.bbr.2016.08.058. PubMed PMID: 27591967.
  12. Bohmer AE, Oses JP, Schmidt AP, Peron CS, Krebs CL, Oppitz PP, et al. Neuron-specific enolase, S100B, and glial fibrillary acidic protein levels as outcome predictors in patients with severe traumatic brain injury. Neurosurgery. 2011;68:1624-30. doi: 10.1227/NEU.0b013e318214a81f. PubMed PMID: 21368691.
  13. Stein DM, Kufera JA, Lindell A, Murdock KR, Menaker J, Bochicchio GV, et al. Association of CSF biomarkers and secondary insults following severe traumatic brain injury. Neurocrit Care. 2011;14:200-7. doi: 10.1007/s12028-010-9496-1. PubMed PMID: 21210304.
  14. Buonora JE, Yarnell AM, Lazarus RC, Mousseau M, Latour LL, Rizoli SB, et al. Multivariate analysis of traumatic brain injury: development of an assessment score. Front Neurol. 2015;6:68. doi: 10.3389/fneur.2015.00068. PubMed PMID: 25870583; PubMed Central PMCID: PMCPMC4378282.
  15. Liu M, Zhang C, Liu W, Luo P, Zhang L, Wang Y, et al. A novel rat model of blast-induced traumatic brain injury simulating different damage degree: implications for morphological, neurological, and biomarker changes. Front Cell Neurosci. 2015;9:168. doi: 10.3389/fncel.2015.00168. PubMed PMID: 25983677; PubMed Central PMCID: PMCPMC4416450.
  16. Topolovec-Vranic J, Pollmann-Mudryj MA, Ouchterlony D, Klein D, Spence J, Romaschin A, et al. The value of serum biomarkers in prediction models of outcome after mild traumatic brain injury. J Trauma. 2011;71:S478-86. doi: 10.1097/TA.0b013e318232fa70. PubMed PMID: 22072007.
  17. Diaz-Arrastia R, Wang KK, Papa L, Sorani MD, Yue JK, Puccio AM, et al. Acute biomarkers of traumatic brain injury: relationship between plasma levels of ubiquitin C-terminal hydrolase-L1 and glial fibrillary acidic protein. J Neurotrauma. 2014;31:19-25. doi: 10.1089/neu.2013.3040. PubMed PMID: 23865516; PubMed Central PMCID: PMCPMC3880090.
  18. Puvenna V, Brennan C, Shaw G, Yang C, Marchi N, Bazarian JJ, et al. Significance of ubiquitin carboxy-terminal hydrolase L1 elevations in athletes after sub-concussive head hits. PLoS One. 2014;9:e96296. doi: 10.1371/journal.pone.0096296. PubMed PMID: 24806476; PubMed Central PMCID: PMCPMC4012998.
  19. Tate CM, Wang KK, Eonta S, Zhang Y, Carr W, Tortella FC, et al. Serum brain biomarker level, neurocognitive performance, and self-reported symptom changes in soldiers repeatedly exposed to low-level blast: a breacher pilot study. J Neurotrauma. 2013;30:1620-30. doi: 10.1089/neu.2012.2683. PubMed PMID: 23687938.
  20. Welch RD, Ayaz SI, Lewis LM, Unden J, Chen JY, Mika VH, et al. Ability of Serum Glial Fibrillary Acidic Protein, Ubiquitin C-Terminal Hydrolase-L1, and S100B To Differentiate Normal and Abnormal Head Computed Tomography Findings in Patients with Suspected Mild or Moderate Traumatic Brain Injury. J Neurotrauma. 2016;33:203-14. doi: 10.1089/neu.2015.4149. PubMed PMID: 26467555; PubMed Central PMCID: PMCPMC4722555.
  21. Barbosa RR, Jawa R, Watters JM, Knight JC, Kerwin AJ, Winston ES, et al. Evaluation and management of mild traumatic brain injury: an Eastern Association for the Surgery of Trauma practice management guideline. J Trauma Acute Care Surg. 2012;73:S307-14. doi: 10.1097/TA.0b013e3182701885. PubMed PMID: 23114486.
