The Interrelationship between Liver Function Test and the Novel Coronavirus Disease 2019: A Systematic Review and Meta-Analysis | ||
| Iranian Journal of Medical Sciences | ||
| مقاله 2، دوره 46، شماره 4، مهر 2021، صفحه 237-255 اصل مقاله (4.88 M) | ||
| نوع مقاله: Review Article | ||
| شناسه دیجیتال (DOI): 10.30476/ijms.2021.87555.1793 | ||
| نویسندگان | ||
| Mohammad Zahedi1؛ Mohammad Yousefi2؛ Mahdi Abounoori3؛ Mohammad Malekan3؛ Fatemeh Tajik4؛ Keyvan Heydari5؛ Parham Mortazavi6؛ Sulmaz Ghahramani7؛ Monireh Ghazaeian* 8؛ Fateme Sheydaee2؛ Amirreza Nasirzadeh9؛ Reza Alizadeh-Navaei5 | ||
| 1Department of Laboratory Sciences, School of Allied Medical Science, Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran | ||
| 2Department of Medicine, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran | ||
| 3Student Research Committee, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran | ||
| 4Department of Medicine, School of Medicine, Azad University of Tehran, Tehran, Iran | ||
| 5Gastrointestinal Cancer Research Center, Mazandaran University of Medical Sciences, Sari, Iran | ||
| 6Student Research Committee, School of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran | ||
| 7Health Policy Research Center, Institute of Health, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| 8Department of Clinical Pharmacy, School of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran | ||
| 9Student of Basic Sciences in Nursing, Student Research Committee, Gonabad University of Medical Sciences, Gonabad, Iran | ||
| چکیده | ||
| Background: The outbreak of the coronavirus disease-2019 (COVID-19) has become a global public health challenge. Assessing the effect of COVID-19 on liver injury is of great importance. A systematic review and meta-analysis were conducted to establish the characteristics of liver function tests in COVID-19 patients. Methods: A systematic search of publications from December 2019 up to April 2020 in Web of Science, Scopus, and Medline (via PubMed) databases was performed. Both cross-sectional and case series studies reporting an association between liver injury and COVID-19 infection were included. The data were analyzed using the STATA software (version 11.0) and the random-effects model for I2>50% was used to pool the results. Results: In this meta-analysis, 42 articles comprising a total of 6,557 COVID-19 patients were studied. The prevalence of increase in alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels was 30% and 21% in non-severe patients and 38% and 48% in severe patients, respectively. Patients with severe COVID-19 infection were 4.22, 4.96, and 4.13 times more likely to have elevated AST, ALT, and lactate dehydrogenase (LDH) levels, respectively. Conclusion: Elevation in liver function tests was higher in patients with severe than non-severe COVID-19 infection. Given the widespread use of drugs that increases the risk of hepatotoxicity, healthcare providers should be aware of changes in liver enzymes in COVID-19 patients. The inclusion of other studies from outside China could confirm the pattern of elevation in liver function tests in COVID-19 patients across the globe. Preprint of this article is available on medRxiv, https://www.medrxiv.org/content/10.1101/2020.05.20.20108357v1 | ||
| کلیدواژهها | ||
| COVID-19؛ SARS-CoV-2؛ Liver function tests | ||
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