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Moustafa, Ehab, Hassan, Elham, Mahmoud, Mohamed, Mahmoud, Amal, Ghaliony, Mohamed. (1401). Deranged Lipid Profiles and Hepatocellular Carcinoma: Clinical Significance and Association. سامانه مدیریت نشریات علمی, 13(2), 275-284. doi: 10.30476/mejc.2021.86476.1346
Ehab Fawzy Abdo Moustafa; Elham Ahmed Hassan; Mohamed Mustafa Mahmoud; Amal A. Mahmoud; Mohamed AA Ghaliony. "Deranged Lipid Profiles and Hepatocellular Carcinoma: Clinical Significance and Association". سامانه مدیریت نشریات علمی, 13, 2, 1401, 275-284. doi: 10.30476/mejc.2021.86476.1346
Moustafa, Ehab, Hassan, Elham, Mahmoud, Mohamed, Mahmoud, Amal, Ghaliony, Mohamed. (1401). 'Deranged Lipid Profiles and Hepatocellular Carcinoma: Clinical Significance and Association', سامانه مدیریت نشریات علمی, 13(2), pp. 275-284. doi: 10.30476/mejc.2021.86476.1346
Moustafa, Ehab, Hassan, Elham, Mahmoud, Mohamed, Mahmoud, Amal, Ghaliony, Mohamed. Deranged Lipid Profiles and Hepatocellular Carcinoma: Clinical Significance and Association. سامانه مدیریت نشریات علمی, 1401; 13(2): 275-284. doi: 10.30476/mejc.2021.86476.1346

Deranged Lipid Profiles and Hepatocellular Carcinoma: Clinical Significance and Association

Middle East Journal of Cancer
مقاله 8، دوره 13، شماره 2 - شماره پیاپی 50، تیر 2022، صفحه 275-284    اصل مقاله (724.86 K)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/mejc.2021.86476.1346
نویسندگان
Ehab Fawzy Abdo Moustafa1؛ Elham Ahmed Hassan* 1؛ Mohamed Mustafa Mahmoud2؛ Amal A. Mahmoud3؛ Mohamed AA Ghaliony1
1Department of Gastroenterology and Tropical Medicine, Faculty of Medicine, Assiut University, Assiut, Egypt
2Fever Hospital, Ministry of Health, Sohag, Egypt
3Department of Clinical Pathology, Faculty of Medicine, Assiut University, Assiut, Egypt
چکیده
Background: The increasing incidence of hepatocellular carcinoma (HCC) is a challenging health problem worldwide with poor prognosis and limited treatment options. The association between metabolic factors and HCC has been documented, however, there is a shortage of data about this association in our locality. Therefore, we aimed to determine the pattern of lipid profile in cirrhotic patients with HCC and investigate the association between dyslipidemia and HCC.
Method: In this case-control hospital-based study, serum lipid profile [total cholesterol, triglycerides, low-density lipoprotein (LDL), high-density lipoprotein (HDL), and very-low-density lipoprotein (VLDL)] was determined in 100 patients with cirrhosis and 100 patients with cirrhosis and HCC. Multivariate analysis of HCC risk factors was done.
Results: Metabolic syndrome, hypertriglyceridemia, hypercholesterolemia, high LDL, and combined dyslipidemia were significantly more frequent in HCC patients than non-HCC patients. Low HDL and dyslipidemia were significantly associated with the late HCC stages and LDL levels were significantly correlated with α- fetoprotein levels. There was a tendency towards increasing the values of the other lipid parameters in advanced stages. Metabolic syndrome and combined dyslipidemia were associated with HCC risk.
Conclusion: Deranged lipid profiles were common in HCC patients. Metabolic syndrome and combined dyslipidemia could be potential risk factors for HCC and may offer a useful strategy for risk stratification; thus, their control can reduce the HCC burden.
کلیدواژه‌ها
Dyslipidemias؛ Hepatocellular carcinoma (HCC)؛ Metabolic syndrome؛ Risk factors
اصل مقاله

How to cite this article:

Abdo Moustafa EF, Hassan EA, Mahmoud MM, Mahmoud AA, Ghaliony MAA. Deranged lipid profiles and hepatocellular carcinoma: clinical significance and association. Middle East J Cancer. 2022;13(2):275-84. doi: 10.30476/mejc.2021.86476.1346.

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