  22. Metting Z, Wilczak N, Rodiger LA, Schaaf JM, van der Naalt J. GFAP and S100B in the acute phase of mild traumatic brain injury. Neurology. 2012;78:1428-33. doi: 10.1212/WNL.0b013e318253d5c7. PubMed PMID: 22517109.
  23. Zongo D, Ribereau-Gayon R, Masson F, Laborey M, Contrand B, Salmi LR, et al. S100-B protein as a screening tool for the early assessment of minor head injury. Ann Emerg Med. 2012;59:209-18. doi: 10.1016/j.annemergmed.2011.07.027. PubMed PMID: 21944878.
  24. Papa L, Silvestri S, Brophy GM, Giordano P, Falk JL, Braga CF, et al. GFAP out-performs S100beta in detecting traumatic intracranial lesions on computed tomography in trauma patients with mild traumatic brain injury and those with extracranial lesions. J Neurotrauma. 2014;31:1815-22. doi: 10.1089/neu.2013.3245. PubMed PMID: 24903744; PubMed Central PMCID: PMCPMC4224051.
  25. Glushakova OY, Jeromin A, Martinez J, Johnson D, Denslow N, Streeter J, et al. Cerebrospinal fluid protein biomarker panel for assessment of neurotoxicity induced by kainic acid in rats. Toxicol Sci. 2012;130:158-67. doi: 10.1093/toxsci/kfs224. PubMed PMID: 22790971.
  26. Zoltewicz JS, Mondello S, Yang B, Newsom KJ, Kobeissy F, Yao C, et al. Biomarkers track damage after graded injury severity in a rat model of penetrating brain injury. J Neurotrauma. 2013;30:1161-9. doi: 10.1089/neu.2012.2762. PubMed PMID: 23409698.
  27. Kou Z, Gattu R, Kobeissy F, Welch RD, O’Neil BJ, Woodard JL, et al. Combining biochemical and imaging markers to improve diagnosis and characterization of mild traumatic brain injury in the acute setting: results from a pilot study. PLoS One. 2013;8:e80296. doi: 10.1371/journal.pone.0080296. PubMed PMID: 24260364; PubMed Central PMCID: PMCPMC3833898.
  28. Okonkwo DO, Yue JK, Puccio AM, Panczykowski DM, Inoue T, McMahon PJ, et al. GFAP-BDP as an acute diagnostic marker in traumatic brain injury: results from the prospective transforming research and clinical knowledge in traumatic brain injury study. J Neurotrauma. 2013;30:1490-7. doi: 10.1089/neu.2013.2883. PubMed PMID: 23489259; PubMed Central PMCID: PMCPMC3751263.
  29. Schiff L, Hadker N, Weiser S, Rausch C. A literature review of the feasibility of glial fibrillary acidic protein as a biomarker for stroke and traumatic brain injury. Mol Diagn Ther. 2012;16:79-92. doi: 10.2165/11631580-000000000-00000. PubMed PMID: 22497529.
  30. Zetterberg H, Smith DH, Blennow K. Biomarkers of mild traumatic brain injury in cerebrospinal fluid and blood. Nat Rev Neurol. 2013;9:201-10. doi: 10.1038/nrneurol.2013.9. PubMed PMID: 23399646; PubMed Central PMCID: PMCPMC4513656.
  31. Halford J, Shen S, Itamura K, Levine J, Chong AC, Czerwieniec G, et al. New astroglial injury-defined biomarkers for neurotrauma assessment. J Cereb Blood Flow Metab. 2017;37:3278-99. doi: 10.1177/0271678X17724681. PubMed PMID: 28816095; PubMed Central PMCID: PMCPMC5624401.
آمار
تعداد مشاهده مقاله: 4,653
تعداد دریافت فایل اصل مقاله: 2,439


سامانه مدیریت نشریات علمی. قدرت گرفته از سیناوب